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Metabolic Brain Disease

Metabolic Brain Disease OnlineFirst articles

27.07.2021 | Review Article

Role of metals in Alzheimer’s disease

Metal homeostasis in the central nervous system (CNS) is a crucial component of healthy brain function, because metals serve as enzymatic cofactors and are key components of intra- and inter-neuronal signaling. Metal dysregulation wreaks havoc on …

26.07.2021 | Original Article

Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice

Thymoquinone (Tq), an active compound of Nigella sativa, has been known for its anti-inflammatory, antioxidant, and neuroprotective characteristics. The present study is aimed to evaluate the effect of Tq on reserpine (Rsp)-induced behavioral …

24.07.2021 | Original Article

Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

The hydrogen/deuterium exchange (HDX) is a reliable method to survey the dynamic behavior of proteins and epitope mapping. Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) is a quantifying tool to assay …

21.07.2021 | Original Article

Hereditary and non-hereditary etiologies associated with extensive brain calcification: case series

Cerebral calcification may be caused by several potentially treatable conditions, however, in most cases it does not receive special attention in clinical practice. From the point of view of etiology, the diseases associated with cerebral …

17.07.2021 | Original Article

Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway

Diabetes-associated affective disorders are of wide concern, and oxidative stress plays a vital role in the pathological process. This study was to investigate the cerebroprotective effects of hesperetin against anxious and depressive disorders …

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Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on brain diseases, including both human and animal studies. Topics include, but are not limited to, stroke, traumatic brain injury, myelin disorders, epilepsy, multiple sclerosis, toxic encephalopathies, genetic diseases affecting the brain, alcohol and brain metabolism, neuroendocrinopathies, viral and nonviral encephalitides, nutritional disorders affecting the brain, diseases affecting neurotransmitters, Alzheimer's disease, Parkinson’s disease, amyotrophic lateral sclerosis and aging. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to neuroscientists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of brain disorders.

Metabolic Brain Disease will consider Full Research Papers, Short Communications, Review Articles and Editorials. The journal is committed to high standards of presentation. Please contact the Editor to discuss the suitability of topics.

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