Erschienen in:
24.01.2017 | Research Letter
Expression of YAP1 in aggressive thyroid cancer
verfasst von:
Marilena Celano, Chiara Mignogna, Francesca Rosignolo, Marialuisa Sponziello, Michelangelo Iannone, Saverio Massimo Lepore, Giovanni Enrico Lombardo, Valentina Maggisano, Antonella Verrienti, Stefania Bulotta, Cosimo Durante, Carla Di Loreto, Giuseppe Damante, Diego Russo
Erschienen in:
Endocrine
|
Ausgabe 1/2018
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Excerpt
The Hippo signal transduction pathway plays a crucial role in the control of cellular proliferation, and its deregulation is believed to be involved in neoplastic transformation [
1,
2]. A wide array of human cancers show a down-regulation of Hippo pathway, resulting in the activation of the co-transcription factors Yes-associated protein 1 (YAP1) and Transcriptional coactivator with PDZ-binding motif (TAZ). In turn, the YAP/TAZ complex increases transcription of target proteins with oncogenic activity [
1,
2]. Thus, targeting YAP1 has been tested to arrest cancer cell proliferation [
3,
4]. …
