nach oben

Erschienen in:

06.03.2023 | Original Article

Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome

verfasst von: Kosar Namakin, Meysam Hassani Moghaddam, Sara Sadeghzadeh, Maryam Mehranpour, Kimia Vakili, Mobina Fathi, Ahmadreza Golshan, Amir-Hossein Bayat, Amir-Hossein Tajik, Neda Eskandari, Ibrahim Mohammadzadeh, Soheila Zamanlui Benisi, Abbas Aliaghaei, Mohammad-Amin Abdollahifar

Erschienen in: Metabolic Brain Disease | Ausgabe 5/2023

Einloggen, um Zugang zu erhalten

Abstract

Irritable bowel syndrome (IBS) is related to a problem in the gut-brain axis. This experimental research aimed to shed light on the potential therapeutic application of elderberry (EB), which can work on the axis and get better the IBS symptoms. There were three groups (36 Sprague-Dawley rats) in this experiment, including control, IBS, and IBS with EB diet (IBS + EB). Making use of intracolonic instillation of 1 ml of 4% acetic acid for 30 s, IBS was induced. 7 days later, the EB extract (2%) was added to the diets of all animals for 8 weeks. Some histological, behavioral, and stereological techniques were used to detect the effects of EB on the gut and brain tissues. The findings showed that the EB diet improved locomotion and decreased anxiety-like behavior in the rat models of IBS. Moreover, the diet dropped the expression of TNF-α and increased mucosal layer thickness and the number of goblet and mast cells in colon tissue samples. In the hippocampal samples, administration of EB prevented astrogliosis and astrocyte reactivity. Although hippocampal and cortical neurons decreased markedly in the IBS group, EB prevented the drop in the number of neurons. Although lots of research is needed to elucidate the effectiveness of EB in IBS and its exact molecular mechanism, the result of this study showed that EB as an antioxidant and immune-modulatory agent could be a promising research target to prevent the impairment in the gut-brain axis, and could ameliorative classic IBS symptoms.

Amaral F, Sachs D, Costa V, Fagundes C, Cisalpino D, Cunha T, Ferreira S, Cunha F, Silva T, Nicoli J (2008) Commensal microbiota is fundamental for the development of inflammatory pain. Proc Natl Acad Sci U S A 105:2193–2197. https://doi.org/10.1073/pnas.0711891105CrossRefPubMedPubMedCentral

Anjaneyulu M, Chopra K, Kaur I (2003) Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice. J Med Food 6:391–395. https://doi.org/10.1089/109662003772519976CrossRefPubMed

Badescu M, Badulescu O, Badescu L, Ciocoiu M (2015) Effects of Sambucus nigra and Aronia melanocarpa extracts on immune system disorders within diabetes mellitus. Pharm Biol 53:533–539. https://doi.org/10.3109/13880209.2014.931441CrossRefPubMed

Balestra B, Vicini R, Cremon C, Zecchi L, Dothel G, Vasina V, De Giorgio R, Paccapelo A, Pastoris O, Stanghellini V (2012) Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons. Neurogastroenterol Motil 24:1118-e1570. https://doi.org/10.1111/nmo.12000CrossRefPubMed

Barak V, Halperin T, Kalickman I (2001) The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 12:290–296PubMed

Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126:693–702. https://doi.org/10.1053/j.gastro.2003.11.055CrossRefPubMed

Barbara G, Wang B, Stanghellini V, De Giorgio R, Cremon C, Di Nardo G, Trevisani M, Campi B, Geppetti P, Tonini M (2007) Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 132:26–37. https://doi.org/10.1053/j.gastro.2006.11.039CrossRefPubMed

Bercik P, Collins S, Verdu E (2012) Microbes and the gut-brain axis. Neurogastroenterol Motil 24:405–413. https://doi.org/10.1111/j.1365-2982.2012.01906.xCrossRefPubMed

Berer K, Mues M, Koutrolos M, Rasbi ZA, Boziki M, Johner C, Wekerle H, Krishnamoorthy G (2011) Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479:538–541. https://doi.org/10.1038/nature10554CrossRefPubMed

Bischoff SC, Krämer S (2007) Human mast cells, bacteria, and intestinal immunity. Immunol Rev 217:329–337. https://doi.org/10.1111/j.1600-065x.2007.00523.xCrossRefPubMed

Boroujeni ME, Simani L, Bluyssen HA, Samadikhah HR, Zamanlui Benisi S, Hassani S, Akbari Dilmaghani N, Fathi M, Vakili K, Mahmoudiasl G-R (2021) Inflammatory response leads to neuronal death in human post-mortem cerebral cortex in patients with COVID-19. ACS Chem Neurosci. https://doi.org/10.1021/acschemneuro.1c00111CrossRefPubMed

Buhner S, Li Q, Vignali S, Barbara G, De Giorgio R, Stanghellini V, Cremon C, Zeller F, Langer R, Daniel H (2009) Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology 137:1425–1434. https://doi.org/10.1053/j.gastro.2009.07.005CrossRefPubMed

Bundy R, Walker AF, Middleton RW, Booth J (2004) Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J Altern Complement Med 10:1015–1018. https://doi.org/10.1089/acm.2004.10.1015CrossRefPubMed

Butt AS, Salih M, Jafri W, Yakoob J, Wasay M, Hamid S (2012) Irritable bowel syndrome and psychiatric disorders in Pakistan: a case control study. Gastroenterol Res Pract 2012. https://doi.org/10.1155/2012/291452

Camilleri M (2013) Current and future pharmacological treatments for diarrhea-predominant irritable bowel syndrome. Expert Opin Pharmacother 14:1151–1160. https://doi.org/10.1517/14656566.2013.794223CrossRefPubMed

Camilleri M, McKinzie S, Busciglio I, Low PA, Sweetser S, Burton D, Baxter K, Ryks M, Zinsmeister AR (2008) Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 6:772–781. https://doi.org/10.1016/j.cgh.2008.02.060CrossRefPubMedPubMedCentral

Cattaneo A, Cattane N, Galluzzi S, Provasi S, Lopizzo N, Festari C, Ferrari C, Guerra UP, Paghera B, Muscio C (2017) Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol Aging 49:60–68. https://doi.org/10.1016/j.neurobiolaging.2016.08.019CrossRefPubMed

Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett NW (2007) Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest 117:636–647. https://doi.org/10.1172/jci29255CrossRefPubMedPubMedCentral

Chen P-C, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Kan YW, Johnson JA (2009) Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson’s disease: critical role for the astrocyte. Proc Natl Acad Sci U S A 106:2933–2938. https://doi.org/10.1073/pnas.0813361106CrossRefPubMedPubMedCentral

Chitkara DK, van Tilburg MA, Blois-Martin N, Whitehead WE (2008) Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review. Am J Gastroenterol 103. https://doi.org/10.1111/j.1572-0241.2007.01722.x

Cremon C, Carini G, Wang B, Vasina V, Cogliandro RF, De Giorgio R, Stanghellini V, Grundy D, Tonini M, De Ponti F (2011) Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol 106:1290–1298. https://doi.org/10.1038/ajg.2011.86CrossRefPubMed

Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13:701–712. https://doi.org/10.1038/nrn3346CrossRefPubMed

Davis BM, Salinas-Navarro M, Cordeiro MF, Moons L, De Groef L (2017) Characterizing microglia activation: a spatial statistics approach to maximize information extraction. Sci Rep 7:1–12. https://doi.org/10.1038/s41598-017-01747-8CrossRef

de Rus Jacquet A, Timmers M, Ma SY, Thieme A, McCabe GP, Vest JHC, Lila MA, Rochet J-C (2017) Lumbee traditional medicine: neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptoms. J Ethnopharmacol 206:408–425. https://doi.org/10.1016/j.jep.2017.02.021CrossRefPubMedPubMedCentral

de Vries HE, Witte M, Hondius D, Rozemuller AJ, Drukarch B, Hoozemans J, van Horssen J (2008) Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med 45:1375–1383. https://doi.org/10.1016/j.freeradbiomed.2008.09.001CrossRefPubMed

Drossman DA (2006) The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130:1377–1390. https://doi.org/10.1053/j.gastro.2006.03.008

Farzaneh N, Ghobakhlou M, Moghimi-Dehkordi B, Naderi N, Fadai F (2012) Evaluation of psychological aspects among subtypes of irritable bowel syndrome. Indian J Psychol Med 34:144–148. https://doi.org/10.4103/0253-7176.101780CrossRefPubMedPubMedCentral

Ferreira SS, Martins-Gomes C, Nunes FM, Silva AM (2022) Elderberry (Sambucus nigra L.) extracts promote anti-inflammatory and cellular antioxidant activity. Food Chem: X 15:100437PubMed

Fond G, Loundou A, Hamdani N, Boukouaci W, Dargel A, Oliveira J, Roger M, Tamouza R, Leboyer M, Boyer L (2014) Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci 264:651–660. https://doi.org/10.1007/s00406-014-0502-zCrossRefPubMed

Gan L, Vargas MR, Johnson DA, Johnson JA (2012) Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model. J Neurosci 32:17775–17787. https://doi.org/10.1523/jneurosci.3049-12.2012CrossRefPubMedPubMedCentral

Giannini EG, Mansi C, Dulbecco P, Savarino V (2006) Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome. Nutrition 22:334–342. https://doi.org/10.1016/j.nut.2005.10.003CrossRefPubMed

Gray AM, Abdel-Wahab YH, Flatt PR (2000) The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. J Nutr 130:15–20. https://doi.org/10.1093/jn/130.1.15CrossRefPubMed

Guilarte M, Santos J, De Torres I, Alonso C, Vicario M, Ramos L, Martínez C, Casellas F, Saperas E, Malagelada JR (2007) Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 56:203–209. https://doi.org/10.1136/gut.2006.100594CrossRefPubMed

Guven B, Can M, Piskin O, Aydin BG, Karakaya K, Elmas O, Acikgoz B (2019) Flavonoids protect colon against radiation induced colitis. Regul Toxicol Pharmacol 104:128–132. https://doi.org/10.1016/j.yrtph.2019.03.006CrossRefPubMed

Gyoneva S, Davalos D, Biswas D, Swanger SA, Garnier-Amblard E, Loth F, Akassoglou K, Traynelis SF (2014) Systemic inflammation regulates microglial responses to tissue damage in vivo. Glia 62:1345–1360. https://doi.org/10.1002/glia.22686CrossRefPubMedPubMedCentral

Hawrelak JA, Myers SP (2010) Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 16:1065–1071. https://doi.org/10.1089/acm.2009.0090CrossRefPubMed

Héron A, Dubayle D (2013) A focus on mast cells and pain. J Neuroimmunol 264:1–7. https://doi.org/10.1016/j.jneuroim.2013.09.018CrossRefPubMed

Jang H, Ha U-S, Kim S-J, Yoon B-I, Han D-S, Yuk S-M, Kim S-W (2010) Anthocyanin extracted from black soybean reduces prostate weight and promotes apoptosis in the prostatic hyperplasia-induced rat model. J Agric Food Chem 58:12686–12691CrossRefPubMed

Kennedy P, Cryan J, Quigley E, Dinan T, Clarke G (2014) A sustained hypothalamic–pituitary–adrenal axis response to acute psychosocial stress in irritable bowel syndrome. Psychol Med 44:3123–3134. https://doi.org/10.1017/s003329171400052xCrossRefPubMed

Kennedy PJ, Clarke G, Quigley EM, Groeger JA, Dinan TG, Cryan JF (2012) Gut memories: towards a cognitive neurobiology of irritable bowel syndrome. Neurosci Biobehav Rev 36:310–340. https://doi.org/10.1016/j.neubiorev.2011.07.001CrossRefPubMed

Kilpatrick LA, Gupta A, Love AD, Labus JS, Alaverdyan M, Tillisch K, Naliboff BD, Mayer EA (2015) Mo2030 neurobiology of psychological resilience in Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) patients. Gastroenterology 148:S-774. https://doi.org/10.1016/S0016-5085%2815%2932639-1

Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, van der Heide S, Schemann M, Bischoff SC, van den Wijngaard RM, Boeckxstaens GE (2010) The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut 59:1213–1221. https://doi.org/10.1136/gut.2010.213108CrossRefPubMed

Klooker TK, Braak B, Painter RC, De Rooij SR, Van Elburg RM, Van Den Wijngaard RM, Roseboom TJ, Boeckxstaens GE (2009) Exposure to severe wartime conditions in early life is associated with an increased risk of irritable bowel syndrome: a population-based cohort study. Am J Gastroenterol 104:2250–2256. https://doi.org/10.1038/ajg.2009.282CrossRefPubMed

Knowles SR, Austin DW, Sivanesan S, Tye-Din J, Leung C, Wilson J, Castle D, Kamm MA, Macrae F, Hebbard G (2017) Relations between symptom severity, illness perceptions, visceral sensitivity, coping strategies and well-being in irritable bowel syndrome guided by the common sense model of illness. Psychol Health Med 22:524–534. https://doi.org/10.1080/13548506.2016.1168932CrossRefPubMed

Krammer L, Sowa AS, Lorentz A (2019) Mast cells in irritable bowel syndrome: a systematic review. J Gastrointest Liver Dis 28. https://doi.org/10.15403/jgld-229

Kumar H, Kim I-S, More SV, Kim B-W, Choi D-K (2014) Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases. Nat Prod Rep 31:109–139. https://doi.org/10.1039/c3np70065hCrossRefPubMed

Kumar H, Koppula S, Kim I-S, Vasant More S, Kim B-W, Choi D-K (2012) Nuclear factor erythroid 2-related factor 2 signaling in Parkinson disease: a promising multi therapeutic target against oxidative stress, neuroinflammation and cell death. CNS Neurol Disord Drug Targets 11:1015–1029. https://doi.org/10.2174/1871527311211080012CrossRefPubMed

Lamy S, Muhire É, Annabi B (2018) Antiproliferative efficacy of elderberries and elderflowers (Sambucus canadensis) on glioma and brain endothelial cells under normoxic and hypoxic conditions. J Funct Foods 40:164–179CrossRef

Langhammer CG, Previtera ML, Sweet ES, Sran SS, Chen M, Firestein BL (2010) Automated Sholl analysis of digitized neuronal morphology at multiple scales: whole cell Sholl analysis versus Sholl analysis of arbor subregions. Cytometry Part A 77:1160–1168. https://doi.org/10.1002/cyto.a.20954CrossRef

Levy RL, Olden KW, Naliboff BD, Bradley LA, Francisconi C, Drossman DA, Creed F (2006) Psychosocial aspects of the functional gastrointestinal disorders. Gastroenterology 130:1447–1458. https://doi.org/10.1016/s0889-8553(05)70363-0CrossRefPubMed

Liu JP, Yang M, Liu Y, Wei ML, Grimsgaard S (2006) Herbal medicines for treatment of irritable bowel syndrome. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.cd004116.pub2CrossRefPubMedPubMedCentral

López-Gómez L, Bagüés A, Uranga JA, Abalo R (2020) Preclinical models of irritable bowel syndrome. A comprehensive overview of irritable bowel syndrome. Elsevier, 233–276

Mahmoudi M, Ebrahimzadeh M, Dooshan A, Arimi A, Ghasemi N, Fathiazad F (2014) Antidepressant activities of Sambucus ebulus and Sambucus nigra. Eur Rev Med Pharmacol Sci 18:3350–3353PubMed

Manocha GD, Floden AM, Miller NM, Smith AJ, Nagamoto-Combs K, Saito T, Saido TC, Combs CK (2019) Temporal progression of Alzheimer’s disease in brains and intestines of transgenic mice. Neurobiol Aging 81:166–176. https://doi.org/10.1016/j.neurobiolaging.2019.05.025CrossRefPubMedPubMedCentral

Mao Y (2016) Nearest neighbor distances calculation with ImageJ. Journal

Martin CR, Osadchiy V, Kalani A, Mayer EA (2018) The brain-gut-microbiome axis. Cell Mol Gastroenterol Hepatol 6:133–148CrossRefPubMedPubMedCentral

Mayer EA (2011) Gut feelings: the emerging biology of gut–brain communication. Nat Rev Neurosci 12:453–466. https://doi.org/10.1038/nrn3071CrossRefPubMed

Mayer EA, Naliboff BD, Chang L, Coutinho SV (2001) Stress and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 280:G519-G524. https://doi.org/10.1152/ajpgi.2001.280.4.g519

Mikulic-Petkovsek M, Ivancic A, Todorovic B, Veberic R, Stampar F (2015) Fruit phenolic composition of different elderberry species and hybrids. J Food Sci 80:C2180–C2190. https://doi.org/10.1111/1750-3841.13008CrossRefPubMed

Moghaddam MH, Bayat A-H, Eskandari N, Abdollahifar M-a, Fotouhi F, Forouzannia A, Rafiei R, Hatari S, Seraj A, Shahidi AMEJ (2021) Elderberry diet ameliorates motor function and prevents oxidative stress-induced cell death in rat models of Huntington disease. Brain Res 1762:147444. https://doi.org/10.1016/j.brainres.2021.147444CrossRefPubMed

Moghaddam MH, Farrokhi S, Hasani A, Khosravi A, Pirani M, Vakili K, Fathi M, Eskandari N, Golshan A, Sadeghzadeh S, Namakin K, Aliaghaei A, Abdollahifar M-A (2022) Elderberry diet restores spermatogenesis in the transient Scrotal Hyperthermia-Induced mice. Reprod Sci 29:3373–3386. https://doi.org/10.1007/s43032-022-00865-7CrossRefPubMed

Moloney RD, Johnson AC, O’mahony SM, Dinan TG, Greenwood-Van Meerveld B, Cryan JF (2016) Stress and the microbiota–gut–brain axis in visceral pain: relevance to irritable bowel syndrome. CNS Neurosci Ther 22:102–117. https://doi.org/10.1111/cns.12490CrossRefPubMed

Moser G, Fournier C, Peter J (2018) Intestinal microbiome-gut-brain axis and irritable bowel syndrome. Wien Med Wochenschr 168:62–66. https://doi.org/10.1007/s10354-017-0592-0CrossRefPubMed

Mota AH, Duarte N, Serra AT, Ferreira A, Bronze MR, Custódio L, Gaspar MM, Simões S, Rijo P, Ascensão L (2020) Further evidence of possible therapeutic uses of Sambucus nigra L. extracts by the assessment of the in vitro and in vivo anti-inflammatory properties of its PLGA and PCL-based nanoformulations. Pharmaceutics 12:1181. https://doi.org/10.3390/pharmaceutics12121181CrossRefPubMedPubMedCentral

Muscatello MRA, Bruno A, Pandolfo G, Mico U, Stilo S, Scaffidi M, Consolo P, Tortora A, Pallio S, Giacobbe G (2010) Depression, anxiety and anger in subtypes of irritable bowel syndrome patients. J Clin Psychol Med Settings 17:64–70. https://doi.org/10.1007/s10880-009-9182-7CrossRefPubMed

Netzel M, Strass G, Herbst M, Dietrich H, Bitsch R, Bitsch I, Frank T (2005) The excretion and biological antioxidant activity of elderberry antioxidants in healthy humans. Food Res Int 38:905–910. https://doi.org/10.1016/j.foodres.2005.03.010CrossRef

O’sullivan M, Clayton N, Breslin N, Harman I, Bountra C, McLaren A, O’Morain C (2000) Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Motil 12:449–458. https://doi.org/10.1046/j.1365-2982.2000.00221.xCrossRefPubMed

Öhman L, Simrén M (2010) Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions. Nat Rev Gastroenterol Hepatol 7:163–173. https://doi.org/10.1038/nrgastro.2010.4CrossRefPubMed

Park A, Collins J, Blennerhassett P, Ghia J, Verdu E, Bercik P, Collins S (2013) Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol Motil 25:733-e575. https://doi.org/10.1111/nmo.12153CrossRefPubMedPubMedCentral

Peery AF, Dellon ES, Lund J, Crockett SD, McGowan CE, Bulsiewicz WJ, Gangarosa LM, Thiny MT, Stizenberg K, Morgan DR (2012) Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology 143:1179–1187. https://doi.org/10.1053/j.gastro.2012.08.002CrossRefPubMed

Pellissier S, Dantzer C, Mondillon L, Trocme C, Gauchez A-S, Ducros V, Mathieu N, Toussaint B, Fournier A, Canini F (2014) Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn’s disease and irritable bowel syndrome. PLoS ONE 9:e105328. https://doi.org/10.1371/journal.pone.0105328CrossRefPubMedPubMedCentral

Portincasa P, Bonfrate L, Scribano ML, Kohn A, Caporaso N, Festi D, Campanale MC, Di Rienzo T, Guarino M, Taddia M (2016) Curcumin and fennel essential oil improve symptoms and quality of life in patients with irritable bowel syndrome. J Gastrointest Liver Dis 25. https://doi.org/10.15403/jgld.2014.1121.252.ccm

Raskov H, Burcharth J, Pommergaard H-C, Rosenberg J (2016) Irritable bowel syndrome, the microbiota and the gut-brain axis. Gut microbes 7:365–383CrossRefPubMedPubMedCentral

Rhee SH, Pothoulakis C, Mayer EA (2009) Principles and clinical implications of the brain–gut–enteric microbiota axis. Nat Rev Gastroenterol Hepatol 6:306–314. https://doi.org/10.1038/nrgastro.2009.35CrossRefPubMed

Rugină D, Hanganu D, Diaconeasa Z, Tăbăran F, Coman C, Leopold L, Bunea A, Pintea A (2017) Antiproliferative and apoptotic potential of cyanidin-based anthocyanins on melanoma cells. Int J Mol Sci 18:949CrossRefPubMedPubMedCentral

Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V (2016) Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell 167:1469–1480. https://doi.org/10.1016/j.cell.2016.11.018CrossRefPubMedPubMedCentral

Santos J, Guilarte M, Alonso C, Malagelada J (2005) Pathogenesis of irritable bowel syndrome: the mast cell connection. Scand J Gastroenterol 40:129–140. https://doi.org/10.1080/00365520410009410CrossRefPubMed

Satoh T, McKercher SR, Lipton SA (2013) Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med 65:645–657. https://doi.org/10.1016/j.freeradbiomed.2013.07.022CrossRefPubMed

Semar S, Klotz M, Letiembre M, Van Ginneken C, Braun A, Jost V, Bischof M, Lammers WJ, Liu Y, Fassbender K (2013) Changes of the enteric nervous system in amyloid-β protein precursor transgenic mice correlate with disease progression. J Alzheimers Dis 36:7–20. https://doi.org/10.3233/jad-120511CrossRefPubMed

Shen H, Guan Q, Zhang X, Yuan C, Tan Z, Zhai L, Hao Y, Gu Y, Han C (2020) New mechanism of neuroinflammation in Alzheimer’s disease: the activation of NLRP3 inflammasome mediated by gut microbiota. Prog Neuropsychopharmacol Biol Psychiatry 100:109884. https://doi.org/10.1016/j.pnpbp.2020.109884CrossRefPubMed

Shih AY, Johnson DA, Wong G, Kraft AD, Jiang L, Erb H, Johnson JA, Murphy TH (2003) Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J Neurosci 23:3394–3406. https://doi.org/10.1523/jneurosci.23-08-03394.2003CrossRefPubMedPubMedCentral

Shukla PK, Delotterie DF, Xiao J, Pierre JF, Rao R, McDonald MP, Khan MM (2021) Alterations in the gut-microbial-inflammasome-brain axis in a mouse model of Alzheimer’s disease. Cells 10:779. https://doi.org/10.3390/cells10040779CrossRefPubMedPubMedCentral

Spanier JA, Howden CW, Jones MP (2003) A systematic review of alternative therapies in the irritable bowel syndrome. Arch Intern Med 163:265–274. https://doi.org/10.1001/archinte.163.3.265CrossRefPubMed

Stanculete MF, Matu S, Pojoga C, Dumitrascu DL (2015) Coping strategies and irrational beliefs as mediators of the health-related quality of life impairments in irritable bowel syndrome. J Gastrointest Liver Dis 24. https://doi.org/10.15403/jgld.2014.1121.242.strt

Stasi C, Rosselli M, Bellini M, Laffi G, Milani S (2012) Altered neuro-endocrine–immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model. J Gastroenterol 47:1177–1185. https://doi.org/10.1007/s00535-012-0627-7CrossRefPubMed

Sugaya N, Nomura S, Shimada H (2012) Relationship between cognitive factors and anxiety in individuals with irritable bowel syndrome. Int J Behav Med 19:308–315. https://doi.org/10.1007/s12529-011-9195-0CrossRefPubMed

Tang QL, Lai ML, Zhong YF, Wang AM, Su JK, Zhang MQ (2013) Antinociceptive effect of berberine on visceral hypersensitivity in rats. World J Gastroenterol 19:4582–4589. https://doi.org/10.3748/wjg.v19.i28.4582CrossRefPubMedPubMedCentral

Tejera D, Mercan D, Sanchez-Caro JM, Hanan M, Greenberg D, Soreq H, Latz E, Golenbock D, Heneka MT (2019) Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome. EMBO J 38:e101064. https://doi.org/10.15252/embj.2018101064CrossRefPubMedPubMedCentral

Tiralongo E, Wee SS, Lea RA (2016) Elderberry supplementation reduces cold duration and symptoms in air-travellers: a randomized, double-blind placebo-controlled clinical trial. Nutrients 8:182. https://doi.org/10.3390/nu8040182CrossRefPubMedPubMedCentral

Uranga JA, Martínez V, Abalo R (2020) Mast cell regulation and irritable bowel syndrome: Effects of food components with potential nutraceutical use. Molecules 25:4314. https://doi.org/10.3390/molecules25184314CrossRefPubMedPubMedCentral

Valdez-Morales EE, Overington J, Guerrero-Alba R, Ochoa-Cortes F, Ibeakanma CO, Spreadbury I, Bunnett NW, Beyak M, Vanner SJ (2013) Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2. Am J Gastroenterol 108:1634–1643. https://doi.org/10.1038/ajg.2013.241CrossRefPubMed

van Tilburg MA, Runyan DK, Zolotor AJ, Graham JC, Dubowitz H, Litrownik AJ, Flaherty E, Chitkara DK, Whitehead WE (2010) Unexplained gastrointestinal symptoms after abuse in a prospective study of children at risk for abuse and neglect. Ann Fam Med 8:134–140. https://doi.org/10.1370/afm.1053CrossRefPubMedPubMedCentral

Varian BJ, Goureshetti S, Poutahidis T, Lakritz JR, Levkovich T, Kwok C, Teliousis K, Ibrahim YM, Mirabal S, Erdman SE (2016) Beneficial bacteria inhibit cachexia. Oncotarget 7:11803CrossRefPubMedPubMedCentral

Vuong HE, Hsiao EY (2017) Emerging roles for the gut microbiome in autism spectrum disorder. Biol Psychiatry 81:411–423. https://doi.org/10.1016/j.biopsych.2016.08.024CrossRefPubMed

Wang S, Tanzi RE, Li A (2019) Quantitative analysis of neuronal dendritic arborization complexity in Drosophila. JoVE. https://doi.org/10.3791/57139CrossRefPubMed

Wäussle H, Grüunert U, Röhrenbeck J (1993) Immunocytochemical staining of AII-amacrine cells in the rat retina with antibodies against parvalbumin. J Comp Neurol 332:407–420. https://doi.org/10.1002/cne.903320403CrossRef

Wesolowski J, Paumet F (2011) The impact of bacterial infection on mast cell degranulation. Immunol Res 51:215–226. https://doi.org/10.1007/s12026-011-8250-xCrossRefPubMed

Wood H (2018) Peripheral inflammation could be a prodromal indicator of dementia. Nat Rev Neurol 14:127–127. https://doi.org/10.1038/nrneurol.2018.8CrossRefPubMed

Xu L, Yu W, Jiang J, Feng X, Li N (2015) Efficacy of pectin in the treatment of diarrhea predominant irritable bowel syndrome. Zhonghua wei Chang wai ke za zhi = Chinese. J Gastrointest Surg 18:267–271. https://doi.org/10.3760/CMA.J.ISSN.1671-0274.2015.03.015CrossRef

Zhang J, Wen C, Zhang H, Duan Y (2019) Review of isolation, structural properties, chain conformation, and bioactivities of psyllium polysaccharides. Int J Biol Macromol 139:409–420. https://doi.org/10.1016/j.ijbiomac.2019.08.014CrossRefPubMed

Zhang L, Song J, Hou X (2016) Mast cells and irritable bowel syndrome: from the bench to the bedside. J Neurogastroenterol Motil 22:181. https://doi.org/10.5056/jnm15137CrossRefPubMedPubMedCentral

Titel: Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome
verfasst von: Kosar Namakin
Meysam Hassani Moghaddam
Sara Sadeghzadeh
Maryam Mehranpour
Kimia Vakili
Mobina Fathi
Ahmadreza Golshan
Amir-Hossein Bayat
Amir-Hossein Tajik
Neda Eskandari
Ibrahim Mohammadzadeh
Soheila Zamanlui Benisi
Abbas Aliaghaei
Mohammad-Amin Abdollahifar
Publikationsdatum: 06.03.2023
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 5/2023
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-023-01187-6

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Vierten reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Bluttest erkennt Parkinson schon zehn Jahre vor der Diagnose

10.05.2024 Parkinson-Krankheit Nachrichten

Ein Bluttest kann abnorm aggregiertes Alpha-Synuclein bei einigen Menschen schon zehn Jahre vor Beginn der motorischen Parkinsonsymptome nachweisen. Mit einem solchen Test lassen sich möglicherweise Prodromalstadien erfassen und die Betroffenen früher behandeln.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Wartezeit nicht kürzer, aber Arbeit flexibler

Psychotherapie Medizin aktuell

Fünf Jahren nach der Neugestaltung der Psychotherapie-Richtlinie wurden jetzt die Effekte der vorgenommenen Änderungen ausgewertet. Das Hauptziel der Novellierung war eine kürzere Wartezeit auf Therapieplätze. Dieses Ziel wurde nicht erreicht, es gab jedoch positive Auswirkungen auf andere Bereiche.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2023

Correction to: Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model

Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy

Irisin attenuates ethanol-induced behavioral deficits in mice through activation of Nrf2 and inhibition of NF-κB pathways

The role of brain inflammation and abnormal brain oxygen homeostasis in the development of hepatic encephalopathy

Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson’s disease induced by reserpine