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Neurological Sciences

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02.09.2022 | Review Article

Frailty and cognitive impairment in Parkinson’s disease: a systematic review

verfasst von: M. C. Sousa-Fraguas, G. Rodríguez-Fuentes, N. M. Conejo

Erschienen in: Neurological Sciences | Ausgabe 12/2022

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Abstract

Background

Frailty can lead to increased vulnerability in older people and patients with Parkinson’s disease (pwPD) and worsen their health conditions. These patients can also develop cognitive function impairment. The objective is to analyze whether there is a relationship between frailty and cognitive impairment in pwPD, and to find out which instruments to use for its evaluation.

Methods

Publications were searched in PubMed, Medline, Web of Science, Cinalh, Cochrane Library, Embase, Phycinfo, and Scopus. The results were measured with the instruments that are used to assess frailty and cognitive impairment, and analyze their relationship.

Results

Two hundred seventy-one articles were identified, of which 12 met the inclusion criteria. All studies assessed frailty and cognitive function in pwPD. Five studies analyzed the relationship between frailty and cognitive impairment. The most used instruments were the Fried scale followed by the Clinical Frailty Scale (CFS) for frailty. Cognitive impairment was mostly evaluated with the Mini-Mental State Examination and the Montreal Cognitive Assessment. The prevalence data ranged from 20.2 to 51.5% with the Fried scale and from 35.6 to 83.9% with the CFS. Cognitive impairment was present in 15 to 45.2% of the pwPD.

Conclusion

Analysis of the included studies shows a relationship between frailty and cognitive impairment in pwPD. There was significant variability in the application of the scales used, which influences the prevalence data. More observational and experimental studies are needed to provide more evidence on this association and to determine which is the optimal tool to identify frailty in pwPD using multidimensional scales.

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Simon DK, Tanner CM, Brundin P (2020) Parkinson disease epidemiology, pathology, genetics, and pathophysiology. Clin Geriatr Med 36:1–12. https://doi.org/10.1016/j.cger.2019.08.002CrossRefPubMed

Balestrino R, Schapira AHV (2020) Parkinson disease. Eur J Neurol 27:27–42. https://doi.org/10.1111/ene.14108CrossRefPubMed

Lee A, Gilbert RM (2016) Epidemiology of Parkinson disease. Neurol Clin 34:955–965. https://doi.org/10.1016/j.ncl.2016.06.012CrossRefPubMed

Bamford A, Henderson EJ (2021) Parkinson’s disease in older people. Med (United Kingdom) 49:56–61. https://doi.org/10.1016/j.mpmed.2020.10.008CrossRef

Raza C, Anjum R, Shakeel NUA (2019) Parkinson’s disease: mechanisms, translational models and management strategies. Life Sci 226:77–90. https://doi.org/10.1016/j.lfs.2019.03.057CrossRefPubMed

Menozzi E, Macnaughtan J, Schapira AHV (2021) The gut-brain axis and Parkinson disease: clinical and pathogenetic relevance. Ann Med 53:611–625. https://doi.org/10.1080/07853890.2021.1890330CrossRefPubMedPubMedCentral

Cryan JF, O’Riordan KJ, Sandhu K et al (2020) The gut microbiome in neurological disorders. Lancet Neurol 19:179–194. https://doi.org/10.1016/s1474-4422(19)30356-4CrossRefPubMed

Morley JE, Vellas B, van Kan GA et al (2013) Frailty consensus: a call to action. J Am Med Dir Assoc 14:392–397. https://doi.org/10.1016/j.jamda.2013.03.022CrossRefPubMedPubMedCentral

Satake S, Arai H (2020) Chapter 1 Frailty: definition, diagnosis, epidemiology. Geriatr Gerontol Int 20:7–13. https://doi.org/10.1111/ggi.13830CrossRefPubMed

10.

He B, Ma Y, Wang C et al (2019) Prevalence and risk factors for frailty among community-dwelling older people in china: a systematic review and meta-analysis. J Nutr Heal Aging 23:442–450. https://doi.org/10.1007/s12603-019-1179-9CrossRef

11.

Verlaan S, Ligthart-Melis GC, Wijers SLJ et al (2017) High prevalence of physical frailty among community-dwelling malnourished older adults-a systematic review and meta-analysis. J Am Med Dir Assoc 18:374–382. https://doi.org/10.1016/j.jamda.2016.12.074CrossRefPubMed

12.

Collard RM, Boter H, Schoevers RA, Oude Voshaar RC (2012) Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc 60:1487–1492. https://doi.org/10.1111/j.1532-5415.2012.04054.xCrossRefPubMed

13.

Chiang PL, Chen YS, Lin AW (2019) Altered body composition of psoas and thigh muscles in relation to frailty and severity of Parkinson’s disease. Int J Env Res Public Heal 16. https://doi.org/10.3390/ijerph16193667

14.

Ahmed NN, Sherman SJ, VanWyck D (2008) Frailty in Parkinson’s disease and its clinical implications. Park Relat Disord 14:334–337. https://doi.org/10.1016/j.parkreldis.2007.10.004CrossRef

15.

Roland KP, Jakobi JM, Jones GR, Powell C (2012) Quality of life as a determinant of frailty phenotype in community-dwelling persons with Parkinson’s disease. J Am Geriatr Soc 60:590–592. https://doi.org/10.1111/j.1532-5415.2011.03862.xCrossRefPubMed

16.

Roland KP, Cornett KM, Theou O et al (2012) Concurrence of frailty and Parkinson’s disease. J Frailty Aging 1:123–127. https://doi.org/10.14283/jfa.2012.20CrossRefPubMed

17.

Fried LP, Tangen CM, Walston J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–M156. https://doi.org/10.1093/gerona/56.3.M146CrossRefPubMed

18.

Rockwood K, Song X, MacKnight C et al (2005) A global clinical measure of fitness and frailty in elderly people. CMAJ 173:489–495. https://doi.org/10.1503/cmaj.050051CrossRefPubMedPubMedCentral

19.

Aarsland D, Creese B, Politis M et al (2017) Cognitive decline in Parkinson disease. Nat Rev Neurol 13:217–231. https://doi.org/10.1038/nrneurol.2017.27CrossRefPubMedPubMedCentral

20.

Tangalos EG, Petersen RC (2018) Mild cognitive impairment in geriatrics. Clin Geriatr Med 34:563–589. https://doi.org/10.1016/j.cger.2018.06.005CrossRefPubMed

21.

Petersen RC, Lopez O, Armstrong MJ et al (2018) Practice guideline update summary: mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 90:126–135. https://doi.org/10.1212/wnl.0000000000004826CrossRefPubMedPubMedCentral

22.

Baiano C, Barone P, Trojano L, Santangelo G (2020) Prevalence and clinical aspects of mild cognitive impairment in Parkinson’s disease: a meta-analysis. Mov Disord 35:45–54. https://doi.org/10.1002/mds.27902CrossRefPubMed

23.

Davis AA, Racette B (2016) Parkinson disease and cognitive impairment: five new things. Neurol Clin Pr 6:452–458. https://doi.org/10.1212/cpj.0000000000000285CrossRef

24.

Mello BH, Lenardt MH, Moraes DC et al (2021) Cognitive impairment and physical frailty in older adults in secondary health care. Rev Esc Enferm USP 55:e03687. https://doi.org/10.1590/s1980-220x2019029803687CrossRefPubMed

25.

Yuan Y, Lapane KL, Tjia J et al (2021) Physical frailty and cognitive impairment in older adults in United States nursing homes. Dement Geriatr Cogn Disord 50:60–67. https://doi.org/10.1159/000515140CrossRefPubMed

26.

Sourial N, Bergman H, Karunananthan S et al (2012) Contribution of frailty markers in explaining differences among individuals in five samples of older persons. J Gerontol A Biol Sci Med Sci 67:1197–1204. https://doi.org/10.1093/gerona/gls084CrossRefPubMedPubMedCentral

27.

Sourial N, Wolfson C, Bergman H et al (2010) A correspondence analysis revealed frailty deficits aggregate and are multidimensional. J Clin Epidemiol 63:647–654. https://doi.org/10.1016/j.jclinepi.2009.08.007CrossRefPubMed

28.

Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71CrossRefPubMedPubMedCentral

29.

Richardson WS, Wilson MC, Nishikawa J, Hayward RS (1995) The well-built clinical question: a key to evidence-based decisions. ACP J Club 123:A12–A13CrossRefPubMed

30.

Wells G, Shea B, O’Connell D, et al NOS for assessing quality of nonrandomised studies. https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 1 Sep 2021

31.

Smith N, Brennan L, Gaunt DM et al (2019) Frailty in Parkinson’s disease: a systematic review. J Park Dis 9:517–524. https://doi.org/10.3233/jpd-191604CrossRef

32.

Herzog R, Álvarez-Pasquin MJ, Díaz C et al (2013) Are healthcare workers’ intentions to vaccinate related to their knowledge, beliefs and attitudes? Syst Rev BMC Publ Health 13:154. https://doi.org/10.1186/1471-2458-13-154CrossRef

33.

Belvisi D, Canevelli M, Costanzo M, et al (2021) The role of frailty in Parkinson’s disease: a cross-sectional study. J Neurol. https://doi.org/10.1007/s00415-021-10873-3

34.

Bernhard FP, Sartor J, Bettecken K, et al (2018) Wearables for gait and balance assessment in the neurological ward - study design and first results of a prospective cross-sectional feasibility study with 384 inpatients. BMC Neurol 18. https://doi.org/10.1186/s12883-018-1111-7

35.

Chen YS, Chen HL, Lu CH et al (2019) Reduced lateral occipital gray matter volume is associated with physical frailty and cognitive impairment in Parkinson’s disease. Eur Radiol 29:2659–2668. https://doi.org/10.1007/s00330-018-5855-7CrossRefPubMed

36.

Lawson RA, Richardson SJ, Yarnall AJ et al (2020) Identifying delirium in Parkinson disease: a pilot study. Int J Geriatr Psychiatry 35:547–552. https://doi.org/10.1002/gps.5270CrossRefPubMedPubMedCentral

37.

Lin WC, Huang YC, Leong CP, et al (2019) Associations between cognitive functions and physical frailty in patients with Parkinson’s disease. Front Aging Neurosci 11. https://doi.org/10.3389/fnagi.2019.00283

38.

Ntanasi E, Maraki M, Yannakoulia M et al (2021) Frailty and prodromal Parkinson’s disease: results from the HELIAD study. J Gerontol A Biol Sci Med Sci 76:622–629. https://doi.org/10.1093/gerona/glaa191CrossRefPubMed

39.

Özer FF, Akin S, Gültekin M et al (2021) Frailty in patients with Parkinson’s disease: associations with disability and timed up and go. Noro Psikiyatr Ars 58:206–212. https://doi.org/10.29399/npa.23444CrossRefPubMed

40.

Peball M, Mahlknecht P, Werkmann M et al (2019) Prevalence and associated factors of sarcopenia and frailty in Parkinson’s disease: a cross-sectional study. Gerontology 65:216–228. https://doi.org/10.1159/000492572CrossRefPubMed

41.

Smith N, Gaunt DM, Whone A et al (2021) The association between frailty and Parkinson’s disease in the ReSPOnD Trial. Can Geriatr J 24:22–25. https://doi.org/10.5770/cgj.24.437CrossRefPubMedPubMedCentral

42.

Tan AH, Chong CW, Lim SY et al (2021) Gut microbial ecosystem in Parkinson disease: new clinicobiological insights from multi-omics. Ann Neurol 89:546–559. https://doi.org/10.1002/ana.25982CrossRefPubMed

43.

Torsney KM, Romero-Ortuno R (2018) The Clinical Frailty Scale predicts inpatient mortality in older hospitalised patients with idiopathic Parkinson’s disease. J R Coll Physicians Edinb 48:103–107. https://doi.org/10.4997/jrcpe.2018.201CrossRefPubMed

44.

Wojszel ZB, Kasiukiewicz A, Magnuszewski L (2019) Health and functional determinants of orthostatic hypotension in geriatric ward patients: a retrospective cross sectional cohort study. J Nutr Heal Aging 23:509–517. https://doi.org/10.1007/s12603-019-1201-2CrossRef

45.

Rockwood K, Mitnitski A (2007) Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci 62:722–727. https://doi.org/10.1093/gerona/62.7.722CrossRefPubMed

46.

Clegg A, Young J, Iliffe S et al (2013) Frailty in elderly people. Lancet 381:752–762. https://doi.org/10.1016/S0140-6736(12)62167-9CrossRefPubMed

47.

Searle SD, Mitnitski A, Gahbauer EA et al (2008) A standard procedure for creating a frailty index. BMC Geriatr 8:24. https://doi.org/10.1186/1471-2318-8-24CrossRefPubMedPubMedCentral

48.

Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39:142–148. https://doi.org/10.1111/j.1532-5415.1991.tb01616.xCrossRefPubMed

49.

Bartoli M, Palermo S, Cipriani GE, Amanzio M (2020) A possible association between executive dysfunction and frailty in patients with neurocognitive disorders. Front Psychol 11. https://doi.org/10.3389/fpsyg.2020.554307

50.

Borges MK, Canevelli M, Cesari M, Aprahamian I (2019) Frailty as a predictor of cognitive disorders: a systematic review and meta-analysis. Front Med 6:26. https://doi.org/10.3389/fmed.2019.00026CrossRef

51.

Kiiti Borges M, de Castro Oiring, Cezar N, Silva Santos Siqueira A et al (2019) The relationship between physical frailty and mild cognitive impairment in the elderly: a systematic review. J Frailty Aging 8:192–197. https://doi.org/10.14283/jfa.2019.29CrossRefPubMed

52.

Boyle PA, Buchman AS, Wilson RS et al (2010) Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc 58:248–255. https://doi.org/10.1111/j.1532-5415.2009.02671.xCrossRefPubMedPubMedCentral

53.

Gross AL, Xue QL, Bandeen-Roche K et al (2016) Declines and impairment in executive function predict onset of physical frailty. J Gerontol A Biol Sci Med Sci 71:1624–1630. https://doi.org/10.1093/gerona/glw067CrossRefPubMedPubMedCentral

54.

Rosado-Artalejo C, Carnicero JA, Losa-Reyna J et al (2017) Cognitive performance across 3 frailty phenotypes: Toledo study for healthy aging. J Am Med Dir Assoc 18:785–790. https://doi.org/10.1016/j.jamda.2017.04.008CrossRefPubMed

55.

Macuco CR, Batistoni SS, Lopes A et al (2012) Mini-Mental State Examination performance in frail, pre-frail, and non-frail community dwelling older adults in Ermelino Matarazzo, São Paulo, Brazil. Int Psychogeriatr 24:1725–1731. https://doi.org/10.1017/s1041610212000907CrossRefPubMed

56.

Robertson DA, Savva GM, Coen RF, Kenny RA (2014) Cognitive function in the prefrailty and frailty syndrome. J Am Geriatr Soc 62:2118–2124. https://doi.org/10.1111/jgs.13111CrossRefPubMed

57.

Ma L, Chan P (2020) Understanding the physiological links between physical frailty and cognitive decline. Aging Dis 11:405–418. https://doi.org/10.14336/ad.2019.0521CrossRefPubMedPubMedCentral

58.

McMillan JM, Michalchuk Q, Goodarzi Z (2021) Frailty in Parkinson’s disease: a systematic review and meta-analysis. Clin Park Relat Disord 4:100095. https://doi.org/10.1016/j.prdoa.2021.100095CrossRefPubMedPubMedCentral

59.

Soysal P, Veronese N, Thompson T et al (2017) Relationship between depression and frailty in older adults: a systematic review and meta-analysis. Ageing Res Rev 36:78–87. https://doi.org/10.1016/j.arr.2017.03.005CrossRefPubMed

60.

Abraham DS, Pham Nguyen TP, Willis AW (2021) Claims-based frailty and outcomes: applying an aging measure to older adults with Parkinson’s disease. Mov Disord 36:1871–1878. https://doi.org/10.1002/mds.28561CrossRefPubMedPubMedCentral

61.

Vetrano DL, Pisciotta MS, Laudisio A et al (2018) Sarcopenia in Parkinson disease: comparison of different criteria and association with disease severity. J Am Med Dir Assoc 19:523–527. https://doi.org/10.1016/j.jamda.2017.12.005CrossRefPubMed

62.

Ebina J, Ebihara S, Kano O (2022) Similarities, differences and overlaps between frailty and Parkinson’s disease. Geriatr Gerontol Int 22:259–270. https://doi.org/10.1111/ggi.14362CrossRefPubMed

63.

Di Sabatino A, Lenti MV, Cammalleri L et al (2018) Frailty and the gut. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver 50:533–541. https://doi.org/10.1016/j.dld.2018.03.010CrossRef

64.

Hoogendijk EO, Afilalo J, Ensrud KE et al (2019) Frailty: implications for clinical practice and public health. Lancet 394:1365–1375. https://doi.org/10.1016/s0140-6736(19)31786-6CrossRefPubMed

65.

Junius-Walker U, Onder G, Soleymani D et al (2018) The essence of frailty: a systematic review and qualitative synthesis on frailty concepts and definitions. Eur J Intern Med 56:3–10. https://doi.org/10.1016/j.ejim.2018.04.023CrossRefPubMed

66.

Sezgin D, Liew A, O’Donovan MR, O’Caoimh R (2020) Pre-frailty as a multi-dimensional construct: a systematic review of definitions in the scientific literature. Geriatr Nurs 41:139–146. https://doi.org/10.1016/j.gerinurse.2019.08.004CrossRefPubMed

67.

Clegg A, Rogers L, Young J (2015) Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review. Age Ageing 44:148–152. https://doi.org/10.1093/ageing/afu157CrossRefPubMed

68.

Apostolo J, Cooke R, Bobrowicz-Campos E et al (2017) Predicting risk and outcomes for frail older adults: an umbrella review of frailty screening tools. JBI Database Syst Rev Implement Rep 15:1154–1208. https://doi.org/10.11124/JBISRIR-2016-003018CrossRef

69.

Goldman JG, Sieg E (2020) Cognitive impairment and dementia in Parkinson disease. Clin Geriatr Med 36:365–377. https://doi.org/10.1016/j.cger.2020.01.001CrossRefPubMed

70.

Roheger M, Kalbe E, Liepelt-Scarfone I (2018) Progression of cognitive decline in Parkinson’s disease. J Park Dis 8:183–193. https://doi.org/10.3233/jpd-181306CrossRef

71.

Skorvanek M, Goldman JG, Jahanshahi M et al (2018) Global scales for cognitive screening in Parkinson’s disease: critique and recommendations. Mov Disord 33:208–218. https://doi.org/10.1002/mds.27233CrossRefPubMed

Titel: Frailty and cognitive impairment in Parkinson’s disease: a systematic review
verfasst von: M. C. Sousa-Fraguas
G. Rodríguez-Fuentes
N. M. Conejo
Publikationsdatum: 02.09.2022
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 12/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06347-7

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