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01.09.2011 | Original Article

Epidemiological and clinical characteristics of pediatric gastroenteritis associated with new viral agents

verfasst von: Sara Giordana Rimoldi, Fabrizio Stefani, Cristina Pagani, Lisa Lucia Chenal, Nadia Zanchetta, Ilaria Di Bartolo, Alessandra Lombardi, Franco Maria Ruggeri, Dario Di lillo, Gian Vincenzo Zuccotti, Maria Rita Gismondo

Erschienen in: Archives of Virology | Ausgabe 9/2011

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Abstract

A 22-month study (2008-2009) was carried out on 273 patients (average age 40 months), admitted with gastroenteritis to the Pediatric Unit of L. Sacco University Hospital in Milan, Italy. Fecal samples were investigated for rotavirus (HRV), norovirus (NoV), adenovirus (AdV), sapovirus (SaV), enterovirus, astrovirus and bocavirus (HBoV). A 38.3% incidence of infection was observed for HRV, followed by NoV (16.2%), HBoV (13.6%), AdV (2.6%) and SaV (0.6%). Clinical evaluation of 109 gastroenteritis patients with confirmed diagnosis was graded by the Ruska-Vesikari scoring system, showing vomiting (78%), diarrhea (96%) and fever (80%). A total of 25 NoV-positive samples were selected for nucleotide sequence analysis. The severity of AdV-associated infection was lower than for NoV, HRV and HBoV. These latter viruses caused similar symptoms that were indistinguishable using clinical information. NoV, HRV and HBoV were often present as mixed infections (13.1%). Sequencing of NoV-positive samples allowed identification of GII.2, GII.3 and GII.4 2006 variants.

Colomba C, Saporito L, Giammanco GM, De Grazia S, Ramirez S, Arista S, Titone L (2007) Norovirus and gastroenteritis in hospitalized children, Italy. Emerg Infect Dis 9:1389–1391

Medici MC, Martinelli M, Abelli LA, Ruggeri FM, Di Bartolo I, Arcangeletti MC, Pinardi F, De Conto F, Izzi G, Bernasconi S, Chezzi C, Dettori G (2006) Molecular epidemiology of norovirus infections in sporadic cases of viral gastroenteritis among children in northern Italy. J Med Virol 78:1486–1492PubMedCrossRef

Medici MC, Martinelli M, Arcangeletti MC, Pinardi F, De Conto F, Dodi I, Virdis R, Abelli LA, Aloisi A, Zerbini L, Valcavi P, Calderaro A, Bernasconi S, Izzi GC, Dettori G, Chezzi C (2004) Epidemiological aspects of human rotavirus infection in children hospitalized with acute gastroenteritis in an area of northern of Italy. Acta Biomed 75:100–106PubMed

Iritani N, Seto Y, Kubo H, Murakami T, Haruki K, Ayata M, Ogura H (2003) Prevalence of Norwalk like virus infection in cases of viral gastroenteritis among children in Osaka City, Japan. J Clin Microbiol 41:1756–1759PubMedCrossRef

Hansman G, Saito H, Shibata C, Oseto M, Oka T, Taeda N (2007) Outbreaks of gastroenteritis due to sapovirus. JCM 45:1347–1349

Allander T (2008) Human bocavirus. J Clin Virol 41:29–33PubMedCrossRef

De Grazia S, Giammanco GM, Colomba C, Cascio A, Arista S (2004) Molecular epidemiology of astrovirus infection in Italian children with gastroenteritis. Clin Microbiol Infect 10:1006–1035CrossRef

Ruggeri FM, Declich S (1999) Rotavirus infection among children with diarrhoea in Italy. Acta Pediatr Suppl 88(426):66–71CrossRef

Ruska T, Versikari T (1990) Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes. Scand J Infect Dis 22:259–267CrossRef

10.

Rockx B, de Wit M, Vennema H, Vinjé J, de Bruin E, van Duynhoven Y, Koopmans M (2002) Natural history of human calicivirus infection: a prospective cohort study. Clin Inf Dis 35:246–253CrossRef

11.

Farka T, Zhong WM, Jing Y, Huang PW, Espinosa SM, Martinez N, Morrow AL, Ruiz-Palacios GM, Pickering LK, Jiang X (2004) Genetic diversity among sapovirus. Arch Virol 149:1309–1323

12.

Hansman GS, Katayama K, Maneekarn N, Peerakome S, Khamrin P, Tonusin S, Okitsu S, Nishio O, Takeda N, Ushijima H (2004) Genetic diversity of Norovirus and Sapovirus in hospitalized infants with sporadic cases of acute gastroenteritis in Chiang Mai, Thailand. JCM 42(3):1305–1307

13.

Kojima S, Kageyama T, Fukushi S, Hoshino FB, Shinohara M, Uchida K, Natori K, Takeda N, Katayama K (2002) Genogroup-specific PCR primers for detection of Norwalk-like viruses. J Virol Methods 100:107–114PubMedCrossRef

14.

Lopman BA, Reacher MH, Vipond IB, Hill D, Perry C, Halladay T, Brown DW, Edmunds WJ, Sarangi J (2004) Epidemiology and cost of nosocomial gastroenteritis Avon England 2002–2003. Emerg Infect Dis 10:1827–1834PubMed

15.

Moreno-Espinosa S, Farkas T, Jiang X (2004) Human caliciviruses and pediatric gastroenteritis. Semin Pediatric Infect Dis 15:237–245CrossRef

16.

McIver CJ, Hansman G, White P, Doultree JC, Catton M, Rawlinson WD (2001) Diagnosis of enteric pathogens in children with gastroenteritis. Pathology 33:353–358PubMed

17.

Bereciartu A, Bok K, Gómez J (2002) Identification of viral agents causing gastroenteritis among children in Buenos Aires, Argentina. J Clin Microbiol 25:197–200

18.

Dennehy PH, Heartin M, Nelson SM, Reising SF (1999) Evaluation of the ImmunoCardSTAT! Rotavirus assay for detection of group A rotavirus in fecal specimens. J Clin Microbiol 37:1977–1979PubMed

19.

De Grazia S, Ramirez S, Giammanco GM, Colomba C, Martella V, Lo Biundo C, Mazzola R, Arista S (2007) Diversity of human rotaviruses detected in Sicily, Italy, over a 5-year period (2001–2005). Arch Virol 152:833–837PubMedCrossRef

20.

Colomba C, Saporito L, Giammanco GM, De Grazia S, Ramirez S, Arista S, Titone L (2007) Norovirus and gastroenteritis in hospitalized children, Italy. Emerg Infect Dis 9:1389–1391

21.

22.

Chiba S, Sakuma Y, Kogasaka R, Akihara M, Horino K, Nakao T, Fukui S (1979) An outbreak of gastroenteritis associated with calicivirus in an infant home. J Med Virol 4:249–254PubMedCrossRef

23.

Cunliffe NA, Booth JA, Elliot C, Lowe SJ, Sopwith W, Kitchin N, Nakagomi O, Nakagomi T, Hart CA, Regan M (2010) Health-care associated viral gastroenteritis among children in a large pediatric hospital, United Kingdom. Emerg Infect Dis 16(1):55–62PubMedCrossRef

24.

Simpson R, Aliyu S, Iturriza-Gómara M, Desselberger U, Gray J (2003) Infantile viral gastroenteritis: on the way to closing the diagnostic gap. J Med Virol 70(2):258–256

25.

Esposito S, Bosis S, Niesters HG, Tremolati E, Sabatini C, Porta A, Fossali E, Osterhaus AD, Principi N (2008) Impact of human bocavirus on children and their families. J Clin Microbiol 46:1337–1342PubMedCrossRef

26.

Yu JM, Li DD, Xu ZQ, Cheng WX, Zhang Q, Li HY, Cui SX, Miao-Jin Yang SH, Fang ZY, Duan ZJ (2008) Human bocavirus infection in children hospitalized with acute gastroenteritis in China. J Clin Virol 42(3):280–285PubMedCrossRef

27.

Lindell AT, Grillner L, Svensson L, Wirgart BZ (2005) Molecular epidemiology of norovirus infection in Stockholm, Sweden, during the year 2000 to 2003: association of the GGIIb genetic cluster with infection in children. J Clin Microbiol 43:1086–1092PubMedCrossRef

28.

Greninger AL, Runchel C, Chiu CY, Haggerty T, Parsonnet J, Ganem D, De Risi JL (2009) The complete genome of Klassevirus—a novel picornavirus in pediatric stool. Virol J 6:1–9CrossRef

29.

Arthur JL, Higgins GD, Davidson GP, Givney RC, Ratcliff R (2009) A novel bocavirus associated with acute gastroenteritis in Australian children. PLoS Pathog 5(4):e1000391PubMedCrossRef

30.

Pham NT, Trin QD, Khamrin P, Maneekarnn N, Shimizu H, Okitsu S, Mizuguchi M, Ushijima H (2009) Diversity of human parechoviruses isolated in stool samples collected from Thai children with acute gastroenteritis. J Clin Microbiol 48(1):115–119PubMedCrossRef

Titel: Epidemiological and clinical characteristics of pediatric gastroenteritis associated with new viral agents
verfasst von: Sara Giordana Rimoldi
Fabrizio Stefani
Cristina Pagani
Lisa Lucia Chenal
Nadia Zanchetta
Ilaria Di Bartolo
Alessandra Lombardi
Franco Maria Ruggeri
Dario Di lillo
Gian Vincenzo Zuccotti
Maria Rita Gismondo
Publikationsdatum: 01.09.2011
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 9/2011
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-011-1037-5

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