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European Archives of Oto-Rhino-Laryngology

Erschienen in:

22.02.2021 | Laryngology

Effects of hyaluronic acid-collagen nanofibers on early wound healing in vocal cord trauma

verfasst von: Elif Elibol, Yavuz Fuat Yılmaz, Adnan Ünal, Müge Ozcan, Nurcan Yurtsever Kum, Rauf Oğuzhan Kum, Sezer Kulaçoğlu

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2021

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Abstract

Background

Vocal cord scarring is the most crucial obstacle in voice quality after surgery. This study aimed to evaluate the effectiveness of hyaluronic acid (HA)-collagen nanofibers on the healing of vocal cords after surgical trauma.

Method

Right vocal cords of 12 New Zealand white rabbits were traumatized, and the experimental group was received 1.08 mg/75 ml topical HA-collagen nanofiber (Gelfix^® spray) for 3 days. Three animals in each group were sacrificed on the 7th day, and the remaining of the animals were sacrificed on the 21st day. The laryngeal specimens in the experimental and control groups were examined histopathologically.

Result

The 7th-day H&E staining evaluation revealed pink, dense, and thin collagen fibers. Besides, the collagen content was scattered and irregular in the experimental group. The 21st-day assessment showed that the collagen bundles in the granulation tissue were almost with the same formation in both of the groups. Masson Trichrome staining on the 7^th day of the study showed that the collagen fiber bundles were less frequent in the control group than the experimental group. The 7th-day Van Gieson staining analysis showed that the pattern of reticular fibers was more regular with the parallel formation in the experimental group than the control group.

Conclusion

HA-collagen nanofiber can be used in diseases that impair voice quality due to the thickening of the lamina propria layer in the vocal cord and impaired viscoelasticity due to fibrosis after tissue trauma.

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Titel: Effects of hyaluronic acid-collagen nanofibers on early wound healing in vocal cord trauma
verfasst von: Elif Elibol
Yavuz Fuat Yılmaz
Adnan Ünal
Müge Ozcan
Nurcan Yurtsever Kum
Rauf Oğuzhan Kum
Sezer Kulaçoğlu
Publikationsdatum: 22.02.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2021
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-021-06703-x

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Effects of hyaluronic acid-collagen nanofibers on early wound healing in vocal cord trauma