Background
Methods
Animals
Tissue Water Content and the permeability-surface area product (PS) for [51Cr]-EDTA
Evans blue
Photo microscopy
Statistical analysis
Results
Physiological data
Vehicle (n = 6) | CFA 2 h (n = 6) | CFA 24 h (n = 5) | CFA 48 h (n = 5) | IS 2 h (n = 6) | IS 24 h (n = 4) | |
---|---|---|---|---|---|---|
MAP (mmHg) | 98 ± 7 | 88 ± 3 | 87 ± 6 | 105 ± 7 | 85 ± 5 | 104 ± 9 |
Hct (%) | 50 ± 2 | 46 ± 3 | 38 ± 2* | 42 ± 1 | 46 ± 2 | 42 ± 2 |
pCO2 (kPa) | 4.6 ± 0.1 | 4.6 ± 0.1 | 4.7 ± 0.2 | 4.5 ± 0.1 | 4.6 ± 0.1 | 4.8 ± 0.2 |
pO2 (kPa) | 11.5 ± 0.1 | 11.6 ± 0.1 | 11.0 ± 0.2 | 12.7 ± 0.5 | 11.4 ± 0.3 | 11.4 ± 0.5 |
Na+ (mmol) | 136.3 ± 0.6 | 138.0 ± 1.6 | 138.6 ± 1.0 | 137.0 ± 0.5 | 137.0 ± 0.5 | 136.5 ± 0.9 |
K+(mmol) | 4.82 ± 0.39 | 4.65 ± 0.39 | 4.36 ± 0.13 | 4.40 ± 0.13 | 4.57 ± 0.14 | 4.55 ± 0.22 |
pH | 7.50 ± 0.02 | 7.45 ± 0.02 | 7.46 ± 0.02 | 7.46 ± 0.01 | 7.48 ± 0.01 | 7.48 ± 0.01 |
Photo microscopy
Permeability-surface area product for [51Cr]- EDTA
Control | CFA 2 h | CFA 24 h | CFA 48 h | IS 2 h | IS 24 h | |
---|---|---|---|---|---|---|
Cortex (μL/mg) | 7.3 + 0.6 | 12.2 ± 2.5 | 12.6 ± 0.8* | 14.6 + 3.0* | 11.3 ± 0.7* | 11.0 ± 2.0 |
PAG (μL/mg) | 6.0 ± 0.6 | 15.3 ± 3.2* | 12.8 ± 1.4* | 8.8 ± 1.5 | 13.8 ± 2.9 | 11.8 ± 2.3 |
Cerebellum (μL/mg) | 9.5 ± 0.4 | 14.2 ± 0.8* | 12.8 ± 0.5 | 29.4 ± 6.2 * | 13.8 ± 1.7 | 16.3 ± 1.3* |
L Spinal Trigeminal nucleus (μL/mg) | 10.3 ± 1.7 | 14.3 ± 2.3 | 21.2 ± 2.1* | 44.0 ± 14.4* | 12.5 ± 3.5* | 27.0 ± 8.9 |
R Spinal Trigeminal nucleus (μL/mg) | 12.8 ± 2.6 | 13.7 ± 1.6 | 19.4 ± 1.8 | 23.6 ± 3.4* | 16.0 ± 1.8 | 28.0 ± 11.0 |
L Trigeminal Ganglion (μL/mg) | 52.3 ± 4.3 | 53.3 ± 12.5 | 48.0 ± 8.0 | 25.8 ± 3.1 | 40.5 ± 13.4 | 59.3 ± 10.3 |
R Trigeminal Ganglion (μL/min/g) | 54.5 ± 5.7 | 51.7 ± 10.4 | 68.2 ± 13.9 | 22.0 ± 2.6 | 56.7 ± 15.5 | 83.8 ± 27.4 |