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Journal of Assisted Reproduction and Genetics

Erschienen in:

01.03.2014 | Assisted Reproduction Technologies

Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF

verfasst von: D. S. Berger, A. Zapantis, Z. Merhi, J. Younger, A. J. Polotsky, S. K. Jindal

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 3/2014

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Abstract

Purpose

The association between pronuclear (PN) scoring of embryos from assisted reproductive technology (ART) and clinical pregnancy remains controversial. We hypothesized that embryos with PNs scored on the day of fertilization check offer better embryo selection on day 3 and higher CPR compared to non-PN scored embryos.

Methods

Patients (19–46 years) undergoing IVF/ICSI cycles at Montefiore’s Institute for Reproductive Medicine and Health between January 2006 and December 2009 were included in our study. We analyzed fresh day 3 cycles only with autologous oocytes and partner’s fresh sperm (n = 344). A total of 1,899 embryos were included. We compared CPR from non-PN scored embryos (Group 1, n = 835) with PN scored embryos (Group 2, n = 1,064). Composite scores by patient were developed based on embryo disposition. We also assessed traditional embryo grading derived from cell number, fragmentation and cell symmetry. Data analysis included chi square and t test to determine if PN scoring was associated with improved CPR, and to compare the additional variables.

Results

CPR between Group 1 and Group 2 were not different (p = 0.91). CPR was significantly associated with female age, number of mature oocytes retrieved, number of day 3 embryos and grade of embryos transferred on day 3 (p < 0.05).

Conclusion

PN scoring was not associated with improved CPR in day 3 embryo transfers. Mean grade of transferred embryos continues to be a well-established, independent predictor of CPR. We conclude that further refinement of embryo grading by PN scoring is not beneficial.

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Titel: Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF
verfasst von: D. S. Berger
A. Zapantis
Z. Merhi
J. Younger
A. J. Polotsky
S. K. Jindal
Publikationsdatum: 01.03.2014
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 3/2014
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-0162-3

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