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Competing interests
AW is an employee of Bristol-Myers Squibb which produces dasatinib and BMS911543. The remaining authors declare that they have no competing interests.
Authors’ contributions
FMJ conceived and designed the project, supervised all the experiments, and wrote the manuscript. SP, BS, and TM helped to design and performed all the animal and bench experiments. CJC and YZ performed the gene expression analysis and prepared the corresponding figures. JM, DB, MDW, and SYL assisted with the study design and tissue acquisition, critically reviewed the data, and reviewed the manuscript. Additionally MDW performed all the histologic tissue analyses including interpretation of the IHC and prepared the corresponding figures. AW and ML were involved with the pre-clinical development of BMS-911543 and assisted with the study design and preparation of the manuscript. All authors gave final approval of the manuscript.