The online version of this article (https://doi.org/10.1186/s12890-018-0573-0) contains supplementary material, which is available to authorized users.
Exacerbations of chronic obstructive pulmonary disease (COPD) are an important measure of disease severity in terms of impaired disease progression, increased recovery time, healthcare resource utilization, overall morbidity and mortality. We aimed to quantify exacerbation and healthcare resource utilization rates among COPD patients in Sweden with respect to baseline treatments, exacerbation history, and comorbidities.
Patients with a COPD or chronic bronchitis (CB) diagnosis in secondary care at age of ≥40 years on 1.7.2009 were identified and followed until 1.7.2010 or death. Severe exacerbations were defined as hospitalizations due to respiratory disease, and healthcare resource utilization was measured by all-cause hospitalizations and secondary care visits. Poisson regression was used adjusting for age, gender, time since COPD/CB diagnosis, and Charlson comorbidity index.
In 88,548 patients (54% females, mean age 72 years), previous respiratory hospitalizations and current high use of COPD medication (double or triple therapy) predicted an 8.3-fold increase in severe exacerbation rates and 1.8-fold increase in healthcare resource utilization rates in the following year, compared to patients without combination treatment and/or history of severe exacerbations.
COPD/CB patients with history of severe exacerbations and high use of COPD medication experienced a significantly increased rate of severe exacerbations and healthcare resource utilization during the one-year follow-up.
Additional file 1: Supplementary information. (DOC 96 kb)12890_2018_573_MOESM1_ESM.doc
From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017. Available from: http://goldcopd.org.
Lundbäck B, Gulsvik A, Albers M, Bakke P, Rönmark E, van den Boom G, et al. Epidemiological aspects and early detection of chronic obstructive airway diseases in the elderly. Eur Respir J. 2003;21:3s–9s. CrossRef
Årsrapport Luftvägsregistet 2012.pdf [Internet]. [cited 2014 Jun 11]. Available from: http://www.hjart-lung.se/contentassets/bc25586cdf9549b6884190535f554950/arsrapport-luftvagsregistet-2012.pdf.
Dal NR, Eandi M, Pradelli L, Iannazzo S. Cost-effectiveness and healthcare budget impact in Italy of inhaled corticosteroids and bronchodilators for severe and very severe COPD patients. Int. J. Chron. Obstruct. Pulmon. Dis. 2007;2:169–76. PubMed
- Exacerbations and healthcare resource utilization among COPD patients in a Swedish registry-based nation-wide study
Javaria Mona Khalid
- BioMed Central
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