nach oben

Journal of Assisted Reproduction and Genetics

Erschienen in:

01.01.2013 | Fertility Preservation

Evaluation of ovarian and testicular tissue cryopreservation in children undergoing gonadotoxic therapies

verfasst von: Samir N. Babayev, Erol Arslan, Stanley Kogan, Fred Moy, Kutluk Oktay

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 1/2013

Einloggen, um Zugang zu erhalten

Abstract

Objective

Ovarian and testicular tissue cryopreservation are the only fertility preservation options for sexually immature individuals. Because of their experimental nature, it is important to determine safety and possible bundling with other medicallyindicated procedures.

Study design

Prospective observational.

Results

Cryopreservation indications included cancer in 75 % of females and 50 % of males, while non-cancer indications included various hematological conditions. Similar numbers of females (12/28) and males (3/9) underwent prior chemotherapy. Females underwent laparoscopic (27/28) or robotic (1/28) approaches while incisional biopsy was used in males. Bundling of ovarian and testicular harvesting with other medicallyindicated procedures was performed in 42 % and 22 %, respectively. The operative time inclusive of bundled procedures was similar (1.6 ± 0.1 vs. 0.9 ± 0.3 h) but the discharge time was significantly longer for females than males (10.4 ± 0.6 vs. 4.6 ± 0.6 h, p < 0.05) due to frequent bundling of medically-indicated procedures in females. All procedures were successfully completed without complications or significant blood loss.

Conclusions

Pediatric gonadal tissue cryopreservation can be combined with other medically-indicated procedures to minimize the potential inconvenience, additional anesthetic risks, and costs.

Akar M, Oktay K. Restoration of ovarian endocrine function by ovarian transplantation. Trends in endocrinology and metabolism: TEM 2005;16(8):374–80. doi:10.1016/j.tem.2005.06.011

AmericanCancerSociety. Cancer Facts & Figures 2010. American Cancer Society; 2010.

Andersen CY, Rosendahl M, Byskov AG, Loft A, Ottosen C, Dueholm M, et al. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod. 2008;23(10):2266–72. doi:10.1093/humrep/den244.PubMedCrossRef

Behringer K, Thielen I, Mueller H, Goergen H, Eibl AD, Rosenbrock J, Halbsguth T, Eichenauer DA, Fuchs M, Reiners KS, Renno JH, van der Ven K, Kuehr M, von Wolff M, Diehl V, Engert A, Borchmann P. Fertility and gonadal function in female survivors after treatment of early unfavorable Hodgkin lymphoma (HL) within the German Hodgkin Study Group HD14 trial. Annals of oncology : official journal of the European Society for Medical Oncology/ESMO 2012;23(7):1818–25. doi:10.1093/annonc/mdr575

Byrne J, Fears TR, Mills JL, Zeltzer LK, Sklar C, Meadows AT, et al. Fertility of long-term male survivors of acute lymphoblastic leukemia diagnosed during childhood. Pediatr Blood Canc. 2004;42(4):364–72. doi:10.1002/pbc.10449.CrossRef

Byrne J, Fears TR, Mills JL, Zeltzer LK, Sklar C, Nicholson HS, et al. Fertility in women treated with cranial radiotherapy for childhood acute lymphoblastic leukemia. Pediatr Blood Canc. 2004;42(7):589–97. doi:10.1002/pbc.20033.CrossRef

Chow EJ, Friedman DL, Yasui Y, Whitton JA, Stovall M, Robison LL, et al. Timing of menarche among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Pediatr Blood Canc. 2008;50(4):854–8. doi:10.1002/pbc.21316.CrossRef

Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med. 2006;354(17):1813–26. doi:10.1056/NEJMra052638.PubMedCrossRef

Couto-Silva AC, Trivin C, Thibaud E, Esperou H, Michon J, Brauner R. Factors affecting gonadal function after bone marrow transplantation during childhood. Bone marrow transplant. 2001;28(1):67–75. doi:10.1038/sj.bmt.1703089.PubMedCrossRef

10.

Demeestere I, Simon P, Emiliani S, Delbaere A, Englert Y. Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin’s disease. Oncologist. 2007;12(12):1437–42. doi:10.1634/theoncologist.12-12-1437.PubMedCrossRef

11.

Demeestere I, Simon P, Englert Y, Delbaere A. Preliminary experience of ovarian tissue cryopreservation procedure: alternatives, perspectives and feasibility. Reproductive Biomedicine Online. 2003;7(5):572–9.PubMedCrossRef

12.

Demirtas E, Elizur SE, Holzer H, Gidoni Y, Son WY, Chian RC, et al. Immature oocyte retrieval in the luteal phase to preserve fertility in cancer patients. Reproductive Biomedicine Online. 2008;17(4):520–3.PubMedCrossRef

13.

Dobrinski I. De novo morphogenesis of functional testis tissue after ectopic transplantation of isolated cells. Organogenesis. 2007;3(2):79–82.PubMedCrossRef

14.

Dolmans MM, Marinescu C, Saussoy P, Van Langendonckt A, Amorim C, Donnez J. Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe. Blood. 2010;116(16):2908–14. doi:10.1182/blood-2010-01-265751.PubMedCrossRef

15.

Fain-Kahn V, Poirot C, Uzan C, Prades M, Gouy S, Genestie C, et al. Feasibility of ovarian cryopreservation in borderline ovarian tumours. Hum Reprod. 2009;24(4):850–5. doi:10.1093/humrep/den459.PubMedCrossRef

16.

Feigin E, Abir R, Fisch B, Kravarusic D, Steinberg R, Nitke S, et al. Laparoscopic ovarian tissue preservation in young patients at risk for ovarian failure as a result of chemotherapy/irradiation for primary malignancy. J Pediatr Surg. 2007;42(5):862–4. doi:10.1016/j.jpedsurg.2006.12.041.PubMedCrossRef

17.

Ginsberg JP, Carlson CA, Lin K, Hobbie WL, Wigo E, Wu X, et al. An experimental protocol for fertility preservation in prepubertal boys recently diagnosed with cancer: a report of acceptability and safety. Hum Reprod. 2010;25(1):37–41. doi:10.1093/humrep/dep371.PubMedCrossRef

18.

Goossens E, Frederickx V, De Block G, Van Steirteghem AC, Tournaye H. Reproductive capacity of sperm obtained after germ cell transplantation in a mouse model. Hum Reprod. 2003;18(9):1874–80.PubMedCrossRef

19.

Green DM, Sklar CA, Boice Jr JD, Mulvihill JJ, Whitton JA, Stovall M, et al. Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2009;27(14):2374–81. doi:10.1200/JCO.2008.21.1839.CrossRef

20.

Lawrenz B, Rothmund R, Neunhoeffer E, Huebner S, Henes M. Fertility preservation in prepubertal girls prior to chemotherapy and radiotherapy-review of the literature. J Pediatr Adolesc Gynecol. 2012;25(5):284–8. doi:10.1016/j.jpag.2011.05.009.PubMedCrossRef

21.

Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, Beck LN, Brennan LV, Oktay K, American Society of Clinical O. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2006;24(18):2917–31. doi:10.1200/JCO.2006.06.5888

22.

Locatelli F, Giorgiani G, Pession A, Bozzola M. Late effects in children after bone marrow transplantation: a review. Haematologica. 1993;78(5):319–28.PubMed

23.

Madanat LM, Malila N, Dyba T, Hakulinen T, Sankila R, Boice Jr JD, et al. Probability of parenthood after early onset cancer: a population-based study. Int J Canc J Int Canc. 2008;123(12):2891–8. doi:10.1002/ijc.23842.CrossRef

24.

Meirow D. Reproduction post-chemotherapy in young cancer patients. Mol Cell Endocrinol. 2000;169(1–2):123–31.PubMedCrossRef

25.

Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353(3):318–21. doi:10.1056/NEJMc055237.PubMedCrossRef

26.

Oktay K, Buyuk E, Veeck L, Zaninovic N, Xu K, Takeuchi T, et al. Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;363(9412):837–40. doi:10.1016/S0140-6736(04)15728-0.PubMedCrossRef

27.

Oktay K, Economos K, Kan M, Rucinski J, Veeck L, Rosenwaks Z. Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm. JAMA. 2001;286(12):1490–3.PubMedCrossRef

28.

Oktay K, Karlikaya G. Ovarian function after transplantation of frozen, banked autologous ovarian tissue. N Engl J Med. 2000;342(25):1919. doi:10.1056/NEJM200006223422516.PubMedCrossRef

29.

Oktay K, Karlikaya GG, Aydin BA. Ovarian cryopreservation and transplantation: basic aspects. Mol Cell Endocrinol. 2000;169(1–2):105–8.PubMedCrossRef

30.

Oktay K, Nugent D, Newton H, Salha O, Chatterjee P, Gosden RG. Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue. Fertil Steril. 1997;67(3):481–6.PubMedCrossRef

31.

Oktay K, Oktem O. Ovarian cryopreservation and transplantation for fertility preservation for medical indications: report of an ongoing experience. Fertil Steril. 2010;93(3):762–8. doi:10.1016/j.fertnstert.2008.10.006.PubMedCrossRef

32.

Oktay K, Rodriguez-Wallberg KA, Sahin G. Fertility preservation by ovarian stimulation and oocyte cryopreservation in a 14-year-old adolescent with Turner syndrome mosaicism and impending premature ovarian failure. Fertility and sterility. 2010;94(2):753.e715–759. doi:10.1016/j.fertnstert.2010.01.044.CrossRef

33.

Oktem O, Oktay K. Quantitative assessment of the impact of chemotherapy on ovarian follicle reserve and stromal function. Cancer. 2007;110(10):2222–9. doi:10.1002/cncr.23071.PubMedCrossRef

34.

Poirot C, Vacher-Lavenu MC, Helardot P, Guibert J, Brugieres L, Jouannet P. Human ovarian tissue cryopreservation: indications and feasibility. Hum Reprod. 2002;17(6):1447–52.PubMedCrossRef

35.

Quinn GP, Murphy D, Knapp C, Stearsman DK, Bradley-Klug KL, Sawczyn K, Clayman ML. Who decides? Decision making and fertility preservation in teens with cancer: a review of the literature. The Journal of adolescent health: official publication of the Society for Adolescent Medicine 2011;49(4):337–46. doi:10.1016/j.jadohealth.2011.01.005

36.

Rodriguez-Wallberg KA, Oktay K. Fertility preservation medicine: options for young adults and children with cancer. J Pediatr Hematol Oncol. 2010;32(5):390–6. doi:10.1097/MPH.0b013e3181dce339.PubMed

37.

Rodriguez-Wallberg KA, Oktay K. Options on fertility preservation in female cancer patients. Canc Treat Rev. 2012;38(5):354–61. doi:10.1016/j.ctrv.2011.10.002.CrossRef

38.

Sato T, Katagiri K, Yokonishi T, Kubota Y, Inoue K, Ogonuki N, et al. In vitro production of fertile sperm from murine spermatogonial stem cell lines. Nat Comm. 2011;2:472. doi:10.1038/ncomms1478.CrossRef

39.

Schmidt KT, Larsen EC, Andersen CY, Andersen AN. Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease. BJOG: Int J Obstet Gynecol. 2010;117(2):163–74. doi:10.1111/j.1471-0528.2009.02408.x.CrossRef

40.

Shinohara T, Inoue K, Ogonuki N, Kanatsu-Shinohara M, Miki H, Nakata K, et al. Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination. Hum Reprod. 2002;17(12):3039–45.PubMedCrossRef

41.

Sklar CA, Mertens AC, Mitby P, Whitton J, Stovall M, Kasper C, et al. Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study. J Natl Canc Inst. 2006;98(13):890–6. doi:10.1093/jnci/djj243.CrossRef

42.

Soleimani R, Heytens E, Darzynkiewicz Z, Oktay K. Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. Aging. 2011;3(8):782–93.PubMed

43.

Song Y, Silversides FG. Production of offspring from cryopreserved chicken testicular tissue. Poult Sci. 2007;86(7):1390–6.PubMed

44.

Sonmezer M, Oktay K. Fertility preservation in female patients. Hum Reprod Updat. 2004;10(3):251–66. doi:10.1093/humupd/dmh021.CrossRef

45.

Telfer EE, McLaughlin M. In vitro development of ovarian follicles. Semin Reprod Med. 2011;29(1):15–23. doi:10.1055/s-0030-1268700.PubMedCrossRef

46.

van den Berg H, Repping S, van der Veen F. Parental desire and acceptability of spermatogonial stem cell cryopreservation in boys with cancer. Hum Reprod. 2007;22(2):594–7. doi:10.1093/humrep/del375.PubMedCrossRef

47.

Van Saen D, Goossens E, De Block G, Tournaye H. Regeneration of spermatogenesis by grafting testicular tissue or injecting testicular cells into the testes of sterile mice: a comparative study. Fertil Steril. 2009;91(5 Suppl):2264–72. doi:10.1016/j.fertnstert.2008.02.100.PubMedCrossRef

48.

Wallace WH, Shalet SM, Crowne EC, Morris-Jones PH, Gattamaneni HR. Ovarian failure following abdominal irradiation in childhood: natural history and prognosis. Clin Oncol. 1989;1(2):75–9.CrossRef

49.

Wenzel L, Dogan-Ates A, Habbal R, Berkowitz R, Goldstein DP, Bernstein M, et al. Defining and measuring reproductive concerns of female cancer survivors. J Natl Canc Inst Monogr. 2005;34:94–8. doi:10.1093/jncimonographs/lgi017.CrossRef

50.

Wyns C, Curaba M, Petit S, Vanabelle B, Laurent P, Wese JF, et al. Management of fertility preservation in prepubertal patients: 5 years’ experience at the Catholic University of Louvain. Hum Reprod. 2011;26(4):737–47. doi:10.1093/humrep/deq387.PubMedCrossRef

Titel: Evaluation of ovarian and testicular tissue cryopreservation in children undergoing gonadotoxic therapies
verfasst von: Samir N. Babayev
Erol Arslan
Stanley Kogan
Fred Moy
Kutluk Oktay
Publikationsdatum: 01.01.2013
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 1/2013
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-012-9909-5

Neu im Fachgebiet Gynäkologie und Geburtshilfe

23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Evaluation of ovarian and testicular tissue cryopreservation in children undergoing gonadotoxic therapies

Abstract

Objective

Study design

Results

Conclusions

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie

Springer Medizin

Abstract

Objective

Study design

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2013

Quality and functionality of human ovarian tissue after cryopreservation using an original slow freezing procedure

Association of the Glutathione S-transferases M1 and T1 polymorphism with male infertility: a meta-analysis

False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3

Do ACE I/D gene polymorphism serve as a predictive marker for age at onset in PCOS?

Fertilization, embryo development, and clinical outcome of immature oocytes obtained from natural cycle in vitro fertilization

The safety of transplanting cryopreserved ovarian tissue in cancer patients: a review of the literature

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie