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Metabolic Brain Disease

Metabolic Brain Disease OnlineFirst articles

27.11.2020 | Original Article

Region-selective permeability of the blood-brain barrier to α-aminoisobutyric acid during thiamine deficiency and following its reversal

Thiamine deficiency (TD) results in focal lesions in several regions of the rat brain including the thalamus and inferior colliculus. Since alterations in blood-brain barrier (BBB) integrity may play a role in this damage, we have examined the …

21.11.2020 | Original Article

The effects of lithium chloride and cathodal/anodal transcranial direct current stimulation on conditional fear memory changes and the level of p-mTOR/mTOR in PFC of male NMRI mice

Lithium chloride clinically used to treat mental diseases but it has some side effects like cognitive impairment, memory deficit. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that is able to change …

21.11.2020 | Original Article

Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose

The present study aimed to evaluate the effect of folic acid treatment in an animal model of aging induced by D-galactose (D-gal). For this propose, adult male Wistar rats received D-gal intraperitoneally (100 mg/kg) and/or folic acid orally (5 …

19.11.2020 | Original Article

Physical exercise prevents amyloid β1−40-induced disturbances in NLRP3 inflammasome pathway in the hippocampus of mice

Amyloid beta (Aβ), one of the main hallmarks of Alzheimer’s Disease (AD), may stimulate pattern recognition receptors (PRR) such as the NLRP3 inflammasome, inducing a pro-inflammatory state in the brain that contributes to disease development.

17.11.2020 | Review Article

Crossing the blood-brain barrier with AAV vectors

Central nervous system (CNS) diseases are some of the most difficult to treat because the blood-brain barrier (BBB) almost entirely limits the passage of many therapeutic drugs into the CNS. Gene therapy based on the adeno-associated virus (AAV) …

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Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on brain diseases, including both human and animal studies. Topics include, but are not limited to, stroke, traumatic brain injury, myelin disorders, epilepsy, multiple sclerosis, toxic encephalopathies, genetic diseases affecting the brain, alcohol and brain metabolism, neuroendocrinopathies, viral and nonviral encephalitides, nutritional disorders affecting the brain, diseases affecting neurotransmitters, Alzheimer's disease, Parkinson’s disease, amyotrophic lateral sclerosis and aging. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to neuroscientists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of brain disorders.

Metabolic Brain Disease will consider Full Research Papers, Short Communications, Review Articles and Editorials. The journal is committed to high standards of presentation. Please contact the Editor to discuss the suitability of topics.

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Neu in den Fachgebieten Neurologie und Psychiatrie