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Cancer and Metastasis Reviews

Erschienen in:

01.12.2010 | NON-THEMATIC REVIEW

Feedback regulation of proteasome gene expression and its implications in cancer therapy

verfasst von: Youming Xie

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 4/2010

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Abstract

Proteasomal protein degradation is one of the major regulatory mechanisms in the cell. Aberrant proteasome activity is directly related to the pathogenesis of many human diseases including cancers. How proteasome homeostasis is controlled is a fundamental question toward our understanding of proteasome dysregulation in cancer cells. The recent discovery of the Rpn4-proteasome negative feedback circuit provides mechanistic insight into the regulation of proteasome gene expression. This finding also has important implications in cancer therapy that uses small molecule inhibitors to target the proteasome.

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Titel: Feedback regulation of proteasome gene expression and its implications in cancer therapy
verfasst von: Youming Xie
Publikationsdatum: 01.12.2010
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 4/2010
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-010-9255-y

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Springer Medizin

Feedback regulation of proteasome gene expression and its implications in cancer therapy

Abstract

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