Erschienen in:
01.12.1999 | Paper Report
Fc?RIIA polymorphism and anti-C1q(CLR) in SLE
verfasst von:
Carrock Sewell
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
Einloggen, um Zugang zu erhalten
Excerpt
Two alleles of FcR?IIA, expressed on leukocytes and platelets, are recognised: H131, which binds IgG2 more strongly, and the R131 variant. R131 homozygotes cannot bind immune complexes in vitroand there may be an association with susceptibility to infection and autoimmune disease. Systemic lupus erythematosus (SLE) patients with autoantibodies to the collagenous region (CLR) of C1q develop nephritis. This study assessed the frequency of Fc?RIIA R131 homozygotes to determine if there is an association between Fc?RIIA polymorphism and antibodies to the CLR of C1q in patients with SLE. …