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01.10.2012 | Original Article

Effects of a proton pump inhibitor on the physiological accumulation of fluoro-2-deoxy-d-glucose (FDG) in FDG-positron emission tomography

verfasst von: Yasushi Domeki, Erena Yamazaki, Akira Matsuura, Kazuhiro Kitajima, Koji Murakami, Hiroyuki Kato

Erschienen in: Surgery Today | Ausgabe 10/2012

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Abstract

Purposes

The physiological accumulation of fluoro-2-deoxy-d-glucose (FDG) is common in medical examinations of the digestive tract conducted using FDG-positron emission tomography (PET). The aim of this study was to determine the effects of a proton pump inhibitor (PPI) on the physiological FDG accumulation in the digestive tract.

Methods

A total of 130 patients examined from July 2007 to October 2008 were included in the final analysis. A PPI was administered orally prior to FDG-PET in 65 patients. The remaining 65 patients underwent FDG-PET without administration of the PPI. The assessments used visual and quantitative evaluations.

Results

Visual evaluation showed that physiological FDG accumulation in the stomach was significantly reduced (p = 0.037) in the PPI group compared with the control group. The quantitative evaluation also revealed a significant reduction in the maximum standardized uptake values (SUV_max) in the stomach in the PPI group compared with the control group (p < 0.0001). Physiological FDG accumulation in the colon showed a decreasing trend on visual evaluation in the PPI group compared with the control group, and the quantitative evaluation found a significant reduction in the physiological FDG accumulation in the colon in the PPI group (p = 0.045).

Conclusions

The oral administration of a PPI was effective for reducing the physiological accumulation of the FDG in the alimentary tract. However, based on the error associated with SUV_max measurement, a quantitative evaluation should therefore be combined with the visual evaluation.

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Titel: Effects of a proton pump inhibitor on the physiological accumulation of fluoro-2-deoxy-d-glucose (FDG) in FDG-positron emission tomography
verfasst von: Yasushi Domeki
Erena Yamazaki
Akira Matsuura
Kazuhiro Kitajima
Koji Murakami
Hiroyuki Kato
Publikationsdatum: 01.10.2012
Verlag: Springer Japan
Erschienen in: Surgery Today / Ausgabe 10/2012
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-012-0265-y

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Abstract

Purposes

Methods

Results

Conclusions

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