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Erschienen in: Clinical Rheumatology 4/2020

01.02.2020 | Original Article

Experience of musculoskeletal ultrasound scanning improves physicians’ physical examination skills in assessment of synovitis

verfasst von: Aiko Saku, Shunsuke Furuta, Manami Kato, Hiroki Furuya, Kazumasa Suzuki, Masashi Fukuta, Kenichi Suehiro, Sohei Makita, Tomohiro Tamachi, Kei Ikeda, Hiroaki Takatori, Yuko Maezawa, Akira Suto, Kotaro Suzuki, Koichi Hirose, Hiroshi Nakajima

Erschienen in: Clinical Rheumatology | Ausgabe 4/2020

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Abstract

Objective

Musculoskeletal ultrasound (US) is more sensitive than physical examination in detecting synovitis and helps physicians to understand its pathophysiology. In this study, we aimed to determine if the experience in musculoskeletal US scanning is independently associated with improved physical examination skills to detect synovitis.

Method

Seventy patients with rheumatoid arthritis and twenty-three physicians were enrolled. Patients were first assessed by multiple physicians with a range of clinical/sonographic experience for the swelling of the wrist, metacarpophalangeal and proximal interphalangeal (PIP) joints and next underwent US assessment performed by another physician experienced in musculoskeletal US. We then calculated the positive/negative predictive values (PPV/NPV) of joint swelling to identify US-detected synovial hypertrophy. Finally, the factors independently associated with the accuracy of clinical assessment were identified by using multivariate analyses.

Results

One thousand five hundred forty joints were assessed 6116 times in total for swelling. Overall, PPV and NPV of joint swelling were 51.7% and 88.3%, respectively. Multivariate analyses identified wrist joint, tenderness, male and greater patients’ age as the factors significantly associated with higher PPV. In addition, there was a trend that longer experience in rheumatology clinical practice was associated with higher PPV (p = 0.058). On the other hand, longer experience in musculoskeletal US, PIP joint and positive rheumatoid factor were identified as the significant factors for higher NPV, while wrist joint, tenderness, presence of osteophyte and obesity as those for lower NPV.

Conclusion

Our data suggest that the experience in musculoskeletal US improves physical examination skills particularly to avoid overestimation.
Key Points
Physicians with longer US experience are less likely to overestimate synovitis by physical examination.
Musculoskeletal US is a useful tool for rheumatologists to improve their physical examination skill.
Presence of osteophytes, joint tenderness and obesity influence the accuracy of physical examination of joints.
Literatur
1.
Zurück zum Zitat Smolen JS, Landewé R, Bijlsma J, Burmester G, Chatzidionysiou K, Dougados M et al (2017) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis 76:960–977CrossRef Smolen JS, Landewé R, Bijlsma J, Burmester G, Chatzidionysiou K, Dougados M et al (2017) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis 76:960–977CrossRef
2.
Zurück zum Zitat Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K et al (2013) Ultrasound can improve the accuracy of the 2010 American College of Rheumatology/European League against rheumatism classification criteria for rheumatoid arthritis to predict the requirement for methotrexate treatment. Arthritis Rheum 65:890–898CrossRef Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K et al (2013) Ultrasound can improve the accuracy of the 2010 American College of Rheumatology/European League against rheumatism classification criteria for rheumatoid arthritis to predict the requirement for methotrexate treatment. Arthritis Rheum 65:890–898CrossRef
3.
Zurück zum Zitat Paulshus Sundlisæter N, Aga AB, Olsen IC, Hammer HB, Uhlig T, van der Heijde D et al (2018) Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: associations to future good radiographic and physical outcomes. Ann Rheum Dis 77:1421–1425PubMed Paulshus Sundlisæter N, Aga AB, Olsen IC, Hammer HB, Uhlig T, van der Heijde D et al (2018) Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: associations to future good radiographic and physical outcomes. Ann Rheum Dis 77:1421–1425PubMed
4.
Zurück zum Zitat Kawashiri SY, Suzuki T, Okada A, Yamasaki S, Tamai M, Nakamura H, Origuchi T, Mizokami A, Uetani M, Aoyagi K, Eguchi K, Kawakami A (2013) Musculoskeletal ultrasonography assists the diagnostic performance of the 2010 classification criteria for rheumatoid arthritis. Mod Rheumatol 23:36–43CrossRef Kawashiri SY, Suzuki T, Okada A, Yamasaki S, Tamai M, Nakamura H, Origuchi T, Mizokami A, Uetani M, Aoyagi K, Eguchi K, Kawakami A (2013) Musculoskeletal ultrasonography assists the diagnostic performance of the 2010 classification criteria for rheumatoid arthritis. Mod Rheumatol 23:36–43CrossRef
5.
Zurück zum Zitat Ikeda K, Nakagomi D, Sanayama Y, Yamagata M, Okubo A, Iwamoto T et al (2013) Correlation of radiographic progression with the cumulative activity of synovitis estimated by power Doppler ultrasound in rheumatoid arthritis: difference between patients treated with methotrexate and those treated with biological agents. J Rheumatol 40:1967–1976CrossRef Ikeda K, Nakagomi D, Sanayama Y, Yamagata M, Okubo A, Iwamoto T et al (2013) Correlation of radiographic progression with the cumulative activity of synovitis estimated by power Doppler ultrasound in rheumatoid arthritis: difference between patients treated with methotrexate and those treated with biological agents. J Rheumatol 40:1967–1976CrossRef
6.
Zurück zum Zitat Naredo E, Bonilla G, Gamero F, Uson J, Carmona L, Laffon A (2005) Assessment of inflammatory activity in rheumatoid arthritis: a comparative study of clinical evaluation with grey scale and power Doppler ultrasonography. Ann Rheum Dis 64:375–381CrossRef Naredo E, Bonilla G, Gamero F, Uson J, Carmona L, Laffon A (2005) Assessment of inflammatory activity in rheumatoid arthritis: a comparative study of clinical evaluation with grey scale and power Doppler ultrasonography. Ann Rheum Dis 64:375–381CrossRef
7.
Zurück zum Zitat Iwamoto T, Ikeda K, Hosokawa J, Yamagata M, Tanaka S, Norimoto A, Sanayama Y, Nakagomi D, Takahashi K, Hirose K, Sugiyama T, Sueishi M, Nakajima H (2014) Prediction of relapse after discontinuation of biologic agents by ultrasonographic assessment in patients with rheumatoid arthritis in clinical remission: high predictive values of total gray-scale and power Doppler scores that represent residual synovial inflammation before discontinuation. Arthritis Care Res 66:1576–1581CrossRef Iwamoto T, Ikeda K, Hosokawa J, Yamagata M, Tanaka S, Norimoto A, Sanayama Y, Nakagomi D, Takahashi K, Hirose K, Sugiyama T, Sueishi M, Nakajima H (2014) Prediction of relapse after discontinuation of biologic agents by ultrasonographic assessment in patients with rheumatoid arthritis in clinical remission: high predictive values of total gray-scale and power Doppler scores that represent residual synovial inflammation before discontinuation. Arthritis Care Res 66:1576–1581CrossRef
8.
Zurück zum Zitat Naredo E, Moller I, Cruz A, Carmona L, Garrido J (2008) Power Doppler ultrasonographic monitoring of response to anti–tumor necrosis factor therapy in patients with rheumatoid arthritis. Arthritis Rheum 58:2248–2256CrossRef Naredo E, Moller I, Cruz A, Carmona L, Garrido J (2008) Power Doppler ultrasonographic monitoring of response to anti–tumor necrosis factor therapy in patients with rheumatoid arthritis. Arthritis Rheum 58:2248–2256CrossRef
9.
Zurück zum Zitat Joplin SK, van der Zwan R, Bagga H, Joshua F, Wong PK (2016) Pilot study assessing the novel use of musculoskeletal ultrasound in patients with rheumatoid arthritis to improve patient attitudes and adherence to medication. Int J Rheum Dis 19:658–664CrossRef Joplin SK, van der Zwan R, Bagga H, Joshua F, Wong PK (2016) Pilot study assessing the novel use of musculoskeletal ultrasound in patients with rheumatoid arthritis to improve patient attitudes and adherence to medication. Int J Rheum Dis 19:658–664CrossRef
10.
Zurück zum Zitat Joplin S, van der Zwan R, Joshua F, Wong PK (2015) Medication adherence in patients with rheumatoid arthritis: the effect of patient education, health literacy, and musculoskeletal ultrasound. Biomed Res Int 2015:150658CrossRef Joplin S, van der Zwan R, Joshua F, Wong PK (2015) Medication adherence in patients with rheumatoid arthritis: the effect of patient education, health literacy, and musculoskeletal ultrasound. Biomed Res Int 2015:150658CrossRef
11.
Zurück zum Zitat Cheung PP, Lahiri M, Teng GG, Lim AY, Lau TC, Lateef A et al (2015) A randomized controlled trial for improving patient self-assessment of synovitis in rheumatoid arthritis with education by ultrasonography: the RAEUS Study. Rheumatology (Oxford) 54:1161–1169CrossRef Cheung PP, Lahiri M, Teng GG, Lim AY, Lau TC, Lateef A et al (2015) A randomized controlled trial for improving patient self-assessment of synovitis in rheumatoid arthritis with education by ultrasonography: the RAEUS Study. Rheumatology (Oxford) 54:1161–1169CrossRef
12.
Zurück zum Zitat Ogasawara M, Murayama G, Yamada Y, Nemoto T, Kageyama M, Toyama S, Kusaoi M, Onuma S, Kon T, Sekiya F, Sugimoto K, Matsudaira R, Matsushita M, Tada K, Kempe K, Yamaji K, Tamura N, Takasaki Y (2012) Autofeedback from ultrasound images provides rapid improvement in palpation skills for identifying joint swelling in rheumatoid arthritis. J Rheumatol 39:1207–1214CrossRef Ogasawara M, Murayama G, Yamada Y, Nemoto T, Kageyama M, Toyama S, Kusaoi M, Onuma S, Kon T, Sekiya F, Sugimoto K, Matsudaira R, Matsushita M, Tada K, Kempe K, Yamaji K, Tamura N, Takasaki Y (2012) Autofeedback from ultrasound images provides rapid improvement in palpation skills for identifying joint swelling in rheumatoid arthritis. J Rheumatol 39:1207–1214CrossRef
13.
Zurück zum Zitat Murayama G, Ogasawara M, Nemoto T, Yamada Y, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y (2013) Clinical miscount of involved joints denotes the need for ultrasound complementation in usual practice for patients with rheumatoid arthritis. Clin Exp Rheumatol 31:506–514PubMed Murayama G, Ogasawara M, Nemoto T, Yamada Y, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y (2013) Clinical miscount of involved joints denotes the need for ultrasound complementation in usual practice for patients with rheumatoid arthritis. Clin Exp Rheumatol 31:506–514PubMed
14.
Zurück zum Zitat Sifuentes-Cantú C, Contreras-Yáñez I, Saldarriaga L, Lozada AC, Gutiérrez M, Pascual-Ramos V (2017) The added value of musculoskeletal ultrasound to clinical evaluation in the treatment decision of rheumatoid arthritis outpatients: physician experience matters. BMC Musculoskelet Disord 18:390CrossRef Sifuentes-Cantú C, Contreras-Yáñez I, Saldarriaga L, Lozada AC, Gutiérrez M, Pascual-Ramos V (2017) The added value of musculoskeletal ultrasound to clinical evaluation in the treatment decision of rheumatoid arthritis outpatients: physician experience matters. BMC Musculoskelet Disord 18:390CrossRef
15.
Zurück zum Zitat Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd et al (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League against rheumatism collaborative initiative. Arthritis Rheum 62:2569–2581CrossRef Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd et al (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League against rheumatism collaborative initiative. Arthritis Rheum 62:2569–2581CrossRef
16.
Zurück zum Zitat D'Agostino MA, Terslev L, Aegerter P, Backhaus M, Balint P, Bruyn GA et al (2017) Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-part 1: definition and development of a standardised, consensus-based scoring system. RMD Open 3:e000428CrossRef D'Agostino MA, Terslev L, Aegerter P, Backhaus M, Balint P, Bruyn GA et al (2017) Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-part 1: definition and development of a standardised, consensus-based scoring system. RMD Open 3:e000428CrossRef
17.
Zurück zum Zitat Terslev L, Naredo E, Aegerter P, Wakefield RJ, Backhaus M, Balint P et al (2017) Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-part 2: reliability and application to multiple joints of a standardised consensus-based scoring system. RMD Open 3:e000427CrossRef Terslev L, Naredo E, Aegerter P, Wakefield RJ, Backhaus M, Balint P et al (2017) Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-part 2: reliability and application to multiple joints of a standardised consensus-based scoring system. RMD Open 3:e000427CrossRef
18.
Zurück zum Zitat Padovano I, Costantino F, Breban M, D’Agostino MA (2016) Prevalence of ultrasound synovial inflammatory findings in healthy subjects. Ann Rheum Dis 75:1819–1823CrossRef Padovano I, Costantino F, Breban M, D’Agostino MA (2016) Prevalence of ultrasound synovial inflammatory findings in healthy subjects. Ann Rheum Dis 75:1819–1823CrossRef
19.
Zurück zum Zitat Witt M, Mueller F, Nigg A, Reindl C, Leipe J, Proft F, Stein N, Hammitzsch A, Mayer S, Dechant C, Schulze-Koops H, Grunke M (2013) Relevance of grade 1 gray-scale ultrasound findings in wrists and small joints to the assessment of subclinical synovitis in rheumatoid arthritis. Arthritis Rheum 65:1694–1701CrossRef Witt M, Mueller F, Nigg A, Reindl C, Leipe J, Proft F, Stein N, Hammitzsch A, Mayer S, Dechant C, Schulze-Koops H, Grunke M (2013) Relevance of grade 1 gray-scale ultrasound findings in wrists and small joints to the assessment of subclinical synovitis in rheumatoid arthritis. Arthritis Rheum 65:1694–1701CrossRef
20.
Zurück zum Zitat Woods R, Wisniewski SJ, Lueders DR, Pittelkow TP, Larson DR, Finnoff JT (2018) Can ultrasound be used to improve the palpation skills of physicians in training? A Prospective Study PM R 10:730–737PubMed Woods R, Wisniewski SJ, Lueders DR, Pittelkow TP, Larson DR, Finnoff JT (2018) Can ultrasound be used to improve the palpation skills of physicians in training? A Prospective Study PM R 10:730–737PubMed
21.
Zurück zum Zitat Ruiz-Curiel A, Díaz-Barreda MD, González-Rodríguez M, Martín-Delgado T, Medrano-Antoñazas A, Muñoz-González R, Perales-Torres S, Sánchez-Montero J, Janta I, Nieto JC, Collado-Yurrita L, López-Longo FJ, Naredo E (2016) Musculoskeletal ultrasound: an effective tool to help medical students improve joint inflammation detection? Med Ultrason 18:294–298CrossRef Ruiz-Curiel A, Díaz-Barreda MD, González-Rodríguez M, Martín-Delgado T, Medrano-Antoñazas A, Muñoz-González R, Perales-Torres S, Sánchez-Montero J, Janta I, Nieto JC, Collado-Yurrita L, López-Longo FJ, Naredo E (2016) Musculoskeletal ultrasound: an effective tool to help medical students improve joint inflammation detection? Med Ultrason 18:294–298CrossRef
22.
Zurück zum Zitat Swamy M, Searle RF (2012) Anatomy teaching with portable ultrasound to medical students. BMC Med Educ 12:99CrossRef Swamy M, Searle RF (2012) Anatomy teaching with portable ultrasound to medical students. BMC Med Educ 12:99CrossRef
23.
Zurück zum Zitat Rempell JS, Saldana F, DiSalvo D, Kumar N, Stone MB, Chan W, Luz J, Noble VE, Liteplo A, Kimberly H, Kohler MJ (2016) Pilot point-of-care ultrasound curriculum at Harvard Medical School: early experience. West J Emerg Med 17:734–740CrossRef Rempell JS, Saldana F, DiSalvo D, Kumar N, Stone MB, Chan W, Luz J, Noble VE, Liteplo A, Kimberly H, Kohler MJ (2016) Pilot point-of-care ultrasound curriculum at Harvard Medical School: early experience. West J Emerg Med 17:734–740CrossRef
24.
Zurück zum Zitat Bauer EM, Ben-Artzi A, Duffy EL, Elashoff DA, Vangala SS, Fitzgerald J et al (2017) Joint-specific assessment of swelling and power Doppler in obese rheumatoid arthritis patients. BMC Musculoskelet Disord 18:99CrossRef Bauer EM, Ben-Artzi A, Duffy EL, Elashoff DA, Vangala SS, Fitzgerald J et al (2017) Joint-specific assessment of swelling and power Doppler in obese rheumatoid arthritis patients. BMC Musculoskelet Disord 18:99CrossRef
25.
Zurück zum Zitat Goossens J, Coustet B, Palazzo E, Dieudé P, Ottaviani S (2018) Overweight and obesity affect clinical assessment of synovitis in rheumatoid arthritis: comparison of ultrasonography and clinical exam. Clin Exp Rheumatol 37(1):49–54PubMed Goossens J, Coustet B, Palazzo E, Dieudé P, Ottaviani S (2018) Overweight and obesity affect clinical assessment of synovitis in rheumatoid arthritis: comparison of ultrasonography and clinical exam. Clin Exp Rheumatol 37(1):49–54PubMed
26.
Zurück zum Zitat George MD, Østergaard M, Conaghan PG, Emery P, Baker DG, Baker JF (2017) Obesity and rates of clinical remission and low MRI inflammation in rheumatoid arthritis. Ann Rheum Dis 76:1743–1746CrossRef George MD, Østergaard M, Conaghan PG, Emery P, Baker DG, Baker JF (2017) Obesity and rates of clinical remission and low MRI inflammation in rheumatoid arthritis. Ann Rheum Dis 76:1743–1746CrossRef
27.
Zurück zum Zitat Vidal C, Barnetche T, Morel J, Combe B, Daïen C (2015) Association of body mass index categories with disease activity and radiographic joint damage in rheumatoid arthritis: a systematic review and metaanalysis. J Rheumatol 42:2261–2269CrossRef Vidal C, Barnetche T, Morel J, Combe B, Daïen C (2015) Association of body mass index categories with disease activity and radiographic joint damage in rheumatoid arthritis: a systematic review and metaanalysis. J Rheumatol 42:2261–2269CrossRef
Metadaten
Titel
Experience of musculoskeletal ultrasound scanning improves physicians’ physical examination skills in assessment of synovitis
verfasst von
Aiko Saku
Shunsuke Furuta
Manami Kato
Hiroki Furuya
Kazumasa Suzuki
Masashi Fukuta
Kenichi Suehiro
Sohei Makita
Tomohiro Tamachi
Kei Ikeda
Hiroaki Takatori
Yuko Maezawa
Akira Suto
Kotaro Suzuki
Koichi Hirose
Hiroshi Nakajima
Publikationsdatum
01.02.2020
Verlag
Springer London
Erschienen in
Clinical Rheumatology / Ausgabe 4/2020
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-020-04960-5

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