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Current Heart Failure Reports

Erschienen in:

19.08.2020 | Translational Research in Heart Failure (J Backs & M van den Hoogenhof, Section Editors)

Epitranscriptomics in the Heart: a Focus on m⁶A

verfasst von: Jacob Z. Longenecker, Christopher J. Gilbert, Volha A. Golubeva, Colton R. Martens, Federica Accornero

Erschienen in: Current Heart Failure Reports | Ausgabe 5/2020

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Abstract

Purpose of Review

Post-transcriptional modifications are key regulators of gene expression that allow the cell to respond to environmental stimuli. The most abundant internal mRNA modification is N6-methyladenosine (m⁶A), which has been shown to be involved in the regulation of RNA splicing, localization, translation, and decay. It has also been implicated in a wide range of diseases, and here, we review recent evidence of m⁶A’s involvement in cardiac pathologies and processes.

Recent Findings

Studies have primarily relied on gain and loss of function models for the enzymes responsible for adding and removing the m⁶A modification. Results have revealed a multifaceted role for m⁶A in the heart’s response to myocardial infarction, pressure overload, and ischemia/reperfusion injuries. Genome-wide analyses of mRNAs that are differentially methylated during cardiac stress have highlighted the importance of m⁶A in regulating the translation of specific categories of transcripts implicated in pathways such as calcium handling, cell growth, autophagy, and adrenergic signaling in cardiomyocytes.

Summary

Regulation of gene expression by m⁶A is critical for cardiomyocyte homeostasis and stress responses, suggesting a key role for this modification in cardiac pathophysiology.

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Titel: Epitranscriptomics in the Heart: a Focus on m6A
verfasst von: Jacob Z. Longenecker
Christopher J. Gilbert
Volha A. Golubeva
Colton R. Martens
Federica Accornero
Publikationsdatum: 19.08.2020
Verlag: Springer US
Erschienen in: Current Heart Failure Reports / Ausgabe 5/2020
Print ISSN: 1546-9530
Elektronische ISSN: 1546-9549
DOI: https://doi.org/10.1007/s11897-020-00473-z

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Epitranscriptomics in the Heart: a Focus on m⁶A