Background
Methods
Patients
Characteristics | Cases | Survivin cytoplasm | Survivin nucleus | |||||
---|---|---|---|---|---|---|---|---|
IRS | 0-2 | 3-4 | 6-8 | 9-12 | 0-2 | 3-4 | 6-8 | |
Staining | negative | weak | moderate | strong | negative | weak | moderate | |
No.
| 50 | 8 | 15 | 19 | 8 | 29 | 10 | 11 |
Sex
| ||||||||
Male | 21 | 4 | 6 | 8 | 3 | 14 | 4 | 3 |
Female | 29 | 4 | 9 | 11 | 5 | 15 | 6 | 8 |
Histological subtype
| ||||||||
Leiomyosarcoma | 24 | 4 | 9 | 10 | 1 | 12 | 8 | 4 |
Synovial sarcoma | 26 | 4 | 6 | 9 | 7 | 17 | 2 | 7 |
Tumor grade
| ||||||||
I | 5 | 1 | 1 | 2 | 1 | 3 | 1 | 1 |
II | 21 | 5 | 2 | 10 | 4 | 11 | 6 | 4 |
III | 24 | 9 | 5 | 7 | 3 | 15 | 3 | 6 |
Tumor stage
| ||||||||
stage I | 5 | 0 | 1 | 3 | 1 | 2 | 2 | 1 |
stage II | 22 | 5 | 3 | 11 | 3 | 15 | 2 | 5 |
stage III | 17 | 2 | 8 | 5 | 2 | 9 | 4 | 4 |
stage IV | 6 | 1 | 3 | 0 | 2 | 3 | 2 | 1 |
Complete resection
| ||||||||
radical (R0) | 38 | 5 | 11 | 15 | 7 | 23 | 7 | 8 |
not radical (R1) | 12 | 3 | 4 | 4 | 1 | 6 | 3 | 3 |
Localization
| ||||||||
extremities | 33 | 6 | 10 | 10 | 7 | 18 | 7 | 8 |
trunc wall | 3 | 0 | 2 | 0 | 1 | 2 | 0 | 1 |
head/neck | 2 | 1 | 0 | 1 | 0 | 2 | 0 | 0 |
abdomen/retro- | 12 | 1 | 3 | 8 | 0 | 7 | 3 | 2 |
peritoneum | ||||||||
Patients follow-up
| ||||||||
alive | 18 | 2 | 6 | 7 | 3 | 10 | 6 | 2 |
dead | 32 | 6 | 9 | 12 | 5 | 19 | 4 | 9 |
Immunohistochemical detection
Survivin protein-level | Cytoplasm | Nucleus | ||||
---|---|---|---|---|---|---|
N | RR | P | N | RR | P | |
Svv weak (IRS = 3-4) | 15 | reference | 10 | reference | ||
Svv negative(IRS = 0-2) | 8 | 4.2 | 0.055 | 29 | 3.1 | 0.110 |
Svv moderate (IRS = 6-8) | 19 |
5.7
|
0.004
| 11 |
5.7
|
0.022
|
Svv strong (IRS = 9-12) | 8 | 2.4 | 0.241 | none | ||
Combined Svv protein levels
| ||||||
Svv cytopl. & nucleus weak (IRS = 3-4)1
| 6 | reference | ||||
Svv all other cases | 35 |
9.4
|
0.024
| |||
Svv cytopl. & nucleus moderate+strong (IRS ≥ 6)2
| 9 |
24.8
|
0.003
|