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01.09.2011 | Original Paper

Effects of oxcarbazepine on monoamines content in hippocampus and head and body shakes and sleep patterns in kainic acid-treated rats

verfasst von: Alfonso Alfaro-Rodríguez, Rigoberto González-Piña, Antonio Bueno-Nava, Emilio Arch-Tirado, Alberto Ávila-Luna, Rebeca Uribe-Escamilla, Javier Vargas-Sánchez

Erschienen in: Metabolic Brain Disease | Ausgabe 3/2011

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Abstract

The aim of this work was to analyze the effect of oxcarbazepine (OXC) on sleep patterns, “head and body shakes” and monoamine neurotransmitters level in a model of kainic-induced seizures. Adult Wistar rats were administered kainic acid (KA), OXC or OXC + KA. A polysomnographic study showed that KA induced animals to stay awake for the whole initial 10 h. OXC administration 30 min prior to KA diminished the effect of KA on the sleep parameters. As a measure of the effects of the drug treatments on behavior, head and body shakes were visually recorded for 4 h after administration of KA, OXC + KA or saline. The presence of OXC diminished the shakes frequency. 4 h after drug application, the hippocampus was dissected out, and the content of monoamines was analyzed. The presence of OXC still more increased serotonin, 5-hidroxyindole acetic acid, dopamine, and homovanilic acid, induced by KA.

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Titel: Effects of oxcarbazepine on monoamines content in hippocampus and head and body shakes and sleep patterns in kainic acid-treated rats
verfasst von: Alfonso Alfaro-Rodríguez
Rigoberto González-Piña
Antonio Bueno-Nava
Emilio Arch-Tirado
Alberto Ávila-Luna
Rebeca Uribe-Escamilla
Javier Vargas-Sánchez
Publikationsdatum: 01.09.2011
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 3/2011
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-011-9254-x

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