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01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BMC Infectious Diseases 1/2018

Estimating the scale of chronic hepatitis B virus infection among migrants in EU/EEA countries

Zeitschrift:
BMC Infectious Diseases > Ausgabe 1/2018
Autoren:
Amena A. Ahmad, Abby M. Falla, Erika Duffell, Teymur Noori, Angela Bechini, Ralf Reintjes, Irene K. Veldhuijzen
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12879-017-2921-8) contains supplementary material, which is available to authorized users.

Abstract

Background

Chronic hepatitis B (CHB) related morbidity and mortality can be reduced through risk group screening, linkage to care and anti-viral treatment. This study estimates the number of CHB cases among foreign-born (migrants) in the European Union and European Economic Area (EU/EEA) countries in order to identify the most affected migrant populations.

Methods

The CHB burden was estimated by combining: demographic data on migrant population size by country of birth in the EU/EEA, extracted from European statistical databases; and CHB prevalence in migrants’ countries of birth and in EU/EEA countries, derived from a systematic literature search. The relative contribution of migrants from endemic countries to the total CHB burden in each country was also estimated. The reliability of using country of birth prevalence as a proxy for prevalence among migrants was assessed by comparing it to the prevalence found in studies among migrants in Europe.

Results

An estimated 1–1.9 million CHB-infected migrants from endemic countries (prevalence ≥2%) reside in the EU/EEA. Migrants from endemic countries comprise 10.3% of the total EU/EEA population but account for 25% (15%–35%) of all CHB cases. Migrants born in China and Romania contribute the largest number of infections, with over 100,000 estimated CHB cases each, followed by migrants from Turkey, Albania and Russia, in descending order, with over 50,000 estimated CHB cases each. The CHB prevalence reported in studies among migrants in EU/EEA countries was lower than the country of birth prevalence in 9 of 14 studies.

Conclusions

Migrants from endemic countries are disproportionately affected by CHB; their contribution however varies between EU/EEA countries. Migrant focused screening strategies would be most effective in countries with a high relative contribution of migrants and a low general population prevalence. In countries with a higher general population prevalence and a lower relative contribution of migrants, screening specific birth cohorts may be a more effective use of scarce resources. Quantifying the number of CHB infections among 50 different migrant groups residing in each of the 31 EU/EEA host countries helps to identify the most affected migrant communities who would benefit from targeted screening and linkage to care.
Zusatzmaterial
Additional file 1: Estimating the scale of chronic hepatitis B virus infection among migrants in EU/EEA countries. The ‘Chronic Hepatitis B (CHB) Additional file 1’ includes 9 annexes. Annexs 1, 2, 5 and 7 present data on the search strategy, the PRISMA flow chart, the inclusion and exclusion criteria of global/worldwide systematic reviews and meta-analyses and the rationale for the selected country specific hepatitis B and C prevalence figures. (ii) Annexs 3, 4 and 6 present data on the search strategy, the PRISMA flow chart and the inclusion and exclusion criteria for chronic hepatitis B/C prevalence studies among migrants in the EU/EEA. (iii) Annex 8 presents a list of the country specific HBsAg prevalence estimates selected along with the corresponding source. (iv) Annex 9 presents country tables which list the estimated number of Chronic Hepatitis B (CHB) cases among the 50 largest migrant populations residing in the individual EU/EEA host countries. (DOCX 487 kb)
Literatur
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