nach oben

Erschienen in:

10.07.2019 | Review

Effects of physical exercise on oxidative stress biomarkers in hypertensive animals and non-diabetic subjects with prehypertension/hypertension: a review

verfasst von: F. Vicencio, P. Jiménez, F. Huerta, C. Cofré-Bolados, S. Gutiérrez Zamorano, D. F. Garcia-Diaz, R. Rodrigo, C. Poblete-Aro

Erschienen in: Sport Sciences for Health | Ausgabe 3/2019

Einloggen, um Zugang zu erhalten

Abstract

Background

Oxidative stress (OS) is a condition that alters different functions of the organism inducing high blood pressure (HBP). Although physical exercise is recommended for the treatment of HBP, it is not clear which exercise method is more efficient to reduce OS biomarkers in subjects with HBP and non-type 2 diabetes mellitus (T2DM). Therefore, this review aimed to determine the effect of physical exercise on the OS biomarkers of HBP animal models and non-T2DM prehypertensive/hypertensive human adults.

Methodology

An online search was done in WoS, Scopus and PubMed (MeSH) databases with the following combination of keywords: “hypertension” AND “oxidative stress” AND “exercise”.

Results

A total of 1128 articles were identified, from which only six articles on animal research and six on human research fulfilled the inclusion and exclusion criteria. In animal models, exercise reduced OS biomarkers and decreased systolic blood pressure. In humans, five of these articles showed a significant decrease in OS biomarkers along with a decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) and a single study found an increase in OS biomarkers co-occurring with a decrease in SBP/DBP.

Conclusions

Based on the analyzed articles, it is concluded that physical exercise, in its different modalities, allows the reduction of OS biomarkers, together with a significant decrease in SBP/DBP. Moderate intensity aerobic exercise presents a higher body of evidence compared to resistance training and flexibility training. For this reason, it is recommended to conduct more randomized clinical trials with these last two methods.

Oparil S, Acelajado MC, Bakris GL et al (2018) Hypertension. Nat Rev Dis Prim 4:1–21. https://doi.org/10.1038/nrdp.2018.14 CrossRef

Matsuda M, Shimomura I (2014) Roles of oxidative stress, adiponectin, and nuclear hormone receptors in obesity-associated insulin resistance and cardiovascular risk. Horm Mol Biol Clin Investig 19:75–88. https://doi.org/10.1515/hmbci-2014-0001 CrossRefPubMed

González J, Valls N, Brito R, Rodrigo R (2014) Essential hypertension and oxidative stress: new insights. World J Cardiol 6:353–366. https://doi.org/10.4330/wjc.v6.i6.353 CrossRefPubMedPubMedCentral

Bonomini F, Rodella LF, Rezzani R (2015) Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis 6:109–120. https://doi.org/10.14336/AD.2014.0305 CrossRefPubMedPubMedCentral

Rodrigo R, Brito R, González J (2016) Oxidative stress and essential hypertension. Update Essent Hypertens. https://doi.org/10.5772/64079 CrossRef

Gomes EC, Silva AN, De Oliveira MR (2012) Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev. https://doi.org/10.1155/2012/756132 CrossRefPubMedPubMedCentral

Marseglia L, Manti S, D’Angelo G et al (2015) Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci 16:378–400. https://doi.org/10.3390/ijms16010378 CrossRef

Pisoschi AM, Pop A (2015) The role of antioxidants in the chemistry of oxidative stress: a review. Eur J Med Chem 97:55–74. https://doi.org/10.1016/j.ejmech.2015.04.040 CrossRefPubMed

Steinbacher P, Eckl P (2015) Impact of oxidative stress on exercising skeletal muscle. Biomolecules 5:356–377. https://doi.org/10.3390/biom5020356 CrossRefPubMedPubMedCentral

10.

Poblete-Aro C, Russel-Guzmán J, Parra P et al (2018) Efecto del ejercicio físico sobre marcadores de estrés oxidativo en pacientes con diabetes mellitus tipo 2. Rev Med Chile 146:362–372CrossRefPubMed

11.

Rodrigo R, Prat H, Passalacqua W et al (2008) Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension. Clin Sci 114:625–634. https://doi.org/10.1042/CS20070343 CrossRef

12.

Domenech RJ (2006) Preconditioning: a new concept about the benefit of exercise. Circulation 113:105–108. https://doi.org/10.1161/CIRCULATIONAHA.105.569863 CrossRef

13.

Wang C-H, Wu S-B, Wu Y-T, Wei Y-H (2013) Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging. Exp Biol Med (Maywood) 238:450–460. https://doi.org/10.1177/1535370213493069 CrossRef

14.

Rodrigo R (2009) Oxidative stress and antioxidants, 1st edn. Nova, New York

15.

Rodrigo R (2014) Advances in hypertension research. Nova Science Publishers, New York

16.

Lacy F, Kailasam MT, Connor DTO et al (2000) Plasma hydrogen peroxide production in human essential hypertension. Hypertension 36:878–885CrossRefPubMed

17.

Liebert MA, Tanito M, Nakamura H et al (2004) Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats. Antioxid Redox Signal 6:89–97CrossRef

18.

Kaneto H, Katakami N, Matsuhisa M, Matsuoka T (2010) Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediat Inflamm 2010:453892. https://doi.org/10.1155/2010/453892 CrossRef

19.

Szostak J, Laurant P (2011) The forgotten face of regular physical exercise: a “natural” anti-atherogenic activity. Clin Sci (Lond) 121:91–106. https://doi.org/10.1042/CS20100520 CrossRef

20.

Smith DL, Fernhall B (2011) Advanced cardiovascular exercise physiology, 1st edn. Human Kinetics, Champaign

21.

Zuo L, Pannell BK (2015) Redox characterization of functioning skeletal muscle. Front Physiol 6:338. https://doi.org/10.3389/fphys.2015.00338 CrossRefPubMedPubMedCentral

22.

Muller FL, Liu Y, Van Remmen H (2004) Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 279:49064–49073. https://doi.org/10.1074/jbc.M407715200 CrossRefPubMed

23.

Gallego-Villar L, Rivera-Barahona A, Cuevas-Martín C et al (2016) In vivo evidence of mitochondrial dysfunction and altered redox homeostasis in a genetic mouse model of propionic acidemia: implications for the pathophysiology of this disorder. Free Radic Biol Med 96:1–12. https://doi.org/10.1016/j.freeradbiomed.2016.04.007 CrossRefPubMed

24.

Kuo HM, Weng SW, Chang AYW et al (2016) Altered mitochondrial dynamics and response to insulin in cybrid cells harboring a diabetes-susceptible mitochondrial DNA haplogroup. Free Radic Biol Med 96:116–129. https://doi.org/10.1016/j.freeradbiomed.2016.04.019 CrossRefPubMed

25.

Garnier A, Fortin D, Zoll J et al (2005) Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle. FASEB J 19:43–52. https://doi.org/10.1096/fj.04-2173com CrossRefPubMed

26.

American Society of Hypertension (1994) American journal of hypertension. Elsevier, Amsterdam

27.

Ji LL, Kang C, Zhang Y (2016) Exercise-induced hormesis and skeletal muscle health. Free Radic Biol Med 98:113–122. https://doi.org/10.1016/j.freeradbiomed.2016.02.025 CrossRefPubMed

28.

Schieber M, Chandel NS (2014) ROS function in redox signaling and oxidative stress. Curr Biol 24:R453–R462. https://doi.org/10.1016/j.cub.2014.03.034 CrossRefPubMedPubMedCentral

29.

Thirupathi A (2017) Multi-regulatory network of ROS : the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise. J Physiol Biochem 73:487–494. https://doi.org/10.1007/s13105-017-0576-y CrossRefPubMed

30.

Bellezza I, Giambanco I, Minelli A, Donato R (2018) Nrf2-Keap1 signaling in oxidative and reductive stress. BBA Mol Cell Res 1865:721–733

31.

Henríquez-Olguín C, Díaz-Vegas A, Utreras-Mendoza Y et al (2016) NOX2 inhibition impairs early muscle gene expression induced by a single exercise bout. Front Physiol. https://doi.org/10.3389/fphys.2016.00282 CrossRefPubMedPubMedCentral

32.

Guo S, Wharton W, Moseley P, Shi H (2007) Heat shock protein 70 regulates cellular redox status by modulating glutathione-related enzyme activities. Cell Stress Chaperones 12:245–254CrossRefPubMedPubMedCentral

33.

De Morton NA (2009) The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Aust J Physiother 55:129–133. https://doi.org/10.1016/S0004-9514(09)70043-1 CrossRef

34.

Bertagnolli M, Schenkel PC, Campos C et al (2008) Exercise training reduces sympathetic modulation on cardiovascular system and cardiac oxidative stress in spontaneously hypertensive rats. Am J Hypertens 21:1188–1193. https://doi.org/10.1038/ajh.2008.270 CrossRefPubMed

35.

Kimura H, Kon N, Furukawa S et al (2010) Effect of endurance exercise training on oxidative stress in spontaneously hypertensive rats (SHR) after emergence. Clin Exp Hypertens 32:407–415. https://doi.org/10.3109/10641961003667930 CrossRefPubMed

36.

Henrique L, De Andrade S, Max W et al (2015) Aerobic exercise training improves oxidative stress and ubiquitin-proteasome system activity in heart of spontaneously hypertensive rats. Mol Cell Biochem. https://doi.org/10.1007/s11010-015-2326-1 CrossRef

37.

Campos JC, Fernandes T, Roberto L et al (2015) Increased clearance of reactive aldehydes and damaged proteins in hypertension-induced compensated cardiac hypertrophy : impact of exercise training. Oxid Med Cell Longev 2015:1–11CrossRef

38.

Jordão C, Fernandes T, Tanaka L et al (2017) Aerobic swim training restores aortic endothelial function by decreasing superoxide levels in spontaneously hypertensive rats. Clinics 72:310–316. https://doi.org/10.6061/clinics/2017(05)09 CrossRefPubMedPubMedCentral

39.

Silva D, Jara ZP, Peres R et al (2017) Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension : role for local angiotensin II reduction. PLoS One 12:1–19

40.

Feairheller DL, Brown MD, Park J et al (2009) Exercise Training, NADPH oxidase p22phox gene polymorphisms, and hypertension. Med Sci Sports Exerc 41:1421–1428. https://doi.org/10.1249/MSS.0b013e318199cee8 CrossRefPubMedPubMedCentral

41.

Tsukiyama Y, Ito T, Nagaoka K et al (2017) Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes. J Clin Biochem Nutr 60:180–186. https://doi.org/10.3164/jcbn.16 CrossRefPubMedPubMedCentral

42.

Lamina S (2011) Comparative effects of interval and continuous training programs on serum uric acid in management of hypertension: a randomized controlled trial. J Strength Cond Res 25:719–726CrossRefPubMed

43.

Cook MD Heffernan, Ranadive KS, Woods JA, Fernhall B (2012) Effect of resistance training on biomarkers of vascular function and oxidative stress in young African-American and Caucasian men. J Hum Hypertens 27:388–392. https://doi.org/10.1038/jhh.2012.48 CrossRefPubMedPubMedCentral

44.

Fernandes F, Dantas O, Brasileiro-santos MS (2016) Effect of strength training on oxidative stress and the correlation of the same with forearm vasodilatation and blood pressure of hypertensive elderly women : a randomized clinical trial. PLoS One 11:1–19. https://doi.org/10.1371/journal.pone.0161178 CrossRef

45.

Patil SG, Dhanakshirur GB, Aithala MR et al (2014) Effect of yoga on oxidative stress in elderly with grade-i hypertension: a randomized controlled study. J Clin Diagn Res 8:4–7. https://doi.org/10.7860/JCDR/2014/9498.4586 CrossRef

46.

Yamamoto K, Kawano H, Gando Y et al (2009) Poor trunk flexibility is associated with arterial stiffening. Am J Physiol Heart Circ Physiol 297:H1314–H1318. https://doi.org/10.1152/ajpheart.00061.2009 CrossRefPubMed

47.

Gacitua T, Karachon L, Romero E et al (2017) Effects of resistance training on oxidative stress-related biomarkers in metabolic diseases: a review. Sport Sci Health. https://doi.org/10.1007/s11332-017-0402-5 CrossRef

48.

Keating SE, Machan E, O’Connor HT et al (2014) Continuous exercise but not high-intensity interval training improves fat distribution in overweight adults. J Obes 2014:834865. https://doi.org/10.1155/2014/834865 CrossRefPubMedPubMedCentral

49.

Cockcroft EJ, Williams CA, Tomlinson OW et al (2014) High-intensity interval exercise is an effective alternative to moderate intensity exercise for improving glucose tolerance and insulin sensitivity in adolescent boys. J Sci Med Sport 18:1–5. https://doi.org/10.1016/j.jsams.2014.10.001 CrossRef

50.

Sallam N, Laher I (2016) Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases. Oxid Med Cell Longev 2016:7239639. https://doi.org/10.1155/2016/7239639 CrossRefPubMed

51.

Merry TL, Ristow M (2015) Mitohormesis in exercise training. Free Radic Biol Med 98:123–130. https://doi.org/10.1016/j.freeradbiomed.2015.11.032 CrossRefPubMed

52.

Powers SK, Radak Z, Ji LL (2016) Exercise-induced oxidative stress: past, present and future. J Physiol. https://doi.org/10.1113/JP270646 CrossRefPubMedPubMedCentral

53.

Powers SK, Nelson WB, Hudson MB (2011) Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med 51:942–950. https://doi.org/10.1016/j.freeradbiomed.2010.12.009 CrossRefPubMed

54.

Bogdanis GC, Stavrinou P, Fatouros IG et al (2013) Short-term high-intensity interval exercise training attenuates oxidative stress responses and improves antioxidant status in healthy humans. Food Chem Toxicol 61:171–177. https://doi.org/10.1016/j.fct.2013.05.046 CrossRefPubMed

55.

Powers SK, Jackson MJ (2008) Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 88:1243–1276. https://doi.org/10.1152/physrev.00031.2007 CrossRefPubMed

56.

Henríquez-Olguín C, Díaz-Vegas A, Utreras-Mendoza Y et al (2016) NOX2 inhibition impairs early muscle gene expression induced by a single exercise bout. Front Physiol 7:1–12. https://doi.org/10.3389/fphys.2016.00282 CrossRef

57.

Díaz-Vegas A, Campos CA, Contreras-ferrat A et al (2015) ROS production via P2Y1-PKC-NOX2 is triggered by extracellular ATP after electrical stimulation of skeletal muscle cells ROS Production via P2Y 1 -PKC-NOX2 is triggered by extracellular atp after electrical stimulation of skeletal muscle cells. PLoS One. https://doi.org/10.1371/journal.pone.0129882 CrossRefPubMedPubMedCentral

58.

Baldelli S, Aquilano K, Ciriolo MR (2013) Punctum on two different transcription factors regulated by PGC-1α: nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2. BBA Gen Subj 1830:4137–4146. https://doi.org/10.1016/j.bbagen.2013.04.006 CrossRef

59.

Irrcher I, Ljubicic V, Hood DA (2008) Interactions between ROS and AMP kinase activity in the regulation of PGC-1a transcription in skeletal muscle cells. Am J Physiol Cell Physiol 3:116–123. https://doi.org/10.1152/ajpcell.00267.2007 CrossRef

60.

Ros E, Shock H, Dimauro I et al (2016) Exercise-induced ROS in Heat Shock Proteins response. Free Radic Biol Med 98:46–55. https://doi.org/10.1016/j.freeradbiomed.2016.03.028 CrossRef

61.

Madamanchi Nageswara Li, Patterson Suzhen, Cam Runge M (2001) Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway. Arterioscler Thromb Vasc Biol 21:321–326. https://doi.org/10.1161/01.ATV.21.3.321 CrossRefPubMed

62.

Esposito F, Ronchi R, Milano G, Margonato V (2011) Myocardial tolerance to ischemia-reperfusion injury, training intensity and cessation. Eur J Appl Physiol 111:859–868. https://doi.org/10.1007/s00421-010-1707-0 CrossRefPubMed

63.

Merry TL, Ristow M (2016) Nuclear factor erythroid-derived 2-like2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice. J Physiol 18:5195–5207. https://doi.org/10.1113/JP271957 CrossRef

64.

Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1–15. https://doi.org/10.1002/jcp.10119 CrossRefPubMed

65.

Goodwin BL, Pendleton LC, Levy MM et al (2007) Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells. Am J Physiol Circ Physiol 33612:1115–1121. https://doi.org/10.1152/ajpheart.01100.2006 CrossRef

Titel: Effects of physical exercise on oxidative stress biomarkers in hypertensive animals and non-diabetic subjects with prehypertension/hypertension: a review
verfasst von: F. Vicencio
P. Jiménez
F. Huerta
C. Cofré-Bolados
S. Gutiérrez Zamorano
D. F. Garcia-Diaz
R. Rodrigo
C. Poblete-Aro
Publikationsdatum: 10.07.2019
Verlag: Springer Milan
Erschienen in: Sport Sciences for Health / Ausgabe 3/2019
Print ISSN: 1824-7490
Elektronische ISSN: 1825-1234
DOI: https://doi.org/10.1007/s11332-019-00561-1

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen.
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

25.04.2024 | Hypertonie | Nachrichten

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Effects of physical exercise on oxidative stress biomarkers in hypertensive animals and non-diabetic subjects with prehypertension/hypertension: a review

Abstract

Background

Methodology

Results

Conclusions

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Update Orthopädie und Unfallchirurgie

Springer Medizin

Abstract

Background

Methodology

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2019

The influence of environment potentiality (affordances) on motor development in 6–9 years old children with intellectual disability

The effect of physical exercise on anxiety among the victims of child abuse

Mountain biker attitudes and perceptions of eMTBs (electric-mountain bikes)

Performance-associated parameters of players from the deaf Czech Republic national soccer team: a comparison with hearing first league players

Plasma retinol-binding protein-4 and tumor necrosis factor-α are reduced in postmenopausal women after combination of different intensities of circuit resistance training and Zataria supplementation

A combined plyometric and resistance training program improves fitness performance in 12 to 14-years-old boys

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Ärztliche Empathie hilft gegen Rückenschmerzen

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Update Orthopädie und Unfallchirurgie