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Cardiovascular Toxicology

Erschienen in:

02.05.2020

RETRACTED ARTICLE: Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity

verfasst von: Qifei Xie, Suiji Li, Yun Gao, Ling Jin, Cuilian Dai, Juan Song

Erschienen in: Cardiovascular Toxicology | Ausgabe 5/2020

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Abstract

Phytomedicine has shown a promising potential for the prevention of cardiovascular system diseases and disorders. This study aimed to evaluate protective effect of ergosterol (ER) on isoproterenol (ISO)-induced myocardial cardiotoxicity. We found that pretreatment with ER significantly decreased levels of myocardial CK-MB and LDH, and alleviated myocardial damage induced by ISO in rat model. In addition, ER restored Nrf2 and HO-1 expression and inhibited apoptosis through upregulating Bcl-2 and downregulating Bax, cytochrome c, cleaved caspase-3, caspase-9, and PARP in rat hearts. Hypoxia-reoxygenation model in H9C2 cells confirmed the cardioprotective effects of ER. In conclusion, we provide both in vitro and in vivo evidence that ER significantly enhances Nrf2-mediated anti-oxidative activities, and exerts a protective effect on cardiomyocyte apoptosis. ER could be considered as a potential therapeutic agent to prevent myocardial injury.

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Titel: RETRACTED ARTICLE: Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity
verfasst von: Qifei Xie
Suiji Li
Yun Gao
Ling Jin
Cuilian Dai
Juan Song
Publikationsdatum: 02.05.2020
Verlag: Springer US
Erschienen in: Cardiovascular Toxicology / Ausgabe 5/2020
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-020-09574-6

Springer Medizin

Abstract

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