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Metabolic Brain Disease

Metabolic Brain Disease OnlineFirst articles

01.08.2020 | Original Article Open Access

Mitochondrial genome variation in male LHON patients with the m.11778G > A mutation

Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder with symptoms limited to a single tissue, optic nerve, resulting in vision loss. In the majority of cases it is caused by one of three point mutations in mitochondrial DNA …

21.07.2020 | Original Article

Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats

Intracerebroventricular (ICV) injection of streptozotocin (STZ) is a well established procedure to induce neuroinflammation leading to dementia in experimental animals. However, the optimal dose of STZ has not been determined. In the present …

21.07.2020 | Original Article

Melatonin regulates neurodegenerative complications associated with NAFLD via enhanced neurotransmission and cellular integrity: a correlational study

Nonalcoholic fatty liver disease (NAFLD) is recognized globally as the leading cause of chronic liver diseases whose patients are asymptomatic and are diagnosed incidentally. It increases the rate of mortality which is usually related to …

17.07.2020 | Review Article

Pathogenesis and promising therapeutics of Alzheimer disease through eIF2α pathway and correspondent kinases

Eukaryotic initiation factor 2 (eIF2α) pathway is overactivated in Alzheimer disease and is probably associated with synaptic and memory deficiencies. EIF2α protein is principally in charge of the regulation of protein synthesis in eukaryotic …

16.07.2020 | Original Article

A combination of an antioxidant with a prebiotic exerts greater efficacy than either as a monotherapy on cognitive improvement in castrated-obese male rats

Previous studies by ourselves and others have demonstrated that both obesity and testosterone deprivation have been related to cognitive decline. We have also shown that a prebiotic and n-acetyl cysteine (NAC) improved cognitive dysfunction in …

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Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on brain diseases, including both human and animal studies. Topics include, but are not limited to, stroke, traumatic brain injury, myelin disorders, epilepsy, multiple sclerosis, toxic encephalopathies, genetic diseases affecting the brain, alcohol and brain metabolism, neuroendocrinopathies, viral and nonviral encephalitides, nutritional disorders affecting the brain, diseases affecting neurotransmitters, Alzheimer's disease, Parkinson’s disease, amyotrophic lateral sclerosis and aging. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to neuroscientists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of brain disorders.

Metabolic Brain Disease will consider Full Research Papers, Short Communications, Review Articles and Editorials. The journal is committed to high standards of presentation. Please contact the Editor to discuss the suitability of topics.

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Neu in den Fachgebieten Neurologie und Psychiatrie