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Erschienen in:

01.03.2015 | Translational Neurosciences - Original Article

Effects of a short-term reduction in brain serotonin synthesis on the availability of the soluble leptin receptor in healthy women

verfasst von: F. D. Zepf, V. L. S. Dingerkus, K. Helmbold, S. Bubenzer-Busch, C. S. Biskup, B. Herpertz-Dahlmann, M. Schaab, J. Kratzsch, A. Eisert, L. Rink, U. Hagenah, T. J. Gaber

Erschienen in: Journal of Neural Transmission | Ausgabe 3/2015

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Abstract

Serotonin (5-HT) and the hormone leptin have been linked to the underlying neurobiology of appetite regulation with evidence coming from animal and cellular research, but direct evidence linking these two pathways in humans is lacking. We examined the effects of reduced brain 5-HT synthesis due to acute tryptophan depletion (ATD) on levels of soluble leptin receptor (sOb-R), the main high-affinity leptin binding protein, in healthy adults using an exploratory approach. Women, but not men, showed reduced sOb-R concentrations after ATD administration. With females showing reduced baseline levels of central 5-HT synthesis compared to males diminished brain 5-HT synthesis affected the leptin axis through the sOb-R in females, thereby potentially influencing their vulnerability to dysfunctional appetite regulation and co-morbid mood symptoms.

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Titel: Effects of a short-term reduction in brain serotonin synthesis on the availability of the soluble leptin receptor in healthy women
verfasst von: F. D. Zepf
V. L. S. Dingerkus
K. Helmbold
S. Bubenzer-Busch
C. S. Biskup
B. Herpertz-Dahlmann
M. Schaab
J. Kratzsch
A. Eisert
L. Rink
U. Hagenah
T. J. Gaber
Publikationsdatum: 01.03.2015
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 3/2015
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-014-1292-1

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