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Erschienen in: Digestive Diseases and Sciences 12/2006

01.12.2006 | Original Article

Esophageal Impedance/pH Monitoring in Pediatric Patients: Preliminary Experience with 50 Cases

verfasst von: Girolamo Mattioli, Alessio Pini-Prato, Valerio Gentilino, Enrica Caponcelli, Stefano Avanzini, Stefano Parodi, Giovanni A. Rossi, Pietro Tuo, Paolo Gandullia, Claudio Vella, Vincenzo Jasonni

Erschienen in: Digestive Diseases and Sciences | Ausgabe 12/2006

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Abstract

This paper describes multiple intraluminal impedance (MII) in 50 children with typical and atypical gastroesophageal reflux (GER) symptoms and discusses the possible clinical significance of objective numeric data provided by MII computed analysis. Patients underwent 24-hr pH/MII monitoring. Reflux parameters were analyzed with relation to age and reported symptoms. Nonacidic MII events occurred as frequently as acidic ones. A Pathologic Bolus Exposure Index associated with a normal pH Reflux Index was detected in 26% of our series. Significant correlations were found regarding acid and bolus clearing times and their ratio.
We conclude that the low rate of symptom occurrence in the pediatric population represents a limit on MII evaluation. Our study confirmed that nonacid GER is at least as frequent as acid GER. As MII provides interesting objective data that could be used in clinical practice, we suggest further research to define normal ranges in the pediatric population.
Literatur
1.
Zurück zum Zitat Poets CF (2004) Gastroesophageal reflux: a critical review of its role in preterm infants. Pediatrics 113:128–132CrossRef Poets CF (2004) Gastroesophageal reflux: a critical review of its role in preterm infants. Pediatrics 113:128–132CrossRef
2.
Zurück zum Zitat Gold BD (2003) Outcomes of pediatric Gastroesophageal reflux disease: in the first year of life, in childhood, and in adults … oh, and should we really leave Helicobacter pylori alone? J Pediatr Gastroenterol Nutr 37:S33–S39CrossRefPubMed Gold BD (2003) Outcomes of pediatric Gastroesophageal reflux disease: in the first year of life, in childhood, and in adults … oh, and should we really leave Helicobacter pylori alone? J Pediatr Gastroenterol Nutr 37:S33–S39CrossRefPubMed
3.
Zurück zum Zitat Kim J, Keininger DL, Becker S, Crawley JA (2005) Simultaneous development of the pediatric GERD Caregiver Impact Questionnaire (PGCIQ) in American English and American Spanish. Health Qual Life Outcomes 14;3(1):5CrossRef Kim J, Keininger DL, Becker S, Crawley JA (2005) Simultaneous development of the pediatric GERD Caregiver Impact Questionnaire (PGCIQ) in American English and American Spanish. Health Qual Life Outcomes 14;3(1):5CrossRef
4.
Zurück zum Zitat Mattioli G, Sacco O, Repetto P, Pini Prato A, Castagnetti M, Carlini C, Torre M, Leggio S, Gentilino V, Martino F, Fregonese B, Barabino A, Gandullia P, Rossi GA, Jasonni V (2004) Necessity for surgery in children with gastrooesophageal reflux and supraoesophageal symptoms. Eur J Pediatr Surg 14(1):7–13CrossRefPubMed Mattioli G, Sacco O, Repetto P, Pini Prato A, Castagnetti M, Carlini C, Torre M, Leggio S, Gentilino V, Martino F, Fregonese B, Barabino A, Gandullia P, Rossi GA, Jasonni V (2004) Necessity for surgery in children with gastrooesophageal reflux and supraoesophageal symptoms. Eur J Pediatr Surg 14(1):7–13CrossRefPubMed
5.
Zurück zum Zitat Wenzl TG, Silny J, Schenke S, Peschgens T, Heimann G, Skopnik H (1999) Gastroesophageal reflux and respiratory phenomena in infants: status of the intraluminal impedance technique. J Pediatr Gastroenterol Nutr 28:423–428CrossRefPubMed Wenzl TG, Silny J, Schenke S, Peschgens T, Heimann G, Skopnik H (1999) Gastroesophageal reflux and respiratory phenomena in infants: status of the intraluminal impedance technique. J Pediatr Gastroenterol Nutr 28:423–428CrossRefPubMed
6.
Zurück zum Zitat Vandenplas Y, Belli D, Boige N (1992) A standardised protocol for the methodology of esophageal pH monitoring and interpretation of the data for the diagnosis of gastroesophageal reflux. Statement of the European Society of Pediatric Gastroenterology and Nutrition (ESPGAN). J Pediatr Gastroenterol Nutr 14:467–471 Vandenplas Y, Belli D, Boige N (1992) A standardised protocol for the methodology of esophageal pH monitoring and interpretation of the data for the diagnosis of gastroesophageal reflux. Statement of the European Society of Pediatric Gastroenterology and Nutrition (ESPGAN). J Pediatr Gastroenterol Nutr 14:467–471
7.
Zurück zum Zitat Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Colletti RB, Gerson WT, Werlin SL (2001) Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society of Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr 32(Suppl 2):S1–S31CrossRefPubMed Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Colletti RB, Gerson WT, Werlin SL (2001) Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society of Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr 32(Suppl 2):S1–S31CrossRefPubMed
8.
Zurück zum Zitat Mitchell DJ, McClure BG, Tubman TR (2001) Simultaneous monitoring of gastric and esophageal pH reveals limitations of conventional oesophageal pH monitoring in milk fed infants. Arch Dis Child 84:273–276CrossRefPubMed Mitchell DJ, McClure BG, Tubman TR (2001) Simultaneous monitoring of gastric and esophageal pH reveals limitations of conventional oesophageal pH monitoring in milk fed infants. Arch Dis Child 84:273–276CrossRefPubMed
9.
Zurück zum Zitat Fass R, Achem SR, Harding S, Mittal RK, Quigley E (2004) Review article: supraesophageal manifestations of gastroesophageal reflux disease and the role of night-time gastroesophageal reflux. Aliment Pharmacol Ther 20(S9):26–38CrossRefPubMed Fass R, Achem SR, Harding S, Mittal RK, Quigley E (2004) Review article: supraesophageal manifestations of gastroesophageal reflux disease and the role of night-time gastroesophageal reflux. Aliment Pharmacol Ther 20(S9):26–38CrossRefPubMed
10.
Zurück zum Zitat Wenzl TG (2002) Investigating esophageal reflux with the intraluminal impendance technique. J Pediatr Gastroenterol Nutr 43:261–268 Wenzl TG (2002) Investigating esophageal reflux with the intraluminal impendance technique. J Pediatr Gastroenterol Nutr 43:261–268
11.
Zurück zum Zitat Wenzl TG, Schenke S, Peschjens T, Silny J, Heimann G, Skopnik H (2001) Association of apnoea and non-acid gastroesophageal reflux in infants: investigations with the intraluminal impedance technique. Pediatr Pulmonol 31:144–149CrossRefPubMed Wenzl TG, Schenke S, Peschjens T, Silny J, Heimann G, Skopnik H (2001) Association of apnoea and non-acid gastroesophageal reflux in infants: investigations with the intraluminal impedance technique. Pediatr Pulmonol 31:144–149CrossRefPubMed
12.
Zurück zum Zitat Colletti RB, Christie DL, Orenstein SR (1995) Statement of the North American Society for Pediatric Gastroenterology and Nutrition (NASPGN). Indications for pediatric esophageal pH monitoring. J Pediatr Gastroenterol Nutr 21(3):253–262PubMedCrossRef Colletti RB, Christie DL, Orenstein SR (1995) Statement of the North American Society for Pediatric Gastroenterology and Nutrition (NASPGN). Indications for pediatric esophageal pH monitoring. J Pediatr Gastroenterol Nutr 21(3):253–262PubMedCrossRef
13.
Zurück zum Zitat Hegar B, Vandemaele K, Arana A, Vandenplas Y (2000) Esophageal pH monitoring in infants: elimination of gastric buffering does not modify reflux index. J Gastroenterol Hepatol 15(8):902–905CrossRefPubMed Hegar B, Vandemaele K, Arana A, Vandenplas Y (2000) Esophageal pH monitoring in infants: elimination of gastric buffering does not modify reflux index. J Gastroenterol Hepatol 15(8):902–905CrossRefPubMed
14.
Zurück zum Zitat Wenzl TG (2003) Evaluation of gastroesophageal reflux events in children using multichannel intraluminal electrical impedance. Am J Med 115(3A):161S–165SCrossRefPubMed Wenzl TG (2003) Evaluation of gastroesophageal reflux events in children using multichannel intraluminal electrical impedance. Am J Med 115(3A):161S–165SCrossRefPubMed
15.
Zurück zum Zitat Silny J (1991) Intraluminal multiple electric impedance procedure for measurement of gastrointestinal motility. J Gastrointest Motil 3:151–162CrossRef Silny J (1991) Intraluminal multiple electric impedance procedure for measurement of gastrointestinal motility. J Gastrointest Motil 3:151–162CrossRef
16.
Zurück zum Zitat Shay S, Tutuian R, Sifrim D, Vela M, Wise J, Balaji N, Zhang X, Adhami T, Murray J, Peters J, Castell D (2004) Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from sixty healthy volunteers. Am J Gastroenterol 99(6):1037–1043CrossRefPubMed Shay S, Tutuian R, Sifrim D, Vela M, Wise J, Balaji N, Zhang X, Adhami T, Murray J, Peters J, Castell D (2004) Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from sixty healthy volunteers. Am J Gastroenterol 99(6):1037–1043CrossRefPubMed
17.
Zurück zum Zitat Johnson LF, De Meester TR (1974) Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol 62:325–332PubMed Johnson LF, De Meester TR (1974) Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol 62:325–332PubMed
18.
Zurück zum Zitat Bagucka B, Badriul H, Vandemaele K, Troch E, Vandenplas Y (2000) Normal ranges of continuous pH monitoring in the proximal esophagus. J Pediatr Gastroenterol Nutr 31(3):244–247CrossRefPubMed Bagucka B, Badriul H, Vandemaele K, Troch E, Vandenplas Y (2000) Normal ranges of continuous pH monitoring in the proximal esophagus. J Pediatr Gastroenterol Nutr 31(3):244–247CrossRefPubMed
19.
Zurück zum Zitat Tutian R, Castell D (2005) Multichannel intraluminal impedance: general principles and technical issues. Gastrointest Endosc Clin N Am 15(2):257–264CrossRef Tutian R, Castell D (2005) Multichannel intraluminal impedance: general principles and technical issues. Gastrointest Endosc Clin N Am 15(2):257–264CrossRef
20.
Zurück zum Zitat National Institute of Health (1987) Consensus Development Conference on infantile apnea and home monitoring. Sept 29 to Oct 1, 1986. Consensus statement. Pediatrics 79:292–299 National Institute of Health (1987) Consensus Development Conference on infantile apnea and home monitoring. Sept 29 to Oct 1, 1986. Consensus statement. Pediatrics 79:292–299
21.
Zurück zum Zitat Seigel DG, Podgor MJ, Remaley NA (1992) Acceptable value of kappa for comparison of two groups. Am J Epidemiol 135(5):571–578PubMed Seigel DG, Podgor MJ, Remaley NA (1992) Acceptable value of kappa for comparison of two groups. Am J Epidemiol 135(5):571–578PubMed
22.
Zurück zum Zitat Sacco O, Fregonese B, Silvestri M (2000) Bronchoalveolar lavage and esophageal pH monitoring data in children with “difficult to treat” respiratory symptoms. Pediatr Pulmonol. 4:313–319CrossRef Sacco O, Fregonese B, Silvestri M (2000) Bronchoalveolar lavage and esophageal pH monitoring data in children with “difficult to treat” respiratory symptoms. Pediatr Pulmonol. 4:313–319CrossRef
23.
Zurück zum Zitat Sifirm D, Dupont L, Blondeau K, Zhang X, Tack J, Janssens J (2005) Weakly acidic reflux in patients with chronic unexplained cough during 24 hours pressure, pH, and impedance monitoring. Gut 54:449–454CrossRef Sifirm D, Dupont L, Blondeau K, Zhang X, Tack J, Janssens J (2005) Weakly acidic reflux in patients with chronic unexplained cough during 24 hours pressure, pH, and impedance monitoring. Gut 54:449–454CrossRef
Metadaten
Titel
Esophageal Impedance/pH Monitoring in Pediatric Patients: Preliminary Experience with 50 Cases
verfasst von
Girolamo Mattioli
Alessio Pini-Prato
Valerio Gentilino
Enrica Caponcelli
Stefano Avanzini
Stefano Parodi
Giovanni A. Rossi
Pietro Tuo
Paolo Gandullia
Claudio Vella
Vincenzo Jasonni
Publikationsdatum
01.12.2006
Erschienen in
Digestive Diseases and Sciences / Ausgabe 12/2006
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-006-9374-z

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