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Endocrine
Erschienen in: Endocrine 3/2015

01.12.2015 | Original Article

Effects of soy phytoestrogens on pituitary-ovarian function in middle-aged female rats

verfasst von: Ivana M. Medigović, Jasmina B. Živanović, Vladimir Z. Ajdžanović, Aleksandra L. Nikolić-Kokić, Sanja D. Stanković, Svetlana L. Trifunović, Verica Lj. Milošević, Nataša M. Nestorović

Erschienen in: Endocrine | Ausgabe 3/2015

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Abstract

The aim of this study was to assess the effects of genistein (G) and daidzein (D) on the histological, hormonal, and functional parameters of the pituitary-ovarian axis in middle-aged female rats, and to compare these effects with the effects of estradiol (E), commonly used in the prevention and treatment of menopausal symptoms. Middle-aged (12 month old) Wistar female rats subcutaneously received 35 mg/kg of G, or 35 mg/kg of D, or 0.625 mg/kg of E every day for 4 weeks. Each of the treated groups had a corresponding control group. An intact control group was also established. G and D did not change the intracellular protein content within gonadotropic and lactotropic cells, but vacuolization was observed in all the cell types. In contrast, E caused an inhibition of gonadotropic and stimulation of lactotropic cells. Also, ovaries of middle-aged female rats exposed to G or D have more healthy primordial and primary follicles and less atretic follicles. E treatment in the ovaries had a mostly negative effect, which is reflected by the increased number of atretic follicles in all tested classes. G and D provoked decrease in CuZnSOD and CAT activity, while E treatment increased MnSOD and decreased CuZnSOD and GSHPx activity. All the treatments increased serum estradiol and decreased testosterone levels, while D and E increased the serum progesterone level. In conclusion, soy phytoestrogens exhibited beneficial effects on pituitary-ovarian function in middle-aged female rats, as compared to estradiol.
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Metadaten
Titel
Effects of soy phytoestrogens on pituitary-ovarian function in middle-aged female rats
verfasst von
Ivana M. Medigović
Jasmina B. Živanović
Vladimir Z. Ajdžanović
Aleksandra L. Nikolić-Kokić
Sanja D. Stanković
Svetlana L. Trifunović
Verica Lj. Milošević
Nataša M. Nestorović
Publikationsdatum
01.12.2015
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2015
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-015-0691-x

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