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07.08.2019 | Original Article

Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial

verfasst von: Seyed Mostafa Nachvak, Beitollah Alipour, Aida Malek Mahdavi, Mir Amir Aghdashi, Hadi Abdollahzad, Yahya Pasdar, Mehnoosh Samadi, Roghayeh Mostafai

Erschienen in: Clinical Rheumatology | Ausgabe 12/2019

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Abstract

Objectives

This study aimed to assess the effect of CoQ10 supplementation on serum matrix metalloproteinases (MMPs) and clinical parameters in rheumatoid arthritis (RA) patients.

Method

In this randomized, double-blind, placebo-controlled trial, 54 RA patients who fulfilled the eligibility criteria (18–56 years, diagnosed at least 6 months ago, with DAS-28 > 3.2) were randomly assigned into two groups to receive 100 mg/day CoQ10 (n = 27) or placebo (n = 27) for 2 months. Serum MMP-1 and MMP-3 levels and clinical status using disease activity score in 28 joints (DAS-28) were assessed before and after supplementation. Data were analyzed using χ2, independent sample t test, paired t test, Wilcoxon, Mann-Whitney, and analysis of covariance.

Results

A significant reduction was observed in both CoQ10 and placebo groups in the medians of serum MMP-1 (0.2 to 0.16, P < 0.001), (0.18 to 0.15, P = 0.001); swollen joint count (2 to 0, P < 0.001), (2 to 0, P = 0.009); and the means of DAS-28 (5.01 ± 1.21 to 2.34 ± 0.68, P < 0.001), (4.88 ± 0.96 to 4.04 ± 1.36, P = 0.009) respectively. Serum MMP-3 level increased significantly in placebo group (2.26 to 2.57, P = 0.020), and the MMP-3 changes between groups were significant (P = 0.027). Furthermore, significant reductions were only observed in ESR, pain score, and tender joint count in CoQ10 group compared with baseline (P = 0.001, P < 0.001, and P < 0.001, respectively). Significant differences were observed between two groups in DAS-28, pain score, and swollen and tender joint count after the intervention (P < 0.001, P < 0.001, and P = 0.012 and P < 0.001, respectively).

Conclusions

It seems that CoQ10 may provide a new complementary approach for RA patients.

Key Points

• CoQ10 supplementation in RA patients attenuated serum MMP-3 level.

• CoQ10 supplementation in RA patients improved clinical outcomes and ameliorated disease severity.

• CoQ10 may provide a new complementary approach for patients with RA.

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Titel: Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial
verfasst von: Seyed Mostafa Nachvak
Beitollah Alipour
Aida Malek Mahdavi
Mir Amir Aghdashi
Hadi Abdollahzad
Yahya Pasdar
Mehnoosh Samadi
Roghayeh Mostafai
Publikationsdatum: 07.08.2019
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 12/2019
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-019-04723-x

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