Enteroviruses commonly infect children, with syndromes ranging from asymptomatic infection and benign illness, aseptic meningitis, to severe life-threatening disease[
1]. Some newborns develop severe disease in the first 2 weeks of life and long-term sequelae may occur among survivors. Risk factors and clinical features associated with severe disease involve early onset of illness within the first few days of life[
2]. Enteroviruses include more than 260 different types of pathogens including polioviruses, echoviruses, coxsackieviruses and rhinoviruses. Illness encompasses a wide spectrum of symptoms from mild fever to upper respiratory tract infections, rash, aseptic meningitis, severe myocarditis, encephalitis, and paralytic disorders. Enteroviruses are transmitted primarily via a fecal-oral route and respiratory aerosols[
3]. Coxsackie A viruses have been associated with mild clinical symptoms such as flu-like illness and meningitis and hand-foot-and-mouth disease. By contrast, coxsackie B viruses may cause pancreatitis, hepatitis, aseptic meningitis, myocarditis/pericarditis, and type 1 diabetes as well as neonatal sepsis[
4‐
6]. In 2006, six neonates with enteroviral meningoencephalitis were described[
7]. Five babies presented with prolonged seizures, and one presented with systemic enteroviral disease. Cranial ultrasonography showed increased echogenicity in the periventricular white matter, and magnetic resonance imaging (MRI) confirmed mild to severe white matter damage in all babies. Recent case reports describe a full-term neonate with coxsackie B2 infection presenting with meningoencephalitis with seizures, and lesions in the white matter, and a fatal case of newborn coxsackie B1 virus infection with apnoeic episodes and desaturations[
8,
9]. In these cases, an electroencephalogram (EEG) revealed multifocal epileptiform discharges, and a cranial MRI showed multiple lesions, respectively.