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Journal of Neural Transmission

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01.11.2012 | Neurology and Preclinical Neurological Studies - CONy Pro/Con debate

Essential tremor: is it a neurodegenerative disease? No

verfasst von: Monica M. Kurtis

Erschienen in: Journal of Neural Transmission | Ausgabe 11/2012

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Abstract

In the past decade, many advances have been made regarding clinical characteristics, neurophysiology, imaging, pathology and genetics of essential tremor, the most common of movement disorders. The first part of this article summarizes available data in these fields, with emphasis on recent reports. In the discussion, the reported data supporting the view that essential tremor is a neurodegenerative disease is critically reviewed and this hypothesis is challenged. Finally, an alternative pathophysiological explanation based on the generation of central oscillating pacemakers is put forth. This hypothesis allows for different causes of essential tremor and therefore explains the existing heterogeneity of clinical manifestations and therapeutic response.

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Titel: Essential tremor: is it a neurodegenerative disease? No
verfasst von: Monica M. Kurtis
Publikationsdatum: 01.11.2012
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 11/2012
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-012-0875-y

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