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Erschienen in: Urolithiasis 6/2003

01.12.2003 | Original Paper

Expression of mitotic Aurora/Ipl1p-related kinases in renal cell carcinomas: an immunohistochemical study

verfasst von: Hidetoshi Ehara, Shigeaki Yokoi, Masayoshi Tamaki, Yoshinori Nishino, Yoshito Takahashi, Takashi Deguchi, Masashi Kimura, Takashi Yoshioka, Yukio Okano

Erschienen in: Urolithiasis | Ausgabe 6/2003

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Abstract

The Aurora/Ipl1p-related kinases, AIRK1, AIRK2 and AIRK3, are members of a novel family of oncogenic serine/threonine kinases regulated by cell cycle progression and involved in chromosome segregation and cytokinesis. In this study, we examined expression of members of the AIRK family in human renal cell carcinomas. Expression of AIRK subfamilies was examined in 64 renal cell carcinomas by immunohistochemistry. Immunostaining of AIRK1, AIRK2 and AIRK3 was observed in 95%, 47% and 98% of specimens, respectively. Moreover, in specimens from the same patient, staining of AIRK2 was correlated with proliferating cell nuclear antigen labeling. Here we provide the first description of AIRK isozyme immunostaining in human renal cell carcinoma. Although the precise physiological functions of these kinases are not known, AIRK subfamily expression may play a role in renal cell carcinoma tumorigenesis.
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Metadaten
Titel
Expression of mitotic Aurora/Ipl1p-related kinases in renal cell carcinomas: an immunohistochemical study
verfasst von
Hidetoshi Ehara
Shigeaki Yokoi
Masayoshi Tamaki
Yoshinori Nishino
Yoshito Takahashi
Takashi Deguchi
Masashi Kimura
Takashi Yoshioka
Yukio Okano
Publikationsdatum
01.12.2003
Verlag
Springer-Verlag
Erschienen in
Urolithiasis / Ausgabe 6/2003
Print ISSN: 2194-7228
Elektronische ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-003-0354-x

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