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08.06.2020 | Review Article

Epstein–Barr virus-associated gastric cancer: disease that requires special approach

verfasst von: Ekaterina Ignatova, Daria Seriak, Mikhail Fedyanin, Alexey Tryakin, Ilya Pokataev, Sofia Menshikova, Yuliya Vakhabova, Ksenia Smirnova, Sergey Tjulandin, Jaffer A. Ajani

Erschienen in: Gastric Cancer | Ausgabe 6/2020

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Abstract

Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV( +) GC also has a unique epigenetic profile and mutational status with frequent mutations of PIK3CA, ARID1A and BCOR, and PD-L1 and PD-L2 amplifications, as well. The aim of this review is to highlight clinical significance of EBV( +) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.

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Titel: Epstein–Barr virus-associated gastric cancer: disease that requires special approach
verfasst von: Ekaterina Ignatova
Daria Seriak
Mikhail Fedyanin
Alexey Tryakin
Ilya Pokataev
Sofia Menshikova
Yuliya Vakhabova
Ksenia Smirnova
Sergey Tjulandin
Jaffer A. Ajani
Publikationsdatum: 08.06.2020
Verlag: Springer Singapore
Erschienen in: Gastric Cancer / Ausgabe 6/2020
Print ISSN: 1436-3291
Elektronische ISSN: 1436-3305
DOI: https://doi.org/10.1007/s10120-020-01095-z

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Weitere Artikel der Ausgabe 6/2020

LncRNA HOTAIR promotes the growth and metastasis of gastric cancer by sponging miR-1277-5p and upregulating COL5A1

Optimal extent of lymph node dissection for remnant advanced gastric carcinoma after distal gastrectomy: a retrospective analysis of more than 3000 patients from the nationwide registry of the Japanese Gastric Cancer Association

Metformin use reduced the risk of stomach cancer in diabetic patients in Korea: an analysis of Korean NHIS-HEALS database

Effect of Helicobacter pylori eradication after subtotal gastrectomy on the survival rate of patients with gastric cancer: follow-up for up to 15 years

Development and validation of a deep learning system for ascites cytopathology interpretation

Endoscopic three-categorical diagnosis of Helicobacter pylori infection using linked color imaging and deep learning: a single-center prospective study (with video)

Update Chirurgie