Skip to main content
Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy 7/2015

01.07.2015 | Knee

Failures in bipolar fresh osteochondral allograft for the treatment of end-stage knee osteoarthritis

verfasst von: S. Giannini, R. Buda, A. Ruffilli, G. Pagliazzi, A. Ensini, B. Grigolo, G. Desando, F. Vannini

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 7/2015

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Bipolar fresh osteochondral allografts (BFOA) recently became a fascinating option for articular cartilage replacement, in particular in those young patients non-suitable for traditional replacement because of age. While the use of osteochondral allografts for the treatment of focal osteochondral lesions in the knee is well established, their use in the treatment of end-stage arthritis is far more controversial. The purpose of this paper is to describe our experience in a series of seven patients who underwent a resurfacing of both tibio-femoral and patello-femoral joints by BFOA.

Methods

From 2005 to 2007, seven patients (mean age 35.2 ± 6.3 years) underwent BFOA for end-stage arthritis of the knee. Patients were evaluated clinically, radiographically and by CT scan preoperatively and at established intervals up to the final follow-up.

Results

No intra-operative complications occurred. Nevertheless, joint laxity and aseptic effusion, along with a progressive chondrolysis, lead to early BFOA failure in six patients, which were revised by total knee arthroplasty at 19.5 ± 3.9 months follow-up. Only one patient, who received the allograft to convert a knee arthrodesis, gained a satisfactory result at the last follow-up control.

Conclusions

BFOA in the knee joint still remains an inapplicable option in the treatment of post-traumatic end-stage arthritis of the young patient, due to the high rate of failure. Further studies are necessary in order to investigate the causes of failure and improve the applicability of this method. Still, after extensive counselling with the patient, BFOA may represent a salvage procedure aimed to revise scarcely tolerated knee arthrodesis.

Level of evidence

Retrospective case series, Level IV.
Literatur
2.
Zurück zum Zitat Baker PN, Meulen JH, Lewsey J, Gregg PJ (2007) The role of pain and function in determining patient satisfaction after total knee replacement. Data from the National Joint Registry for England and Wales. J Bone Joint Surg Br 89:893–900PubMedCrossRef Baker PN, Meulen JH, Lewsey J, Gregg PJ (2007) The role of pain and function in determining patient satisfaction after total knee replacement. Data from the National Joint Registry for England and Wales. J Bone Joint Surg Br 89:893–900PubMedCrossRef
3.
Zurück zum Zitat Beaver RJ, Mahomed M, Backstein D et al (1992) Fresh osteochondral allografts for post-traumatic defects in the knee. A survivorship analysis. J Bone Joint Surg Br 74(1):105–110PubMed Beaver RJ, Mahomed M, Backstein D et al (1992) Fresh osteochondral allografts for post-traumatic defects in the knee. A survivorship analysis. J Bone Joint Surg Br 74(1):105–110PubMed
4.
Zurück zum Zitat Bullens PH, Loon CJ, Waal Malefijt MC, Laan RF, Veth RP (2001) Patient satisfaction after total knee arthroplasty: a comparison between subjective and objective outcome assessments. J Arthroplasty 16:740–747PubMedCrossRef Bullens PH, Loon CJ, Waal Malefijt MC, Laan RF, Veth RP (2001) Patient satisfaction after total knee arthroplasty: a comparison between subjective and objective outcome assessments. J Arthroplasty 16:740–747PubMedCrossRef
5.
Zurück zum Zitat Czitrom AA, Keating S, Gross AE (1990) The viability of articular cartilage in fresh osteochondral allografts after clinical transplantation. J Bone Joint Surg Am 72(4):574–581PubMed Czitrom AA, Keating S, Gross AE (1990) The viability of articular cartilage in fresh osteochondral allografts after clinical transplantation. J Bone Joint Surg Am 72(4):574–581PubMed
6.
Zurück zum Zitat Emmerson BC, Gortz S, Jamali AA, Chung C, Amiel D, Bugbee WD (2007) Fresh osteochondral allografting in the treatment of osteochondritis dissecans of the femoral condyle. Am J Sports Med 35:907–914PubMedCrossRef Emmerson BC, Gortz S, Jamali AA, Chung C, Amiel D, Bugbee WD (2007) Fresh osteochondral allografting in the treatment of osteochondritis dissecans of the femoral condyle. Am J Sports Med 35:907–914PubMedCrossRef
7.
Zurück zum Zitat Flynn JM, Springfield DS, Mankin HJ (1994) Osteoarticular allografts to treat distal femoral osteonecrosis. Clin Orthop Relat Res 303:38–43PubMed Flynn JM, Springfield DS, Mankin HJ (1994) Osteoarticular allografts to treat distal femoral osteonecrosis. Clin Orthop Relat Res 303:38–43PubMed
8.
Zurück zum Zitat Giannini S, Buda R, Grigolo B, Bevoni R, Di Caprio F, Ruffilli A, Cavallo M, Desando G, Vannini F (2010) Bipolar fresh osteochondral allograft of the ankle. Foot Ankle Int 31(1):38–46PubMedCrossRef Giannini S, Buda R, Grigolo B, Bevoni R, Di Caprio F, Ruffilli A, Cavallo M, Desando G, Vannini F (2010) Bipolar fresh osteochondral allograft of the ankle. Foot Ankle Int 31(1):38–46PubMedCrossRef
9.
Zurück zum Zitat Giannini S, Buda R, Cavallo M, Ruffilli A, Grigolo B, Fornasari PM, Vannini F (2012) Bipolar fresh osteochondral allograft for the treatment of glenohumeral post-traumatic arthritis. Knee Surg Sports Traumatol Arthrosc 20(10):1953–1957PubMedCrossRef Giannini S, Buda R, Cavallo M, Ruffilli A, Grigolo B, Fornasari PM, Vannini F (2012) Bipolar fresh osteochondral allograft for the treatment of glenohumeral post-traumatic arthritis. Knee Surg Sports Traumatol Arthrosc 20(10):1953–1957PubMedCrossRef
10.
Zurück zum Zitat Giannini S, Buda R, Ruffilli A, Pagliazzi G, Vannini F (2013) Total femoral and tibial osteochondral allograft for remobilizing a knee after arthrodesis. Knee Surg Sports Traumatol Arthrosc 21(12):2784–2789PubMedCrossRef Giannini S, Buda R, Ruffilli A, Pagliazzi G, Vannini F (2013) Total femoral and tibial osteochondral allograft for remobilizing a knee after arthrodesis. Knee Surg Sports Traumatol Arthrosc 21(12):2784–2789PubMedCrossRef
11.
Zurück zum Zitat Giannini S, Buda R, Ruffilli A, Pagliazzi G, Vannini F (2013) Bipolar fresh osteochondral allograft for the treatment of hallux rigidus. Foot Ankle Int 34(6):908–911PubMedCrossRef Giannini S, Buda R, Ruffilli A, Pagliazzi G, Vannini F (2013) Bipolar fresh osteochondral allograft for the treatment of hallux rigidus. Foot Ankle Int 34(6):908–911PubMedCrossRef
12.
Zurück zum Zitat Gomoll AH, Filardo G, Almqvist FK, Bugbee WD, Jelic M, Monllau JC, Puddu G, Rodkey WG, Verdonk P, Verdonk R, Zaffagnini S, Marcacci M (2002) Surgical treatment for early osteoarthritis. Part II: allografts and concurrent procedures. Knee Surg Sports Traumatol Arthrosc 20(3):468–486CrossRef Gomoll AH, Filardo G, Almqvist FK, Bugbee WD, Jelic M, Monllau JC, Puddu G, Rodkey WG, Verdonk P, Verdonk R, Zaffagnini S, Marcacci M (2002) Surgical treatment for early osteoarthritis. Part II: allografts and concurrent procedures. Knee Surg Sports Traumatol Arthrosc 20(3):468–486CrossRef
13.
Zurück zum Zitat Gortz S, Bugbee WD (2007) Allografts in articular cartilage repair. Instr Course Lect 56:469–480PubMed Gortz S, Bugbee WD (2007) Allografts in articular cartilage repair. Instr Course Lect 56:469–480PubMed
14.
Zurück zum Zitat Gross AE, Aubin P, Cheah HK et al (2002) A fresh osteochondral allograft alternative. J Arthroplast 17(4):S50–S53CrossRef Gross AE, Aubin P, Cheah HK et al (2002) A fresh osteochondral allograft alternative. J Arthroplast 17(4):S50–S53CrossRef
15.
Zurück zum Zitat Hawker G, Wright J, Coyte P, Paul J, Dittus R, Croxford R, Katz B, Bombardier C, Heck D, Freund D (1998) Health-related quality of life after knee replacement. J Bone Joint Surg Am 80:163–173PubMed Hawker G, Wright J, Coyte P, Paul J, Dittus R, Croxford R, Katz B, Bombardier C, Heck D, Freund D (1998) Health-related quality of life after knee replacement. J Bone Joint Surg Am 80:163–173PubMed
17.
Zurück zum Zitat Kim CW, Jamali A, Tontz W Jr, Convery FR, Brage ME, Bugbee W (2002) Treatment of post-traumatic ankle arthrosis with bipolar tibiotalar osteochondral shell allografts. Foot Ankle Int 23(12):1091–1102PubMed Kim CW, Jamali A, Tontz W Jr, Convery FR, Brage ME, Bugbee W (2002) Treatment of post-traumatic ankle arthrosis with bipolar tibiotalar osteochondral shell allografts. Foot Ankle Int 23(12):1091–1102PubMed
18.
Zurück zum Zitat Langer F, Gross AE (1974) Immunogenicity of allograft articular cartilage. J Bone Joint Surg Am 56(2):297–304PubMed Langer F, Gross AE (1974) Immunogenicity of allograft articular cartilage. J Bone Joint Surg Am 56(2):297–304PubMed
19.
Zurück zum Zitat Langer F, Czitrom A, Pritzker KP, Gross AE (1975) The immunogenicity of fresh and frozen allogeneic bone. J Bone Joint Surg Am 57(2):216–220PubMed Langer F, Czitrom A, Pritzker KP, Gross AE (1975) The immunogenicity of fresh and frozen allogeneic bone. J Bone Joint Surg Am 57(2):216–220PubMed
20.
Zurück zum Zitat Locht RC, Gross AE, Langer F (1984) Late osteochondral allograft resurfacing for tibial plateau fractures. J Bone Joint Surg Am 66(3):328–335PubMed Locht RC, Gross AE, Langer F (1984) Late osteochondral allograft resurfacing for tibial plateau fractures. J Bone Joint Surg Am 66(3):328–335PubMed
21.
Zurück zum Zitat Lonner JH, Hershman S, Mont M, Lotke PA (2000) Total knee arthroplasty in patients 40 years of age and younger with osteoarthritis. Clin Orthop Relat Res 380:85–90PubMedCrossRef Lonner JH, Hershman S, Mont M, Lotke PA (2000) Total knee arthroplasty in patients 40 years of age and younger with osteoarthritis. Clin Orthop Relat Res 380:85–90PubMedCrossRef
22.
Zurück zum Zitat McDermott AG, Langer F, Pritzker KP, Gross AE (1985) Fresh small-fragment osteochondral allografts. Long-term follow-up study on first 100 cases. Clin Orthop Relat Res 197:96–102PubMed McDermott AG, Langer F, Pritzker KP, Gross AE (1985) Fresh small-fragment osteochondral allografts. Long-term follow-up study on first 100 cases. Clin Orthop Relat Res 197:96–102PubMed
23.
Zurück zum Zitat McGoveran BM, Pritzker KP, Shasha N, Price J, Gross AE (2002) Long-term chondrocyte viability in a fresh osteochondral allograft. J Knee Surg 15(2):97–100PubMed McGoveran BM, Pritzker KP, Shasha N, Price J, Gross AE (2002) Long-term chondrocyte viability in a fresh osteochondral allograft. J Knee Surg 15(2):97–100PubMed
24.
Zurück zum Zitat Minas T, Gomoll AH, Solhpour S, Rosenberger R, Probst C, Bryant T (2010) Autologous chondrocyte implantation for joint preservation in patients with early osteoarthritis. Clin Orthop Relat Res 468(1):147–157PubMedCentralPubMedCrossRef Minas T, Gomoll AH, Solhpour S, Rosenberger R, Probst C, Bryant T (2010) Autologous chondrocyte implantation for joint preservation in patients with early osteoarthritis. Clin Orthop Relat Res 468(1):147–157PubMedCentralPubMedCrossRef
25.
Zurück zum Zitat NIH Consensus Panel (2004) NIH Consensus Statement on total knee replacement December 8–10, 2003. J Bone Joint Surg Am 86-A:1328–1335 NIH Consensus Panel (2004) NIH Consensus Statement on total knee replacement December 8–10, 2003. J Bone Joint Surg Am 86-A:1328–1335
26.
Zurück zum Zitat Oakeshott RD, Farine I, Pritzker KP, Langer F, Gross AE (1988) A clinical and histologic analysis of failed fresh osteochondral allografts. Clin Orthop Relat Res 233:283–294PubMed Oakeshott RD, Farine I, Pritzker KP, Langer F, Gross AE (1988) A clinical and histologic analysis of failed fresh osteochondral allografts. Clin Orthop Relat Res 233:283–294PubMed
27.
Zurück zum Zitat Park DY, Chung DB et al (2006) Fresh osteochondral allografts for younger, active individuals with osteoarthrosis of the knee. International Cartilage Repair Society (ICRS) meeting, San Diego Park DY, Chung DB et al (2006) Fresh osteochondral allografts for younger, active individuals with osteoarthrosis of the knee. International Cartilage Repair Society (ICRS) meeting, San Diego
28.
Zurück zum Zitat Sgaglione NA, Chen E, Bert JM, Amendola A, Bugbee WD (2010) Current strategies for nonsurgical, arthroscopic, and minimally invasive surgical treatment of knee cartilage pathology. Instr Course Lect 59:157–180PubMed Sgaglione NA, Chen E, Bert JM, Amendola A, Bugbee WD (2010) Current strategies for nonsurgical, arthroscopic, and minimally invasive surgical treatment of knee cartilage pathology. Instr Course Lect 59:157–180PubMed
29.
Zurück zum Zitat Sheng PY, Konttinen L, Lehto M, Ogino D, Jamsen E, Nevalainen J, Pajamaki J, Halonen P, Konttinen YT (2006) Revision total knee arthroplasty: 1990 through 2002. A review of the Finnish arthroplasty registry. J Bone Joint Surg Am 88:1425–1430PubMedCrossRef Sheng PY, Konttinen L, Lehto M, Ogino D, Jamsen E, Nevalainen J, Pajamaki J, Halonen P, Konttinen YT (2006) Revision total knee arthroplasty: 1990 through 2002. A review of the Finnish arthroplasty registry. J Bone Joint Surg Am 88:1425–1430PubMedCrossRef
30.
Zurück zum Zitat Tontz WL Jr, Bugbee WD, Brage ME (2003) Use of allografts in the management of ankle arthritis. Foot Ankle Clin 8(2):361–373PubMedCrossRef Tontz WL Jr, Bugbee WD, Brage ME (2003) Use of allografts in the management of ankle arthritis. Foot Ankle Clin 8(2):361–373PubMedCrossRef
31.
Zurück zum Zitat Winters BS, Raikin SM (2013) The use of allograft in joint-preserving surgery for ankle osteochondral lesions and osteoarthritis. Foot Ankle Clin 18(3):529–542PubMedCrossRef Winters BS, Raikin SM (2013) The use of allograft in joint-preserving surgery for ankle osteochondral lesions and osteoarthritis. Foot Ankle Clin 18(3):529–542PubMedCrossRef
Metadaten
Titel
Failures in bipolar fresh osteochondral allograft for the treatment of end-stage knee osteoarthritis
verfasst von
S. Giannini
R. Buda
A. Ruffilli
G. Pagliazzi
A. Ensini
B. Grigolo
G. Desando
F. Vannini
Publikationsdatum
01.07.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 7/2015
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-014-2961-1

Weitere Artikel der Ausgabe 7/2015

Knee Surgery, Sports Traumatology, Arthroscopy 7/2015 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.