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Journal of Endocrinological Investigation
Erschienen in: Journal of Endocrinological Investigation 5/2022

01.05.2022 | Review

Effects of glycine on metabolic syndrome components: a review

verfasst von: M. Imenshahidi, H. Hossenzadeh

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 5/2022

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Abstract

Purpose

Glycine is the simplest and major amino acid in humans. It is mainly generated in the liver and kidney and is used to produce collagen, creatine, glucose and purine. It is also involved in immune function, anti-inflammatory processes and anti-oxidation reactions. Here, we reviewed the current evidence supporting the role of glycine in the development and treatment of metabolic syndrome components.

Methods

We searched Scopus, PubMed and EMBASE databases for papers concerning glycine and metabolic syndrome.

Results

Available evidence shows that the amount of glycine synthesized in vivo is insufficient to meet metabolic demands in these species. Plasma glycine levels are lower in subjects with metabolic syndrome than in healthy individuals. Interventions such as lifestyle modification, exercise, weight loss, or drugs that improve manifestations of metabolic syndrome remarkably increase circulating glycine concentrations.

Conclusion

Glycine supplementation improves various components of metabolic syndrome including diabetes, obesity, hyperlipidemia and hypertension. In the future, the use of glycine may have a significant clinical impact on the treatment of patients with metabolic syndrome.
Literatur
1.
Wang W, Wu Z, Dai Z, Yang Y, Wang J, Wu G (2013) Glycine metabolism in animals and humans: Implications for nutrition and health. Amino Acids 45:463–477PubMedCrossRef
2.
Adeva-Andany M, Souto-Adeva G, Ameneiros-Rodríguez E, Fernández-Fernández C, Donapetry-García C, Domínguez-Montero A (2018) Insulin resistance and glycine metabolism in humans. Amino Acids 50:11–27PubMedCrossRef
3.
Rezaei R, Wang W, Wu Z, Dai Z, Wang J, Wu G (2013) Biochemical and physiological bases for utilization of dietary amino acids by young Pigs. J Anim Sci Biotech 4:7CrossRef
4.
5.
6.
7.
Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, Bunzendaul H, Bradford B, Lemasters JJ (2003) L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care 6:229–240PubMedCrossRef
8.
9.
Yan-Do R, MacDonald PE (2017) Impaired “Glycine”-mia in type 2 diabetes and potential mechanisms contributing to glucose homeostasis. Endocrinol 158:1064–1073CrossRef
10.
Ito D, Kawazoe Y, Sato A, Uesugi M, Hirata H (2020) Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor. Sci Rep 10:13999PubMedPubMedCentralCrossRef
11.
Yan-Do R, Duong E, Manning Fox JE, Dai X, Suzuki K, Khan S, Bautista A, Ferdaoussi M, Lyon J, Wu X et al (2016) A glycine-insulin autocrine feedback loop enhances insulin secretion from human β-cells and is impaired in type 2 diabetes. Diabetes 65:2311–2321PubMedCrossRef
12.
Lynch JW (2004) Molecular structure and function of the glycine receptor chloride channel. Physiol Rev 84:1051–1095PubMedCrossRef
13.
Cornier M-A, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, Van Pelt RE, Wang H, Eckel RH (2008) The metabolic syndrome. Endocr Rev 29:777–822PubMedPubMedCentralCrossRef
14.
Tabeshpour J, Imenshahidi M, Hosseinzadeh H (2017) A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome. Iran J Basic Med Sci 20:557–568PubMedPubMedCentral
15.
Smith M, Honce R, Schultz-Cherry S (2020) Metabolic Syndrome and Viral Pathogenesis: Lessons from Influenza and Coronaviruses. J Virol 94:e00665-e720PubMedPubMedCentralCrossRef
16.
Bovolini A, Garcia J, Andrade MA, Duarte JA (2021) Metabolic syndrome pathophysiology and predisposing factors. Int J Sports Med 42:199–214PubMedCrossRef
17.
Gh MAS, Wong RJ (2020) Trends in the prevalence of metabolic syndrome in the United States, 2011–2016. JAMA 23:2526–2528
18.
Nittari G, Scuri S, Petrelli F, Pirillo I, di Luca NM, Grappasonni I (2019) Fighting obesity in children from European World Health Organization member states. Epidemiological data, medical-social aspects, and prevention programs. Clin Ter 170:e223–e230PubMed
19.
Emilio Greco E, Meo F, Cedrone F (2020) Gender differences in childhood bmi z-score, alimentary behaviour and lifestyle in a sample of 9–11 children. Clin Ter 171:425–430
20.
Redon J, Cifkova R, Laurent S, Nilsson P, Narkiewicz K, Erdine S, Mancia G (2004) The metabolic syndrome in hypertension: European society of hypertension position statement. J Hypertens 26:1891CrossRef
21.
Wagh A, Stone NJ (2004) Treatment of metabolic syndrome. Expert Rev Cardiovasc Ther 2:213–228PubMedCrossRef
22.
Imenshahidi M, Karimi G, Hosseinzadeh H (2020) Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review. Naunyn Schmiedebergs Arch Pharmacol 393:521–536PubMedCrossRef
23.
Razavi BM, Hosseinzadeh H (2014) A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome. J Endocrinol Invest 37:1031–1040PubMedCrossRef
24.
Tajmohammadi A, Razavi BM, Hosseinzadeh H (2018) Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: a review. Phytother Res 32:1933–1949PubMedCrossRef
25.
Takashina C, Tsujino I, Watanabe T, Sakaue S, Ikeda D, Yamada A, Sato T, Ohira H, Otsuka Y, Oyama-Manabe N et al (2016) Associations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose tolerance. Nutr Metab 13:5CrossRef
26.
Glynn EL, Piner LW, Huffman KM, Slentz CA, Elliot-Penry L, AbouAssi H, White PJ, Bain JR, Muehlbauer MJ, Ilkayeva OR et al (2015) Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans. Diabetologia 58:2324–2335PubMedPubMedCentralCrossRef
27.
Li X, Sun L, Zhang W, Li H, Wang S, Mu H, Zhou Q, Zhang Y, Tang Y, Wang Y et al (2018) Association of serum glycine levels with metabolic syndrome in an elderly Chinese population. Nutr Metab 15:1CrossRef
28.
Alves A, Bassot A, Bulteau A, Pirola L, Morio B (2019) Glycine metabolism and its alterations in obesity and metabolic diseases. Nutrients 11:1356PubMedCentralCrossRef
29.
Iverson JF, Gannon MC (2014) Interaction of ingested leucine with glycine on insulin and glucose concentrations. J Amino Acids 4:521941
30.
Seibert R, Abbasi F, Hantash FM, Caulfield MP, Reaven G, Kim SH (2015) Relationship between insulin resistance and amino acids in women and men. Physiol Rep 3:e12392PubMedPubMedCentralCrossRef
31.
Thalacker-Mercer AE, Ingram KH, Guo F, Ilkayeva O, Newgard CB, Garvey WT (2014) BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans. Diabetes 63:791–800PubMedPubMedCentralCrossRef
32.
Perseghin G, Ghosh S, Gerow K, Shulman GI (1997) Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study. Diabetes 46:1001–1009PubMedCrossRef
33.
Wang Q, Lu K, Du H, Zhang Q, Chen T, Shu Y, Hua Y, Zhu L (2014) Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis. Biomed Pharmacother 68:757–762PubMedCrossRef
34.
Alvarado-Vásquez N, Zamudio P, Cerón E, Vanda B, Zenteno E, Carvajal-Sandoval G (2003) Effect of glycine in streptozotocin-induced diabetic rats. Comp Biochem Physiol C Toxicol 134:521–527CrossRef
35.
Cerón E, Bernal-Alcántara D, Vanda B, Sommer B, Gonzalez-Trujano E, Alvarado-Vásquez N (2020) Glycine supplementation during six months does not alter insulin, glucose or triglycerides plasma levels in healthy rats. Aging Cell 20:1–10
36.
Carvajal Sandoval G, Juárez E, Ramos Martínez G, Carvajal Juárez ME, Medina-Santillán R (1999) Inhibition of hemoglobin glycation with glycine in induced diabetes mellitus in rats. Proc West Pharmacol Soc 42:35–36PubMed
37.
Cruz M, Maldonado-Bernal C, Mondragón-Gonzalez R, Sanchez-Barrera R, Wacher NH, Carvajal-Sandoval G, Kumate J (2008) Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes. J Endocrinol Invest 31:694–699PubMedCrossRef
38.
González-Ortiz M, Medina-Santillán R, Martínez-Abundis E, von Drateln CR (2001) Effect of glycine on insulin secretion and action in healthy first-degree relatives of type 2 diabetes mellitus patients. Horm Metab Res 33:358–360PubMedCrossRef
39.
El-Hafidi M, Franco M, Ramírez AR, Sosa JS, Flores JAP, Acosta OL, Salgado MC, Cardoso-Saldaña G (2018) Glycine increases insulin sensitivity and glutathione biosynthesis and protects against oxidative stress in a model of sucrose-induced insulin resistance. Oxid Med Cell Longev 2018:2101562PubMedPubMedCentralCrossRef
40.
Nguyen D, Hsu JW, Jahoor F, Sekhar RV (2014) Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. J Clin Endocrinol Metab 99:169–177PubMedCrossRef
41.
Wang Z, Zhang J, Wang L, Li W, Chen L, Li J, Zhao D, Zhang H, Guo X (2018) Glycine mitigates renal oxidative stress by suppressing Nox4 expression in rats with streptozotocin-induced diabetes. J Pharmacol Sci 137:387–394PubMedCrossRef
42.
Etoh T, Inoguchi T, Kakimoto M, Sonoda N, Kobayashi K, Kuroda J, Sumimoto H, Nawata H (2003) Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment. Diabetologia 46:1428–1437PubMedCrossRef
43.
Tengholm A, McClenaghan N, Grapengiesser E, Gylfe E, Hellman B (1992) Glycine transformation of Ca2+ oscillations into a sustained increase parallels potentiation of insulin release. Biochim Biophys Acta 1137:243–247PubMedCrossRef
44.
45.
46.
Esser N, Paquot N, Scheen AJ (2015) Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opin Investig Drugs 24:283–307PubMedCrossRef
47.
Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98–107PubMedCrossRef
48.
Sekhar RV, McKay SV, Patel SG, Guthikonda AP, Reddy VT, Balasubramanyam A, Jahoor F (2011) Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine. Diabetes Care 34:162–167PubMedCrossRef
49.
50.
Van den Eynden J, Ali SS, Horwood N, Carmans S, Brône B, Hellings N, Steels P, Harvey RJ, Rigo JM (2009) Glycine and glycine receptor signalling in non-neuronal cells. Front Mol Neurosci 2:9PubMed
51.
Kawai N, Bannai M, Seki S, Koizumi T, Shinkai K, Nagao K, Matsuzawa D, Takahashi M, Shimizu E (2012) Pharmacokinetics and cerebral distribution of glycine administered to rats. Amino Acids 42:2129–2137PubMedCrossRef
52.
D’Souza DC, Gil R, Cassello K, Morrissey K, Abi-Saab D, White J, Sturwold R, Bennett A, Karper LP, Zuzarte E et al (2000) IV glycine and oral D-cycloserine effects on plasma and CSF amino acids in healthy humans. Biol Psychiatry 47:450–462PubMedCrossRef
53.
Lam CKL, Chari M, Su BB, Cheung GWC, Kokorovic A, Yang CS, Wang PYT, Lai TYY, Lam TKT (2010) Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production. J Biol Chem 285:21913–21921PubMedPubMedCentralCrossRef
54.
Abraham MA, Filippi BM, Kang GM, Kim MS, Lam TK (2014) Insulin action in the hypothalamus and dorsal vagal complex. Exp Physiol 99:1104–1109PubMedCrossRef
55.
Yue JTY, Abraham MA, Bauer PV, LaPierre MP, Wang P, Duca FA, Filippi BM, Chan O, Lam TKT (2016) Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity. Nat Commun 7:13501PubMedPubMedCentralCrossRef
56.
Nuttall FQ, Yue JT, Abraham MA, Bauer PV, LaPierre MP, Wang P, Duca FA, Filippi BM, Chan O, Lam TK (2016) Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity. J Amino Acids 7:13501
57.
Gholami S, Kamali Y (2019) Glycine supplementation ameliorates retinal neuronal damage in an experimental model of diabetes in rats: a light and electron microscopic study. J Ophthalmic Vis Res 14:448–456PubMedPubMedCentral
58.
59.
Morales-Calixto E, Velázquez-Flores M, Sánchez-Chávez G, Ruiz Esparza-Garrido R, Salceda R (2019) Glycine receptor is differentially expressed in the rat retina at early stages of streptozotocin-induced diabetes. Neurosci Lett 712:134506PubMedCrossRef
60.
Ramakrishnan S, Sulochana KN (1993) Decrease in glycation of lens proteins by lysine and glycine by scavenging of glucose and possible mitigation of cataractogenesis. Exp Eye Res 57:623–628PubMedCrossRef
61.
Bahmani F, Bathaie SZ, Aldavood SJ, Ghahghaei A (2012) Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats. Mol Vis 18:439–448PubMedPubMedCentral
62.
Yue JT, Mighiu PI, Naples M, Adeli K, Lam TK (2012) Glycine normalizes hepatic triglyceride-rich VLDL secretion by triggering the CNS in high-fat fed rats. Circ Res 110:1345–1354PubMedCrossRef
63.
Venkatesh R, Srinivasan K, Singh SA (2017) Effect of arginine:lysine and glycine:methionine intake ratios on dyslipidemia and selected biomarkers implicated in cardiovascular disease: a study with hypercholesterolemic rats. Biomed Pharmacother 91:408–414PubMedCrossRef
64.
El Hafidi M, Pérez I, Zamora J, Soto V, Carvajal-Sandoval G, Baños G (2004) Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. Am J Physiol Regul Integr Comp Physiol 287:R1387-1393PubMedCrossRef
65.
Park T, Oh J, Lee K (1999) Dietary taurine or glycine supplementation reduces plasma and liver cholesterol and triglyceride concentrations in rats fed a cholesterol-free diet. Nutr Res 19:1777–1789CrossRef
66.
Lam CKL, Chari M, Rutter GA, Lam TKT (2011) Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivo. Diabetes 60:107–113PubMedCrossRef
67.
O’Byrne J, Hunt MC, Rai DK, Saeki M, Alexson SE (2003) The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine. J Biol Chem 278:34237–34244PubMedCrossRef
68.
Yagasaki K, Machida-Takehana M, Funabiki R (1990) Effects of dietary methionine and glycine on serum lipoprotein profiles and fecal sterol excretion in normal and hepatoma-bearing rats. J Nutr Sci Vitaminol 36:45–54PubMedCrossRef
69.
Liao YJ, Chen TL, Lee TS, Wang HA, Wang CK, Liao LY, Liu RS, Huang SF, Chen YM (2012) Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. Mol Med (Cambridge, Mass) 18:412–422CrossRef
70.
Stickel F, Hellerbrand C (2010) Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications. Gut 59:1303–1307PubMedCrossRef
71.
72.
Simonen P, Kotronen A, Hallikainen M, Sevastianova K, Makkonen J, Hakkarainen A, Lundbom N, Miettinen TA, Gylling H, Yki-Järvinen H (2011) Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. J Hepatol 54:153–159PubMedCrossRef
73.
74.
Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, Villacorta L, Fan Y, Chang L, Wang L et al (2020) Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. Sci Transl Med 12:572CrossRef
75.
Barakat HA, Hamza AH (2012) Glycine alleviates liver injury induced by deficiency in methionine and or choline in rats. Eur Rev Med Pharmacol Sci 16:728–736PubMed
76.
Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA et al (2009) A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 9:311–326PubMedPubMedCentralCrossRef
77.
Suzuki Y, Kido J, Matsumoto S, Shimizu K, Nakamura K (2019) Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity. BMC Pediatr 19:273–273PubMedPubMedCentralCrossRef
78.
Almanza-Perez JC, Alarcon-Aguilar FJ, Blancas-Flores G, Campos-Sepulveda AE, Roman-Ramos R, Garcia-Macedo R, Cruz M (2010) Glycine regulates inflammatory markers modifying the energetic balance through PPAR and UCP-2. Biomed Pharmacother 64:534–540PubMedCrossRef
79.
Dong J, López YR, Pérez-Torres I, Zúñiga-Muñoz A, Lans VG, Díaz-Díaz E, Castro ES, Espejel RV (2016) Effect of glycine on adipocyte hypertrophy in a metabolic syndrome rat model. Nutr Metab (Lond) 13:158–169
80.
Morse SA, Zhang R, Thakur V, Reisin E (2005) Hypertension and the metabolic syndrome. Am J Med Sci 330:303–310PubMedCrossRef
81.
Ruiz-Ramírez A, Ortiz-Balderas E, Cardozo-Saldaña G, Diaz-Diaz E, El-Hafidi M (2014) Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats. Clin Sci 126:19–29CrossRef
82.
Quan H, Athirakul K, Wetsel WC, Torres GE, Stevens R, Chen YT, Coffman TM, Caron MG (2004) Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. Mol Cell Biol 24:4166–4173PubMedPubMedCentralCrossRef
83.
El Hafidi M, Pérez I, Baños G (2006) Is glycine effective against elevated blood pressure? Curr Opin Clin Nutr Metab Care 9:26–31PubMedCrossRef
84.
Díaz-Flores M, Cruz M, Duran-Reyes G, Munguia-Miranda C, Loza-Rodríguez H, Pulido-Casas E, Torres-Ramírez N, Gaja-Rodriguez O, Kumate J, Baiza-Gutman LA, Hernández-Saavedra D (2013) Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Can J Physiol Pharmacol 91:855–860PubMedCrossRef
85.
Guertzenstein PG, Silver A (1974) Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions. J Physiol 242:489–503PubMedPubMedCentralCrossRef
86.
Stamler J, Brown IJ, Daviglus ML, Chan Q, Miura K, Okuda N, Ueshima H, Zhao L, Elliott P (2013) Dietary glycine and blood pressure: the International Study on Macro/Micronutrients and Blood Pressure. Am J Clin Nutr 98:136–145PubMedPubMedCentralCrossRef
87.
Mishra RC, Tripathy S, Quest D, Desai KM, Akhtar J, Dattani ID, Gopalakrishnan V (2008) L-Serine lowers while glycine increases blood pressure in chronic L-NAME-treated and spontaneously hypertensive rats. J Hypertens 26:2339–2348PubMedCrossRef
88.
Kubo T, Kihara M (1990) Beta-alanine, like glycine, microinjected into the rat nucleus tractus solitarii increases blood pressure. Clin Exp Hypertens A 12:1351–1360PubMed
89.
Jackson AA, Dunn RL, Marchand MC, Langley-Evans SC (2002) Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine. Clin Sci (Lond) 103:633–639CrossRef
90.
Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G et al (2016) Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nat Mater 15:335–343PubMedPubMedCentralCrossRef
91.
Ding Y, Svingen GFT, Pedersen ER, Gregory JF, Ueland PM, Tell GS, Nygård OK (2016) Plasma glycine and risk of acute myocardial infarction in patients with suspected stable angina pectoris. J Am Heart Assoc 5:e002621CrossRef
92.
Gannon MC, Nuttall JA, Nuttall FQ (2002) The metabolic response to ingested glycine. Am J Clin Nutr 76:1302–1307PubMedCrossRef
Metadaten
Titel
Effects of glycine on metabolic syndrome components: a review
verfasst von
M. Imenshahidi
H. Hossenzadeh
Publikationsdatum
01.05.2022
Verlag
Springer International Publishing
Erschienen in
Journal of Endocrinological Investigation / Ausgabe 5/2022
Elektronische ISSN: 1720-8386
DOI
https://doi.org/10.1007/s40618-021-01720-3

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