nach oben

Journal of Assisted Reproduction and Genetics

Erschienen in:

01.03.2014 | Assisted Reproduction Technologies

Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?

verfasst von: Keliang Wu, Haibin Zhao, Hui Liu, Mei Li, Shuiying Ma, Cheng Li, Chang Liu, Zi-Jiang Chen

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 3/2014

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To compare the clinical outcomes after day 3 embryo transfer, day 5 single blastocyst transfer (SBT) and frozen-thawed embryo transfer (FET) in high responder patients (>15 retrieved oocytes) undergoing IVF/ICSI treatment.

Methods

A retrospective analysis of three embryo transfer strategies for the high responder patients in IVF/ICSI cycles. The 1041 high responder patients diagnosed as primary infertility with more than 15 oocytes retrieved were recruited in Day 3 ET group, 308 patients with more than 15 oocytes retrieved first transferred with one blastocyst in SBT group and 425 patients with more than 15 oocytes retrieved in fresh cycle, first transferred with one frozen-thawed blastocyst were assigned in FET group.

Results

In the high responder patients, the clinical pregnancy rate after day 5 SBT was significantly lower than that of day 3 ET (43.18 % VS 57.16 %, p < 0.05). In addition, the clinical pregnant rate and implantation rate of FET cycles were significantly higher than SBT cycles (59.06 % vs. 43.18 % and 64.70 % vs. 47.40 %, p < 0.05). The multiple pregnancy rate in FET cycles was markedly lower than that of day 3 ET (2.35 % VS 34.97 %, p < 0.05).

Conclusions

FET was the preferable strategy for the high responder patients in IVF/ICSI cycles to obtain both desirable clinical outcome and lower multiple pregnancy rates.

Alexander GR, Kogan M, Martin J, Papiernik E. What are the fetal growth patterns of singletons, twins, and triplets in the United States? Clin Obstet Gynecol. 1998;41:114–25.PubMedCrossRef

Alexander GR, Slay WM, Salihu H, Kirby RS. Fetal and neonatal mortality risks of multiple births. Obstet Gynecol Clin North Am. 2005;32:1–16.PubMedCrossRef

Blondel B, Kogan MD, Alexander GR, Dattani N, Kramer MS, Macfarlane A, et al. The impact of the increasing number of multiple births on the rates of preterm birth and low birthweight: an international study. Am J Public Health. 2002;92:1323–30.PubMedCentralPubMedCrossRef

Bergh C. Single embryo transfer: a mini-review. Hum Reprod. 2005;20:323–7.PubMedCrossRef

Bryan E. The impact of multiple preterm births on the family. BJOG. 2003;110 Suppl 20:24–8.PubMedCrossRef

Simon C, Juna JG, Valbuena D, Peinado J, Pellicer A. Increasing uterine receptivity by decreasing estradiol levels during the preimplantation period in high responderers with the use of a follicle-stimulating hormone step-down regimen. Fertil Steril. 1998;70:234–9.PubMedCrossRef

Criniti A, Thyer A, Chow G, Lin P, Klein N, Soules M. Elective single blastocyst transfer reduces twin rates without compromising pregnancy rates. Fertil Steril. 2005;84:1613–9.PubMedCrossRef

Stoop D, Van Landuyt L, Camus M, Pevroey P. Should a single blastocyst transfer policy be a clinical decision or should it depend on the embryological evaluation on day 3? Reprod Bio and Endo. 2011;9:60–8.CrossRef

Ellison MA, Hall JE. Social stigma and compounded losses: quality-of-life issues for multiple-birth families. Fertil Steril. 2003;80:405–14.PubMedCrossRef

10.

Ellison MA, Hotamisligil S, Lee H, Rich-Edwards JW, Pang SC, Hall JE. Psychosocial risks associated with multiple births resulting from assisted reproduction. Fertil Steril. 2005;83:1422–8.PubMedCrossRef

11.

Gardner DK, Lane M. Culture and selection of viable blastocysts: a feasible proposition for human IVF? Hum Reprod Update. 1997;3:367–82.PubMedCrossRef

12.

Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril. 2000;73:1155–8.PubMedCrossRef

13.

Glazebrook C, Sheard C, Cox S, Oates M, Ndukwe G. Parenting stress in first-time mothers of twins and triplets conceived after in vitro fertilization. Fertil Steril. 2004;81:505–11.PubMedCrossRef

14.

Gunby J, Daya S. Assisted reproductive technologies (ART) in Canada:2001 results from the Canadian ART Register. Fertil Steril. 2005;84:590–9.PubMedCrossRef

15.

McWhinnie A. Euphoria or despair? Coping with multiple births from ART: what patients don’t tell the clinics. Hum Fertil (Camb). 2000;3:20–5.PubMedCrossRef

16.

National Center for Chronic Disease Prevention and Health Promotion, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. 2001 Assisted reproductive technology success rates: national summary and fertility clinic reports. Atlanta: Centers for Disease Control and Prevention, December 2003.

17.

Olivennes F, Golombok S, Ramogida C, Rust J. Behavioral and cognitive development as well as family functioning of twins conceived by assisted reproduction: findings from a large population study. Fertil Steril. 2005;84:725–33.PubMedCrossRef

18.

Papanikolaou E, Kolibianakis E, Tournaye H, Venetis C, Fatemi H, Tarlatzis B, et al. Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and metaanalysis. Hum Reprod. 2008;23:91–9.PubMedCrossRef

19.

Papanikolaou E, Camus M, Kolibianakis E, Van Landuyt L, Van Steirteghem A, Devroey P. In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. N Engl J Med. 2006;354:1139–46.PubMedCrossRef

20.

Pinborg A, Loft A, Schmidt L, Andersen AN. Morbidity in a Danish national cohort of 472 IVF/ICSI twins, 1132 non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their families. Hum Reprod. 2003;18:1234–43.PubMedCrossRef

21.

Paulson RJ, Sauer MV, Lobo RA. Embryo implantation after human in vitro fertilization: importance of endometrial receptivity. Fertil Steril. 1990;53:870–4.PubMed

22.

Puissant F, Van Ryssellberge M, Barlow P. Embryo scoring as a prognostic tool in IVF treatment. Hum Reprod. 1987;2:705–8.PubMed

23.

Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responderers. Fertil Steril. 2011;96(2):344–8.PubMedCrossRef

24.

Valbuena D, Martin J, de Pablo JL, Remohi J, Pellicer A, Simon C. Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo. Fertil Steril. 2001;76:962–8.PubMedCrossRef

25.

Wright VC, Schieve LA, Reynolds MA, Jeng G. Assisted reproductive technology surveillance—United States, 2002. MMWR Surveill Summ. 2005;54:1–24.PubMed

Titel: Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?
verfasst von: Keliang Wu
Haibin Zhao
Hui Liu
Mei Li
Shuiying Ma
Cheng Li
Chang Liu
Zi-Jiang Chen
Publikationsdatum: 01.03.2014
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 3/2014
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-0156-1

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Welche Übungen helfen gegen Diastase recti abdominis?

30.04.2024 Schwangerenvorsorge Nachrichten

Die Autorinnen und Autoren einer aktuellen Studie aus Griechenland sind sich einig, dass Bewegungstherapie, einschließlich Übungen zur Stärkung der Bauchmuskulatur und zur Stabilisierung des Rumpfes, eine Diastase recti abdominis postpartum wirksam reduzieren kann. Doch vieles ist noch nicht eindeutig belegt.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?