Skip to main content
Erschienen in: Sports Medicine 1/2020

17.09.2019 | Review Article

Effects of Dietary Supplements on Adaptations to Endurance Training

verfasst von: Jeffrey A. Rothschild, David J. Bishop

Erschienen in: Sports Medicine | Ausgabe 1/2020

Einloggen, um Zugang zu erhalten

Abstract

Endurance training leads to a variety of adaptations at the cellular and systemic levels that serve to minimise disruptions in whole-body homeostasis caused by exercise. These adaptations are differentially affected by training volume, training intensity, and training status, as well as by nutritional choices that can enhance or impair the response to training. A variety of supplements have been studied in the context of acute performance enhancement, but the effects of continued supplementation concurrent to endurance training programs are less well characterised. For example, supplements such as sodium bicarbonate and beta-alanine can improve endurance performance and possibly training adaptations during endurance training by affecting buffering capacity and/or allowing an increased training intensity, while antioxidants such as vitamin C and vitamin E may impair training adaptations by blunting cellular signalling but appear to have little effect on performance outcomes. Additionally, limited data suggest the potential for dietary nitrate (in the form of beetroot juice), creatine, and possibly caffeine, to further enhance endurance training adaptation. Therefore, the objective of this review is to examine the impact of dietary supplements on metabolic and physiological adaptations to endurance training.
Literatur
1.
Zurück zum Zitat Hawley JA. Adaptations of skeletal muscle to prolonged, intense endurance training. Clin Exp Pharmacol Physiol. 2002;29(3):218–22.PubMed Hawley JA. Adaptations of skeletal muscle to prolonged, intense endurance training. Clin Exp Pharmacol Physiol. 2002;29(3):218–22.PubMed
3.
Zurück zum Zitat Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013;17(2):162–84.PubMed Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013;17(2):162–84.PubMed
4.
Zurück zum Zitat Perry CG, Lally J, Holloway GP, Heigenhauser GJ, Bonen A, Spriet LL. Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol. 2010;588(23):4795–810.PubMedPubMedCentral Perry CG, Lally J, Holloway GP, Heigenhauser GJ, Bonen A, Spriet LL. Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol. 2010;588(23):4795–810.PubMedPubMedCentral
5.
Zurück zum Zitat Seiler S. What is best practice for training intensity and duration distribution in endurance athletes? Int J Sports Physiol Perform. 2010;5(3):276–91.PubMed Seiler S. What is best practice for training intensity and duration distribution in endurance athletes? Int J Sports Physiol Perform. 2010;5(3):276–91.PubMed
6.
Zurück zum Zitat Rothschild J, Earnest CP. Dietary manipulations concurrent to endurance training. J Funct Morphol Kinesiol. 2018;3(3):41. Rothschild J, Earnest CP. Dietary manipulations concurrent to endurance training. J Funct Morphol Kinesiol. 2018;3(3):41.
7.
Zurück zum Zitat Knapik JJ, Steelman RA, Hoedebecke SS, Austin KG, Farina EK, Lieberman HR. Prevalence of dietary supplement use by athletes: systematic review and meta-analysis. Sports Med. 2016;46(1):103–23.PubMed Knapik JJ, Steelman RA, Hoedebecke SS, Austin KG, Farina EK, Lieberman HR. Prevalence of dietary supplement use by athletes: systematic review and meta-analysis. Sports Med. 2016;46(1):103–23.PubMed
10.
Zurück zum Zitat Domínguez R, Cuenca E, Maté-Muñoz JL, García-Fernández P, Serra-Paya N, Estevan MCL, et al. Effects of beetroot juice supplementation on cardiorespiratory endurance in athletes. A systematic review. Nutrients. 2017;9(1):43.PubMedCentral Domínguez R, Cuenca E, Maté-Muñoz JL, García-Fernández P, Serra-Paya N, Estevan MCL, et al. Effects of beetroot juice supplementation on cardiorespiratory endurance in athletes. A systematic review. Nutrients. 2017;9(1):43.PubMedCentral
16.
Zurück zum Zitat McNaughton LR, Gough L, Deb S, Bentley D, Sparks SA. Recent developments in the use of sodium bicarbonate as an ergogenic aid. Curr Sports Med Rep. 2016;15(4):233–44.PubMed McNaughton LR, Gough L, Deb S, Bentley D, Sparks SA. Recent developments in the use of sodium bicarbonate as an ergogenic aid. Curr Sports Med Rep. 2016;15(4):233–44.PubMed
17.
Zurück zum Zitat Hayashi T, Shigetomi T, Ueda M, Kaneda T, Matsumoto T, Tokuno H, et al. Effects of ammonium chloride on membrane currents of acinar cells dispersed from the rat parotid gland. Pflug Arch. 1992;420(3–4):297–301. Hayashi T, Shigetomi T, Ueda M, Kaneda T, Matsumoto T, Tokuno H, et al. Effects of ammonium chloride on membrane currents of acinar cells dispersed from the rat parotid gland. Pflug Arch. 1992;420(3–4):297–301.
25.
Zurück zum Zitat Preobrazenski N, Bonafiglia JT, Nelms MW, Lu S, Robins L, LeBlanc C, et al. Does blood lactate predict the chronic adaptive response to training: a comparison of traditional and talk test prescription methods. Appl Physiol Nutr Metab. 2018;44(2):179–86.PubMed Preobrazenski N, Bonafiglia JT, Nelms MW, Lu S, Robins L, LeBlanc C, et al. Does blood lactate predict the chronic adaptive response to training: a comparison of traditional and talk test prescription methods. Appl Physiol Nutr Metab. 2018;44(2):179–86.PubMed
27.
Zurück zum Zitat Percival ME, Martin BJ, Gillen JB, Skelly LE, MacInnis MJ, Green AE, et al. Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle. J Appl Physiol. 2015;119(11):1303–12.PubMedPubMedCentral Percival ME, Martin BJ, Gillen JB, Skelly LE, MacInnis MJ, Green AE, et al. Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle. J Appl Physiol. 2015;119(11):1303–12.PubMedPubMedCentral
28.
Zurück zum Zitat Cochran AJ, Percival ME, Tricarico S, Little JP, Cermak N, Gillen JB, et al. Intermittent and continuous high-intensity exercise training induce similar acute but different chronic muscle adaptations. Exp Physiol. 2014;99(5):782–91.PubMed Cochran AJ, Percival ME, Tricarico S, Little JP, Cermak N, Gillen JB, et al. Intermittent and continuous high-intensity exercise training induce similar acute but different chronic muscle adaptations. Exp Physiol. 2014;99(5):782–91.PubMed
29.
Zurück zum Zitat Burke LM, Pyne DB. Bicarbonate loading to enhance training and competitive performance. Int J Sports Physiol Perform. 2007;2(1):93–7.PubMed Burke LM, Pyne DB. Bicarbonate loading to enhance training and competitive performance. Int J Sports Physiol Perform. 2007;2(1):93–7.PubMed
33.
Zurück zum Zitat Edge J, Bishop D, Goodman C. Effects of chronic NaHCO3 ingestion during interval training on changes to muscle buffer capacity, metabolism, and short-term endurance performance. J Appl Physiol. 2006;101(3):918–25.PubMed Edge J, Bishop D, Goodman C. Effects of chronic NaHCO3 ingestion during interval training on changes to muscle buffer capacity, metabolism, and short-term endurance performance. J Appl Physiol. 2006;101(3):918–25.PubMed
35.
Zurück zum Zitat Hawke E, Hammarström D, Sahlin K, Tonkonogi M. Does six-weeks of high-intensity cycle training with induced changes in acid-base balance lead to mitochondrial adaptations? J Sci Cycl. 2014;3(2):82. Hawke E, Hammarström D, Sahlin K, Tonkonogi M. Does six-weeks of high-intensity cycle training with induced changes in acid-base balance lead to mitochondrial adaptations? J Sci Cycl. 2014;3(2):82.
36.
Zurück zum Zitat Driller MW, Gregory JR, Williams AD, Fell JW. The effects of chronic sodium bicarbonate ingestion and interval training in highly trained rowers. Int J Sport Nutr Exerc Metab. 2013;23(1):40–7.PubMed Driller MW, Gregory JR, Williams AD, Fell JW. The effects of chronic sodium bicarbonate ingestion and interval training in highly trained rowers. Int J Sport Nutr Exerc Metab. 2013;23(1):40–7.PubMed
37.
Zurück zum Zitat Bishop DJ, Thomas C, Moore-Morris T, Tonkonogi M, Sahlin K, Mercier J. Sodium bicarbonate ingestion prior to training improves mitochondrial adaptations in rats. Am J Physiol Endocrinol Metab. 2010;299(2):E225–33.PubMed Bishop DJ, Thomas C, Moore-Morris T, Tonkonogi M, Sahlin K, Mercier J. Sodium bicarbonate ingestion prior to training improves mitochondrial adaptations in rats. Am J Physiol Endocrinol Metab. 2010;299(2):E225–33.PubMed
38.
Zurück zum Zitat Thomas C, Bishop D, Moore-Morris T, Mercier J. Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis. Am J Physiol Endocrinol Metab. 2007;293(4):E916–22.PubMed Thomas C, Bishop D, Moore-Morris T, Mercier J. Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis. Am J Physiol Endocrinol Metab. 2007;293(4):E916–22.PubMed
39.
Zurück zum Zitat Lundby C, Montero D, Joyner M. Biology of VO2max: looking under the physiology lamp. J Acta Physiologica. 2017;220(2):218–28. Lundby C, Montero D, Joyner M. Biology of VO2max: looking under the physiology lamp. J Acta Physiologica. 2017;220(2):218–28.
40.
Zurück zum Zitat Stellingwerff T, Anwander H, Egger A, Buehler T, Kreis R, Decombaz J, et al. Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids. 2012;42(6):2461–72.PubMed Stellingwerff T, Anwander H, Egger A, Buehler T, Kreis R, Decombaz J, et al. Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids. 2012;42(6):2461–72.PubMed
43.
Zurück zum Zitat Baguet A, Koppo K, Pottier A, Derave W. β-Alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise. Eur J Appl Physiol. 2010;108(3):495–503.PubMed Baguet A, Koppo K, Pottier A, Derave W. β-Alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise. Eur J Appl Physiol. 2010;108(3):495–503.PubMed
45.
Zurück zum Zitat Glenn J, Gray M, Stewart R, Moyen N, Kavouras S, DiBrezzo R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids. 2015;47(12):2593–600.PubMed Glenn J, Gray M, Stewart R, Moyen N, Kavouras S, DiBrezzo R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids. 2015;47(12):2593–600.PubMed
46.
Zurück zum Zitat Begum G, Cunliffe A, Leveritt M. Physiological role of carnosine in contracting muscle. Int J Sport Nutr Exerc Metab. 2005;15(5):493–514.PubMed Begum G, Cunliffe A, Leveritt M. Physiological role of carnosine in contracting muscle. Int J Sport Nutr Exerc Metab. 2005;15(5):493–514.PubMed
49.
Zurück zum Zitat Dutka TL, Lamboley CR, McKenna MJ, Murphy RM, Lamb GD. Effects of carnosine on contractile apparatus Ca2+ sensitivity and sarcoplasmic reticulum Ca2+ release in human skeletal muscle fibers. J Appl Physiol. 2011;112(5):728–36.PubMed Dutka TL, Lamboley CR, McKenna MJ, Murphy RM, Lamb GD. Effects of carnosine on contractile apparatus Ca2+ sensitivity and sarcoplasmic reticulum Ca2+ release in human skeletal muscle fibers. J Appl Physiol. 2011;112(5):728–36.PubMed
50.
Zurück zum Zitat Hannah R, Stannard RL, Minshull C, Artioli GG, Harris RC, Sale C. β-Alanine supplementation enhances human skeletal muscle relaxation speed but not force production capacity. J Appl Physiol. 2014;118(5):604–12.PubMed Hannah R, Stannard RL, Minshull C, Artioli GG, Harris RC, Sale C. β-Alanine supplementation enhances human skeletal muscle relaxation speed but not force production capacity. J Appl Physiol. 2014;118(5):604–12.PubMed
52.
Zurück zum Zitat Schnuck JK, Sunderland KL, Kuennen MR, Vaughan RA. Characterization of the metabolic effect of β-alanine on markers of oxidative metabolism and mitochondrial biogenesis in skeletal muscle. J Exerc Nutr Biochem. 2016;20(2):34. Schnuck JK, Sunderland KL, Kuennen MR, Vaughan RA. Characterization of the metabolic effect of β-alanine on markers of oxidative metabolism and mitochondrial biogenesis in skeletal muscle. J Exerc Nutr Biochem. 2016;20(2):34.
54.
Zurück zum Zitat Walter AA, Smith AE, Kendall KL, Stout JR, Cramer JT. Six weeks of high-intensity interval training with and without β-alanine supplementation for improving cardiovascular fitness in women. J Strength Cond Res. 2010;24(5):1199–207.PubMed Walter AA, Smith AE, Kendall KL, Stout JR, Cramer JT. Six weeks of high-intensity interval training with and without β-alanine supplementation for improving cardiovascular fitness in women. J Strength Cond Res. 2010;24(5):1199–207.PubMed
55.
Zurück zum Zitat Cochran AJ, Percival ME, Thompson S, Gillen JB, MacInnis MJ, Potter MA, et al. β-Alanine supplementation does not augment the skeletal muscle adaptive response to 6 weeks of sprint interval training. Int J Sport Nutr Exerc Metab. 2015;25(6):541–9.PubMed Cochran AJ, Percival ME, Thompson S, Gillen JB, MacInnis MJ, Potter MA, et al. β-Alanine supplementation does not augment the skeletal muscle adaptive response to 6 weeks of sprint interval training. Int J Sport Nutr Exerc Metab. 2015;25(6):541–9.PubMed
59.
Zurück zum Zitat Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab. 2013;23(6):562–70.PubMed Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab. 2013;23(6):562–70.PubMed
60.
Zurück zum Zitat Bellinger PM, Minahan CL. Metabolic consequences of β-alanine supplementation during exhaustive supramaximal cycling and 4000-m time-trial performance. Appl Physiol Nutr Metab. 2016;41(8):864–71.PubMed Bellinger PM, Minahan CL. Metabolic consequences of β-alanine supplementation during exhaustive supramaximal cycling and 4000-m time-trial performance. Appl Physiol Nutr Metab. 2016;41(8):864–71.PubMed
62.
Zurück zum Zitat Hobson RM, Saunders B, Ball G, Harris R, Sale C. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012;43(1):25–37.PubMedPubMedCentral Hobson RM, Saunders B, Ball G, Harris R, Sale C. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012;43(1):25–37.PubMedPubMedCentral
69.
Zurück zum Zitat Lundberg JO, Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med. 2004;37(3):395–400.PubMed Lundberg JO, Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med. 2004;37(3):395–400.PubMed
70.
Zurück zum Zitat Rimer EG, Peterson LR, Coggan AR, Martin JC. Acute dietary nitrate supplementation increases maximal cycling power in athletes. Int J Sports Physiol Perform. 2016;11(6):715.PubMedPubMedCentral Rimer EG, Peterson LR, Coggan AR, Martin JC. Acute dietary nitrate supplementation increases maximal cycling power in athletes. Int J Sports Physiol Perform. 2016;11(6):715.PubMedPubMedCentral
78.
Zurück zum Zitat Whitfield J, Ludzki A, Heigenhauser GJ, Senden JM, Verdijk LB, van Loon LJ, et al. Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle. J Physiol. 2016;594(2):421–35. https://doi.org/10.1113/JP270844.CrossRefPubMed Whitfield J, Ludzki A, Heigenhauser GJ, Senden JM, Verdijk LB, van Loon LJ, et al. Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle. J Physiol. 2016;594(2):421–35. https://​doi.​org/​10.​1113/​JP270844.CrossRefPubMed
79.
Zurück zum Zitat Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, et al. Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor γ coactivator-1α mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol. 2010;588(10):1779–90.PubMedPubMedCentral Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, et al. Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor γ coactivator-1α mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol. 2010;588(10):1779–90.PubMedPubMedCentral
81.
Zurück zum Zitat Croitoru MD, Fülöp I, Fogarasi E, Muntean D-L. Is nitrate a good biomarker of the nitric oxide status?/Este ionul nitrat un bun biomarker al producţiei endogene de monoxid de azot? Rev Rom Med Lab. 2015;23(1):127–35. Croitoru MD, Fülöp I, Fogarasi E, Muntean D-L. Is nitrate a good biomarker of the nitric oxide status?/Este ionul nitrat un bun biomarker al producţiei endogene de monoxid de azot? Rev Rom Med Lab. 2015;23(1):127–35.
83.
Zurück zum Zitat Puype J, Ramaekers M, Van Thienen R, Deldicque L, Hespel P. No effect of dietary nitrate supplementation on endurance training in hypoxia. Scand J Med Sci Sports. 2015;25(2):234–41.PubMed Puype J, Ramaekers M, Van Thienen R, Deldicque L, Hespel P. No effect of dietary nitrate supplementation on endurance training in hypoxia. Scand J Med Sci Sports. 2015;25(2):234–41.PubMed
85.
Zurück zum Zitat Thompson C, Vanhatalo A, Kadach S, Wylie LJ, Fulford J, Ferguson SK, et al. Discrete physiological effects of beetroot juice and potassium nitrate supplementation following 4-wk sprint interval training. J Appl Physiol. 2018;124(6):1519–28.PubMed Thompson C, Vanhatalo A, Kadach S, Wylie LJ, Fulford J, Ferguson SK, et al. Discrete physiological effects of beetroot juice and potassium nitrate supplementation following 4-wk sprint interval training. J Appl Physiol. 2018;124(6):1519–28.PubMed
89.
Zurück zum Zitat Wootton-Beard PC, Ryan L. Combined use of multiple methodologies for the measurement of total antioxidant capacity in UK commercially available vegetable juices. Plant Foods Hum Nutr. 2012;67(2):142–7.PubMed Wootton-Beard PC, Ryan L. Combined use of multiple methodologies for the measurement of total antioxidant capacity in UK commercially available vegetable juices. Plant Foods Hum Nutr. 2012;67(2):142–7.PubMed
91.
Zurück zum Zitat Bergh U, Thorstensson A, Sjodin B, Hulten B, Piehl K, Karlsson J. Maximal oxygen uptake and muscle fiber types in trained and untrained humans. Med Sci Sports. 1978;10(3):151–4.PubMed Bergh U, Thorstensson A, Sjodin B, Hulten B, Piehl K, Karlsson J. Maximal oxygen uptake and muscle fiber types in trained and untrained humans. Med Sci Sports. 1978;10(3):151–4.PubMed
92.
Zurück zum Zitat Foster C, Costill DL, Daniels JT, Fink WJ. Skeletal muscle enzyme activity, fiber composition and VO2max in relation to distance running performance. Eur J Appl Physiol Occup Physiol. 1978;39(2):73–80.PubMed Foster C, Costill DL, Daniels JT, Fink WJ. Skeletal muscle enzyme activity, fiber composition and VO2max in relation to distance running performance. Eur J Appl Physiol Occup Physiol. 1978;39(2):73–80.PubMed
94.
Zurück zum Zitat Roberts LD, Ashmore T, McNally BD, Murfitt SA, Fernandez BO, Feelisch M, et al. Inorganic nitrate mimics exercise-stimulated muscular fiber-type switching and myokine and γ-aminobutyric acid release. Diabetes. 2017;66(3):674–88.PubMed Roberts LD, Ashmore T, McNally BD, Murfitt SA, Fernandez BO, Feelisch M, et al. Inorganic nitrate mimics exercise-stimulated muscular fiber-type switching and myokine and γ-aminobutyric acid release. Diabetes. 2017;66(3):674–88.PubMed
96.
Zurück zum Zitat Piknova B, Park JW, Swanson KM, Dey S, Noguchi CT, Schechter AN. Skeletal muscle as an endogenous nitrate reservoir. Nitric Oxide. 2015;47:10–6.PubMedPubMedCentral Piknova B, Park JW, Swanson KM, Dey S, Noguchi CT, Schechter AN. Skeletal muscle as an endogenous nitrate reservoir. Nitric Oxide. 2015;47:10–6.PubMedPubMedCentral
101.
Zurück zum Zitat Moopanar TR, Allen DG. Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37 C. J Physiol. 2005;564(1):189–99.PubMedPubMedCentral Moopanar TR, Allen DG. Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37 C. J Physiol. 2005;564(1):189–99.PubMedPubMedCentral
102.
Zurück zum Zitat Gomez-Cabrera M-C, Domenech E, Viña J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med. 2008;44(2):126–31.PubMed Gomez-Cabrera M-C, Domenech E, Viña J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med. 2008;44(2):126–31.PubMed
104.
Zurück zum Zitat Irrcher I, Ljubicic V, Hood DA. Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells. Am J Physiol Cell Physiol. 2009;296(1):C116–23.PubMed Irrcher I, Ljubicic V, Hood DA. Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells. Am J Physiol Cell Physiol. 2009;296(1):C116–23.PubMed
105.
Zurück zum Zitat Merry TL, Ristow M. Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? J Physiol. 2016;594(18):5135–47.PubMedPubMedCentral Merry TL, Ristow M. Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? J Physiol. 2016;594(18):5135–47.PubMedPubMedCentral
108.
Zurück zum Zitat Gómez-Cabrera M-C, Pallardó FV, Sastre J, Viña J, García-del-Moral L. Allopurinol and markers of muscle damage among participants in the Tour de France. JAMA. 2003;289(19):2503–4.PubMed Gómez-Cabrera M-C, Pallardó FV, Sastre J, Viña J, García-del-Moral L. Allopurinol and markers of muscle damage among participants in the Tour de France. JAMA. 2003;289(19):2503–4.PubMed
111.
Zurück zum Zitat Gomez-Cabrera MC, Salvador-Pascual A, Cabo H, Ferrando B, Viña J. Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training? Free Radic Biol Med. 2015;86:37–46.PubMed Gomez-Cabrera MC, Salvador-Pascual A, Cabo H, Ferrando B, Viña J. Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training? Free Radic Biol Med. 2015;86:37–46.PubMed
113.
Zurück zum Zitat Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee J-H, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003;22(1):18–35.PubMed Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee J-H, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003;22(1):18–35.PubMed
114.
Zurück zum Zitat Sharman IM, Down MG, Sen RN. The effects of vitamin E and training on physiological function and athletic performance in adolescent swimmers. Br J Nutr. 1971;26(2):265–76.PubMed Sharman IM, Down MG, Sen RN. The effects of vitamin E and training on physiological function and athletic performance in adolescent swimmers. Br J Nutr. 1971;26(2):265–76.PubMed
116.
Zurück zum Zitat Rokitzki L, Logemann E, Huber G, Keck E, Keul J. alpha-Tocopherol supplementation in racing cyclists during extreme endurance training. Int J Sport Nutr. 1994;4(3):253–64.PubMed Rokitzki L, Logemann E, Huber G, Keck E, Keul J. alpha-Tocopherol supplementation in racing cyclists during extreme endurance training. Int J Sport Nutr. 1994;4(3):253–64.PubMed
117.
Zurück zum Zitat Oostenbrug G, Mensink R, Hardeman M, De Vries T, Brouns F, Hornstra G. Exercise performance, red blood cell deformability, and lipid peroxidation: effects of fish oil and vitamin E. J Appl Physiol. 1997;83(3):746–52.PubMed Oostenbrug G, Mensink R, Hardeman M, De Vries T, Brouns F, Hornstra G. Exercise performance, red blood cell deformability, and lipid peroxidation: effects of fish oil and vitamin E. J Appl Physiol. 1997;83(3):746–52.PubMed
120.
Zurück zum Zitat Roberts LA, Beattie K, Close GL, Morton JP. Vitamin C consumption does not impair training-induced improvements in exercise performance. Int J Sports Physiol Perform. 2011;6(1):58–69.PubMed Roberts LA, Beattie K, Close GL, Morton JP. Vitamin C consumption does not impair training-induced improvements in exercise performance. Int J Sports Physiol Perform. 2011;6(1):58–69.PubMed
121.
Zurück zum Zitat Bryant RJ, Ryder J, Martino P, Kim J, Craig BW. Effects of vitamin E and C supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. J Strength Cond Res. 2003;17(4):792–800.PubMed Bryant RJ, Ryder J, Martino P, Kim J, Craig BW. Effects of vitamin E and C supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. J Strength Cond Res. 2003;17(4):792–800.PubMed
122.
Zurück zum Zitat Paulsen G, Cumming KT, Holden G, Hallén J, Rønnestad BR, Sveen O, et al. Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial. J Physiol. 2014;592(8):1887–901.PubMedPubMedCentral Paulsen G, Cumming KT, Holden G, Hallén J, Rønnestad BR, Sveen O, et al. Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial. J Physiol. 2014;592(8):1887–901.PubMedPubMedCentral
123.
Zurück zum Zitat Yfanti C, Akerström T, Nielsen S, Nielsen AR, Mounier R, Mortensen OH, et al. Antioxidant supplementation does not alter endurance training adaptation. Med Sci Sports Exerc. 2010;42(7):1388–95.PubMed Yfanti C, Akerström T, Nielsen S, Nielsen AR, Mounier R, Mortensen OH, et al. Antioxidant supplementation does not alter endurance training adaptation. Med Sci Sports Exerc. 2010;42(7):1388–95.PubMed
125.
Zurück zum Zitat Morrison D, Hughes J, Della Gatta PA, Mason S, Lamon S, Russell AP, et al. Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans. Free Radic Biol Med. 2015;89:852–62.PubMed Morrison D, Hughes J, Della Gatta PA, Mason S, Lamon S, Russell AP, et al. Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans. Free Radic Biol Med. 2015;89:852–62.PubMed
126.
132.
Zurück zum Zitat Kim JC, Park GD, Kim SH. Inhibition of oxidative stress by antioxidant supplementation does not limit muscle mitochondrial biogenesis or endurance capacity in rats. J Nutr Sci Vitaminol (Tokyo). 2017;63(5):277–83.PubMed Kim JC, Park GD, Kim SH. Inhibition of oxidative stress by antioxidant supplementation does not limit muscle mitochondrial biogenesis or endurance capacity in rats. J Nutr Sci Vitaminol (Tokyo). 2017;63(5):277–83.PubMed
134.
Zurück zum Zitat Asha Devi S, Prathima S, Subramanyam MV. Dietary vitamin E and physical exercise: I. Altered endurance capacity and plasma lipid profile in ageing rats. Exp Gerontol. 2003;38(3):285–90.PubMed Asha Devi S, Prathima S, Subramanyam MV. Dietary vitamin E and physical exercise: I. Altered endurance capacity and plasma lipid profile in ageing rats. Exp Gerontol. 2003;38(3):285–90.PubMed
135.
Zurück zum Zitat Abbott MJ, Edelman AM, Turcotte LP. CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2009;297(6):R1724–32.PubMed Abbott MJ, Edelman AM, Turcotte LP. CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2009;297(6):R1724–32.PubMed
137.
Zurück zum Zitat Nieman DC, Henson DA, McAnulty SR, McAnulty LS, Morrow JD, Ahmed A, et al. Vitamin E and immunity after the Kona Triathlon World Championship. Med Sci Sports Exerc. 2004;36(8):1328–35.PubMed Nieman DC, Henson DA, McAnulty SR, McAnulty LS, Morrow JD, Ahmed A, et al. Vitamin E and immunity after the Kona Triathlon World Championship. Med Sci Sports Exerc. 2004;36(8):1328–35.PubMed
138.
Zurück zum Zitat Teixeira VH, Valente HF, Casal SI, Marques AF, Moreira PA. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Med Sci Sports Exerc. 2009;41(9):1752–60.PubMed Teixeira VH, Valente HF, Casal SI, Marques AF, Moreira PA. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Med Sci Sports Exerc. 2009;41(9):1752–60.PubMed
141.
Zurück zum Zitat Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, et al. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radic Biol Med. 2015;78:233–5.PubMed Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, et al. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radic Biol Med. 2015;78:233–5.PubMed
144.
Zurück zum Zitat Jiang Q, Cheng X, Cui Y, Xia Q, Yan X, Zhang M, et al. Resveratrol regulates skeletal muscle fibers switching through the AdipoR1–AMPK–PGC–1α pathway. Food Funct. 2019;10:3334–43.PubMed Jiang Q, Cheng X, Cui Y, Xia Q, Yan X, Zhang M, et al. Resveratrol regulates skeletal muscle fibers switching through the AdipoR1–AMPK–PGC–1α pathway. Food Funct. 2019;10:3334–43.PubMed
146.
Zurück zum Zitat Olesen J, Gliemann L, Biensø R, Schmidt J, Hellsten Y, Pilegaard H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol. 2014;592(8):1873–86.PubMedPubMedCentral Olesen J, Gliemann L, Biensø R, Schmidt J, Hellsten Y, Pilegaard H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol. 2014;592(8):1873–86.PubMedPubMedCentral
147.
Zurück zum Zitat Scribbans TD, Ma JK, Edgett BA, Vorobej KA, Mitchell AS, Zelt JG, et al. Resveratrol supplementation does not augment performance adaptations or fibre-type–specific responses to high-intensity interval training in humans. Appl Physiol Nutr Metab. 2014;39(11):1305–13.PubMed Scribbans TD, Ma JK, Edgett BA, Vorobej KA, Mitchell AS, Zelt JG, et al. Resveratrol supplementation does not augment performance adaptations or fibre-type–specific responses to high-intensity interval training in humans. Appl Physiol Nutr Metab. 2014;39(11):1305–13.PubMed
151.
Zurück zum Zitat Hodgson AB, Randell RK, Jeukendrup AE. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Adv Nutr. 2013;4(2):129–40.PubMedPubMedCentral Hodgson AB, Randell RK, Jeukendrup AE. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Adv Nutr. 2013;4(2):129–40.PubMedPubMedCentral
153.
Zurück zum Zitat Kuo Y-C, Lin J-C, Bernard JR, Liao Y-H. Green tea extract supplementation does not hamper endurance-training adaptation but improves antioxidant capacity in sedentary men. Appl Physiol Nutr Metab. 2015;40(10):990–6.PubMed Kuo Y-C, Lin J-C, Bernard JR, Liao Y-H. Green tea extract supplementation does not hamper endurance-training adaptation but improves antioxidant capacity in sedentary men. Appl Physiol Nutr Metab. 2015;40(10):990–6.PubMed
154.
Zurück zum Zitat van Loon LJ, Greenhaff PL, Constantin-Teodosiu D, Saris WH, Wagenmakers AJ. The effects of increasing exercise intensity on muscle fuel utilisation in humans. J Physiol. 2001;536(Pt 1):295–304.PubMedPubMedCentral van Loon LJ, Greenhaff PL, Constantin-Teodosiu D, Saris WH, Wagenmakers AJ. The effects of increasing exercise intensity on muscle fuel utilisation in humans. J Physiol. 2001;536(Pt 1):295–304.PubMedPubMedCentral
158.
Zurück zum Zitat Lee I, Hüttemann M, Kruger A, Bollig-Fischer A, Malek MH. (−)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice. Front Pharmacol. 2015;6:43.PubMedPubMedCentral Lee I, Hüttemann M, Kruger A, Bollig-Fischer A, Malek MH. (−)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice. Front Pharmacol. 2015;6:43.PubMedPubMedCentral
159.
Zurück zum Zitat Wadley GD, Nicolas MA, Hiam D, McConell GK. Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training. Am J Physiol Endocrinol Metab. 2013;304(8):E853–62.PubMed Wadley GD, Nicolas MA, Hiam D, McConell GK. Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training. Am J Physiol Endocrinol Metab. 2013;304(8):E853–62.PubMed
161.
Zurück zum Zitat Lane SC, Areta JL, Bird SR, Coffey VG, Burke LM, Desbrow B, et al. Caffeine ingestion and cycling power output in a low or normal muscle glycogen state. Med Sci Sports Exerc. 2013;45(8):1577–84.PubMed Lane SC, Areta JL, Bird SR, Coffey VG, Burke LM, Desbrow B, et al. Caffeine ingestion and cycling power output in a low or normal muscle glycogen state. Med Sci Sports Exerc. 2013;45(8):1577–84.PubMed
166.
Zurück zum Zitat Fredholm BB. Astra award lecture. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol. 1995;76(2):93–101.PubMed Fredholm BB. Astra award lecture. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol. 1995;76(2):93–101.PubMed
167.
Zurück zum Zitat Cole KJ, Costill DL, Starling RD, Goodpaster BH, Trappe SW, Fink WJ. Effect of caffeine ingestion on perception of effort and subsequent work production. Int J Sport Nutr. 1996;6(1):14–23.PubMed Cole KJ, Costill DL, Starling RD, Goodpaster BH, Trappe SW, Fink WJ. Effect of caffeine ingestion on perception of effort and subsequent work production. Int J Sport Nutr. 1996;6(1):14–23.PubMed
170.
Zurück zum Zitat Park S, Scheffler T, Rossie S, Gerrard D. AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity. Cell Calcium. 2013;53(3):217–23.PubMed Park S, Scheffler T, Rossie S, Gerrard D. AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity. Cell Calcium. 2013;53(3):217–23.PubMed
171.
Zurück zum Zitat Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, et al. CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—new mode of action for caffeine. PLoS Biol. 2018;16(6):e2004408.PubMedPubMedCentral Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, et al. CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—new mode of action for caffeine. PLoS Biol. 2018;16(6):e2004408.PubMedPubMedCentral
175.
Zurück zum Zitat Boyett JC, Giersch GE, Womack CJ, Saunders MJ, Hughey CA, Daley HM, et al. Time of day and training status both impact the efficacy of caffeine for short duration cycling performance. Nutrients. 2016;8(10):639.PubMedCentral Boyett JC, Giersch GE, Womack CJ, Saunders MJ, Hughey CA, Daley HM, et al. Time of day and training status both impact the efficacy of caffeine for short duration cycling performance. Nutrients. 2016;8(10):639.PubMedCentral
180.
Zurück zum Zitat Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). 1992;83(3):367–74.PubMed Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). 1992;83(3):367–74.PubMed
183.
Zurück zum Zitat Kuznetsov AV, Tiivel T, Sikk P, Kaambre T, Kay L, Daneshrad Z, et al. Striking differences between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. Eur J Biochem. 1996;241(3):909–15.PubMed Kuznetsov AV, Tiivel T, Sikk P, Kaambre T, Kay L, Daneshrad Z, et al. Striking differences between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. Eur J Biochem. 1996;241(3):909–15.PubMed
188.
Zurück zum Zitat Forbes SC, Sletten N, Durrer C, Myette-Côté É, Candow D, Little JP. Creatine Monohydrate supplementation does not augment fitness, performance, or body composition adaptations in response to four weeks of high-intensity interval training in young females. Int J Sport Nutr Exerc Metab. 2017;27(3):285–92.PubMed Forbes SC, Sletten N, Durrer C, Myette-Côté É, Candow D, Little JP. Creatine Monohydrate supplementation does not augment fitness, performance, or body composition adaptations in response to four weeks of high-intensity interval training in young females. Int J Sport Nutr Exerc Metab. 2017;27(3):285–92.PubMed
189.
Zurück zum Zitat McCracken M, Ainsworth B, Hackney AC. Effects of the menstrual cycle phase on the blood lactate responses to exercise. Eur J Appl Physiol Occup Physiol. 1994;69(2):174–5.PubMed McCracken M, Ainsworth B, Hackney AC. Effects of the menstrual cycle phase on the blood lactate responses to exercise. Eur J Appl Physiol Occup Physiol. 1994;69(2):174–5.PubMed
190.
Zurück zum Zitat Chwalbinska-Moneta J. Effect of creatine supplementation on aerobic performance and anaerobic capacity in elite rowers in the course of endurance training. Int J Sport Nutr Exerc Metab. 2003;13(2):173–83.PubMed Chwalbinska-Moneta J. Effect of creatine supplementation on aerobic performance and anaerobic capacity in elite rowers in the course of endurance training. Int J Sport Nutr Exerc Metab. 2003;13(2):173–83.PubMed
193.
Zurück zum Zitat Shill DD, Southern WM, Willingham TB, Lansford KA, McCully KK, Jenkins NT. Mitochondria-specific antioxidant supplementation does not influence endurance exercise training-induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake. J Physiol. 2016;594(23):7005–14.PubMedPubMedCentral Shill DD, Southern WM, Willingham TB, Lansford KA, McCully KK, Jenkins NT. Mitochondria-specific antioxidant supplementation does not influence endurance exercise training-induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake. J Physiol. 2016;594(23):7005–14.PubMedPubMedCentral
Metadaten
Titel
Effects of Dietary Supplements on Adaptations to Endurance Training
verfasst von
Jeffrey A. Rothschild
David J. Bishop
Publikationsdatum
17.09.2019
Verlag
Springer International Publishing
Erschienen in
Sports Medicine / Ausgabe 1/2020
Print ISSN: 0112-1642
Elektronische ISSN: 1179-2035
DOI
https://doi.org/10.1007/s40279-019-01185-8

Weitere Artikel der Ausgabe 1/2020

Sports Medicine 1/2020 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Medizinstudium Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärztinnen und Psychotherapeuten.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.