nach oben

Neuropsychology Review

Erschienen in:

01.06.2011 | Review

From Research to Practice: An Integrative Framework for the Development of Interventions for Children with Fetal Alcohol Spectrum Disorders

verfasst von: Piyadasa W. Kodituwakku, E. Louise Kodituwakku

Erschienen in: Neuropsychology Review | Ausgabe 2/2011

Einloggen, um Zugang zu erhalten

Abstract

Since fetal alcohol syndrome was first described over 35 years ago, considerable progress has been made in the delineation of the neurocognitive profile in children with prenatal alcohol exposure. Preclinical investigators have made impressive strides in elucidating the mechanisms of alcohol teratogenesis and in testing the effectiveness of pharmacological agents and dietary supplementation in the amelioration of alcohol-induced deficits. Despite these advances, only limited progress has been made in the development of evidence-based comprehensive interventions for functional impairment in alcohol-exposed children. Having performed a search in PubMed and PsycINFO using key words, interventions, treatment, fetal alcohol syndrome, prenatal alcohol exposure, and fetal alcohol spectrum disorders, we found only 12 papers on empirically-based interventions. Only two of these interventions had been replicated and none met the criteria of “well-established,” as defined by Chambless and Hollon (Journal of Consulting and Clinical Psychology 66(1):7–18, 1998). There has been only limited cross-fertilization of ideas between preclinical and clinical research with regard to the development of interventions. Therefore, we propose a framework that allows integrating data from preclinical and clinical investigations to develop comprehensive intervention programs for children with fetal alcohol spectrum disorders. This framework underscores the importance of multi-level evaluations and interventions.

Adnams, C. M., Sorour, P., Kalberg, W. O., Kodituwakku, P., Perold, M. D., Kotze, A., et al. (2007). Language and literacy outcomes from a pilot intervention study for children with fetal alcohol spectrum disorders in South Africa. Alcohol, 41(6), 403–414.PubMedCrossRef

Albers, E. M., Riksen-Walraven, J. M., Sweep, F. C., & de Weerth, C. (2008). Maternal behavior predicts infant cortisol recovery from a mild everyday stressor. Journal of Child Psychology and Psychiatry, 49(1), 97–103.PubMedCrossRef

Astley, S. B. (2004). Diagnostic guide for fetal alcohol spectrum disorders (3rd ed.). Seattle: University of Washingston Publication Services.

Becker, M., Warr-Leeper, G. A., & Leeper, H. A., Jr. (1990). Fetal alcohol syndrome: a description of oral motor, articulatory, short-term memory, grammatical, and semantic abilities. Journal of Communication Disorders, 23(2), 97–124.PubMedCrossRef

Berman, R. F., Hannigan, J. H., Sperry, M. A., & Zajac, C. S. (1996). Prenatal alcohol exposure and the effects of environmental enrichment on hippocampal dendritic spine density. Alcohol, 13(2), 209–216.PubMedCrossRef

Bertrand, J. (2009). Interventions for children with fetal alcohol spectrum disorders (FASDs): overview of findings for five innovative research projects. Research in Developmetal Disabilities, 30(5), 986–1006.CrossRef

Blair, C., & Diamond, A. (2008). Biological processes in prevention and intervention: the promotion of self-regulation as a means of preventing school failure. Development and Psychopatholgy, 20(3), 899–911.

Blair, C., & Razza, R. P. (2007). Relating effortful control, executive function, and false belief understanding to emerging math and literacy ability in kindergarten. Child Development, 78(2), 647–663.PubMedCrossRef

Bodrova, E., & Leong, D. J. (2007). Tools of the mind: The Vygotskian approach to early childhood education (2nd ed.). New York: Merrill/Prentice Hall.

Burd, L., Klug, M. G., Martsolf, J. T., & Kerbeshian, J. (2003). Fetal alcohol syndrome: neuropsychiatric phenomics. Neurotoxicology and Teratology, 25(6), 697–705.PubMedCrossRef

Burden, M. J., Jacobson, S. W., & Jacobson, J. L. (2005). Relation of prenatal alcohol exposure to cognitive processing speed and efficiency in childhood. Alcoholism, Clinical and Experimental Research, 29(8), 1473–1483.PubMedCrossRef

Busciglio, J., Pelsman, A., Helguera, P., Ashur-Fabian, O., Pinhasov, A., Brenneman, D. E., et al. (2007). NAP and ADNF-9 protect normal and Down’s syndrome cortical neurons from oxidative damage and apoptosis. Current Pharmceutical Design, 13(11), 1091–1098.CrossRef

Campbell, D. T., & Stanley, J. C. (1963). Experimental and quasi-experimental designs for research. Chicago: Rand McNally.

Carmichael Olson, H., Feldman, J. J., Streissguth, A. P., Sampson, P. D., & Bookstein, F. L. (1998). Neuropsychological deficits in adolescents with fetal alcohol syndrome: clinical findings. Alcoholism, Clinical and Experimental Research, 22(9), 1998–2012.

Carmichael Olson, H., Oti, R., Gelo, J., & Beck, S. (2009). “Family matters:” fetal alcohol spectrum disorders and the family. Devevelopmental Disabilities Research Reviews, 15(3), 235–249.CrossRef

Chambless, D. L., & Hollon, S. D. (1998). Defining empirically supported therapies. Journal of Consulting and Clinical Psychology, 66(1), 7–18.PubMedCrossRef

Choi, I. Y., Allan, A. M., & Cunningham, L. A. (2005). Moderate fetal alcohol exposure impairs the neurogenic response to an enriched environment in adult mice. Alcoholism, Clinical and Experimental Research, 29(11), 2053–2062.PubMedCrossRef

Cohen-Kerem, R., & Koren, G. (2003). Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implications to humans. Neurotoxicology and Teratology, 25(1), 1–9.PubMedCrossRef

Coles, C. D., Platzman, K. A., Raskind-Hood, C. L., Brown, R. T., Falek, A., & Smith, I. E. (1997). A comparison of children affected by prenatal alcohol exposure and attention deficit, hyperactivity disorder. Alcoholism, Clinical and Experimental Research, 21(1), 150–161.PubMedCrossRef

Coles, C. D., Strickland, D. C., Padgett, L., & Bellmoff, L. (2007). Games that “work”: using computer games to teach alcohol-affected children about fire and street safety. Research in Developmental Disabilities, 28(5), 518–530.PubMedCrossRef

Coles, C. D., Kable, J. A., & Taddeo, E. (2009). Math performance and behavior problems in children affected by prenatal alcohol exposure: intervention and follow-up. Journal of Developmental and Behavioral Pediatrics, 30(1), 7–15.PubMedCrossRef

Connor, P. D., Sampson, P. D., Streissguth, A. P., Bookstein, F. L., & Barr, H. M. (2006). Effects of prenatal alcohol exposure on fine motor coordination and balance: a study of two adult samples. Neuropsychologia, 44(5), 744–751.PubMedCrossRef

Conry, J. (1990). Neuropsychological deficits in fetal alcohol syndrome and fetal alcohol effects. Alcoholism, Clinical and Experimental Research, 14(5), 650–655.PubMedCrossRef

Crocker, N., Nguyen, T. T., & Mattson, S. N. (2011). Review of neuropsychological and behavioral effects of heavy prenatal alcohol exposure. Neuropsychology Review, 21(2), in press.

Deng, W., Aimone, J. B., & Gage, F. H. (2010). New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nature Reviews. Neuroscience, 11(5), 339–350.PubMedCrossRef

Diamond, A., Barnett, W. S., Thomas, J., & Munro, S. (2007). Preschool program improves cognitive control. Science, 318(5855), 1387–1388.PubMedCrossRef

Doig, J., McLennan, J. D., & Gibbard, W. B. (2008). Medication effects on symptoms of attention-deficit/hyperactivity disorder in children with fetal alcohol spectrum disorder. Journal of Child and Adolescent Psychopharmacology, 18(4), 365–371.PubMedCrossRef

Druse, M. J. (1996). Neurotranmitter function: changes associated with in utero alcohol exposure. In E. L. Abel (Ed.), Fetal alcohol syndrome: From mechanisms to prevention (pp. 171–190). Boca Raton: CRC.

Druse, M. J., Kuo, A., & Tajuddin, N. (1991). Effects of in utero ethanol exposure on the developing serotonergic system. Alcoholism, Clinical and Experimental Research, 15(4), 678–684.PubMedCrossRef

Druse, M. J., Tajuddin, N. F., Gillespie, R. A., Dickson, E., Atieh, M., Pietrzak, C. A., et al. (2004). The serotonin-1A agonist ipsapirone prevents ethanol-associated death of total rhombencephalic neurons and prevents the reduction of fetal serotonin neurons. Brain Research. Developmental Brain Research, 150(2), 79–88.PubMedCrossRef

Eriksen, J. L., & Druse, M. J. (2001). Astrocyte-mediated trophic support of developing serotonin neurons: effects of ethanol, buspirone, and S100B. Brain Research. Developmental Brain Research, 131(1–2), 9–15.PubMedCrossRef

Eyberg, S. M., & Matarazzo, R. G. (1980). Training parents as therapists: a comparison between individual parent–child interaction training and parent group didactic training. Journal of Clinical Psychology, 36(2), 492–499.PubMed

Eyeberg, S. M., & Boggs, S. R. (1998). Parent–child interaction therapy for oppositional preschoolers. In C. E. Shaefer & J. M. Briesmeister (Eds.), Handbook of parent training: parents as co-therapists chidlren’s behavior problems (2nd ed., pp. 61–97). New York: Wiley.

Fiore, M., Laviola, G., Aloe, L., di Fausto, V., Mancinelli, R., & Ceccanti, M. (2009). Early exposure to ethanol but not red wine at the same alcohol concentration induces behavioral and brain neurotrophin alterations in young and adult mice. Neurotoxicology, 30(1), 59–71.PubMedCrossRef

Fossella, J., Fan, J., Liu, X., Guise, K., Brocki, K., Hof, P. R., et al. (2008). Provisional hypotheses for the molecular genetics of cognitive development: imaging genetic pathways in the anterior cingulate cortex. Biological Psychology, 79(1), 23–29.PubMedCrossRef

Frankel, F. (2005). Parent-assisted children’s friendship training. In E. D. Hibbs & P. S. Jensen (Eds.), Psychosocial treatments for child and adolescent disorders: Empirically based approaches (pp. 693–715). Washington: American Psychological Association.

Frankel, F., Paley, B., Marquardt, R., & O’Connor, M. (2006). Stimulants, neuroleptics, and children’s friendship training for children with fetal alcohol spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 16(6), 777–789.PubMedCrossRef

Gabriel, K. I., Yu, W., Ellis, L., & Weinberg, J. (2000). Postnatal handling does not attenuate hypothalamic-pituitary-adrenal hyperresponsiveness after prenatal ethanol exposure. Alcoholism, Clinical and Experimental Research, 24(10), 1566–1574.PubMedCrossRef

Gabriel, K. I., Johnston, S., & Weinberg, J. (2002). Prenatal ethanol exposure and spatial navigation: effects of postnatal handling and aging. Developmetal Psychobiology, 40(4), 345–357.CrossRef

Gage, F. H. (2000). Mammalian neural stem cells. Science, 287(5457), 1433–1438.PubMedCrossRef

Gage, F. H., & Verma, I. M. (2003). Stem cells at the dawn of the 21st century. Proceedings of the National Academy of Sciences of the United States of America, 100(Supplement 1), 11817–11818.PubMedCrossRef

Goodlett, C. R., & Horn, K. H. (2001). Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Research and Health: The Journal of the National Institute on Alcohol Absue and Alcoholism, 25(3), 175–184.

Goodlett, C. R., Horn, K. H., & Zhou, F. C. (2005). Alcohol teratogenesis: mechanisms of damage and strategies for intervention. Experimental Biology and Medicine, 230(6), 394–406.PubMed

Green, C. R., Mihic, A. M., Nikkel, S. M., Stade, B. C., Rasmussen, C., Munoz, D. P., et al. (2009). Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB). Journal of Child Psychology and Psychiatry, and Allied Disciplines, 50(6), 688–697.PubMed

Greenbaum, R. L., Stevens, S. A., Nash, K., Koren, G., & Rovet, J. (2009). Social cognitive and emotion processing abilities of children with fetal alcohol spectrum disorders: a comparison with attention deficit hyperactivity disorder. Alcoholism, Clinical and Experimental Research, 33(10), 1656–1670.PubMedCrossRef

Greenough, W. T. (1976). Enduring brain effects of differential experience and training. In M. R. Rosenzweig & E. L. Bennett (Eds.), Neural mechanisms of learning and memory (pp. 255–278). Cambridge: MIT.

Guerri, C. (2002). Mechanisms involved in central nervous system dysfunctions induced by prenatal ethanol exposure. Neurotoxicity Research, 4(4), 327–335.PubMedCrossRef

Guerri, C., Pascual, M., Garcia-Minguilán, M. C., Charness, M. E., Wilkemeyer, M. F., Klintsova, A. Y., et al. (2005). Fetal alcohol effects: potential trreatments from basic science. Alcoholism, Clinical and Experimental Research, 29(6), 1074–1079.CrossRef

Guralnick, M. J. (1998). Effectiveness of early intervention for vulnerable children: a developmental perspective. American Journal of Mental Retardation, 102(4), 319–345.PubMed

Hannigan, J. H., & Randall, S. (1996). Behavioral phramacology in animals exposed prenatally to alcohol. In E. L. Abel (Ed.), Fetal alcohol syndrome: From mechanism to prevention (pp. 191–213). New York: CRC.

Hannigan, J. H., Berman, R. F., & Zajac, C. S. (1993). Environmental enrichment and the behavioral effects of prenatal exposure to alcohol in rats. Neurotoxicology and Teratology, 15(4), 261–266.PubMedCrossRef

Hannigan, J. H., O’Leary-Moore, S. K., & Berman, R. F. (2007). Postnatal environmental or experimental amelioration of neurobehavioral effects of perinatal alcohol exposure in rats. Neuroscience and Biobehavavioral Reviews, 31, 202–211.CrossRef

Hans, S. L. (1999). Demographic and psychosocial characteristics of substance-abusing pregnant women. Clinics in Perinatology, 26(1), 55–74.PubMed

Hebb, D. O. (1947). The effects of early experience on problem solving in maturity. The American Psychologist, 2, 306–307.

Jacobson, N. S., & Christensen, A. (1996). Studying the effectiveness of psychotherapy. How well can clinical trials do the job? The American Psychologist, 51(10), 1031–1039.PubMedCrossRef

Jones, K. L., & Smith, D. W. (1973). Recognition of the fetal alcohol syndrome in early infancy. Lancet, 2(7836), 999–1001.CrossRef

Kable, J. A., Coles, C. D., & Taddeo, E. (2007). Socio-cognitive habilitation using the math interactive learning experience program for alcohol-affected children. Alcoholism, Clinical and Experimental Research, 31(8), 1425–1434.PubMedCrossRef

Kalberg, W. O., & Buckley, D. (2007). FASD: what types of intervention and rehabilitation are useful? Neuroscience and Biobehavioral Reviews, 31, 278–285.PubMedCrossRef

Karmiloff-Smith, A. (2009). Nativism versus neuroconstructivism: rethinking the study of developmental disorders. Developmental Psychology, 45(1), 56–63.PubMedCrossRef

Karmiloff-Smith, A., & Thomas, M. (2003). What can developmental disorders tell us about the neurocomputational constraints that shape development? The case of Williams syndrome. Development and Psychopathology, 15(4), 969–990.PubMed

Kazdin, A. E. (1999). Current (lack of) status of theory in child and adolescent psychotherapy research. Journal of Clinical Child Psychology, 28(4), 533–543.PubMed

Kazdin, A. E. (2002). Research design in clinical psychology (4th ed.). Boston: Allyn & Bacon.

Keil, V., Paley, B., Frankel, F., & O’Connor, M. J. (2010). Impact of a social skills intervention on the hostile attributions of children with prenatal alcohol exposure. Alcoholism, Clinical and Experimental Research, 34(2), 231–241.PubMedCrossRef

Klintsova, A. Y., Matthews, J. T., Goodlett, C. R., Napper, R. M., & Greenough, W. T. (1997). Therapeutic motor training increases parallel fiber synapse number per Purkinje neuron in cerebellar cortex of rats given postnatal binge alcohol exposure: preliminary report. Alcoholism, Clinical and Experimental Research, 21(7), 1257–1263.PubMed

Klintsova, A. Y., Goodlett, C. R., & Greenough, W. T. (2000). Therapeutic motor training ameliorates cerebellar effects of postnatal binge alcohol. Neurotoxicology and Teratology, 22(1), 125–132.PubMedCrossRef

Klintsova, A. Y., Scamra, C., Hoffman, M., Napper, R. M., Goodlett, C. R., & Greenough, W. T. (2002). Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats: II. A quantitative stereological study of synaptic plasticity in female rat cerebellum. Brain Research, 937(1–2), 83–93.PubMedCrossRef

Klintsova, A. Y., Dickson, E., Yoshida, R., & Greenough, W. T. (2004). Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise. Brain Research, 1028(1), 92–104.PubMedCrossRef

Kodituwakku, P. W. (2007). Defining the behavioral phenotype in children with fetal alcohol spectrum disorders: a review. Neuroscience and Biobehavioral Reviews, 31, 192–201.PubMedCrossRef

Kodituwakku, P. W. (2009). Neurocognitive profile in children with fetal alcohol spectrum disorders. Developmental Disabilities Research Reviews, 15(3), 218–224.PubMedCrossRef

Kodituwakku, P. W. (2010). A neurodevelopmental framework for the development of interventions for children with fetal alcohol spectrum disorders. Alcohol, 44(7–8), 717–728.PubMedCrossRef

Kodituwakku, P. W., Handmaker, N. S., Cutler, S. K., Weathersby, E. K., & Handmaker, S. D. (1995). Specific impairments in self-regulation in children exposed to alcohol prenatally. Alcoholism, Clinical and Experimental Research, 19(6), 1558–1564.PubMedCrossRef

Kodituwakku, P. W., Kalberg, W., & May, P. A. (2001). The effects of prenatal alcohol exposure on executive functioning. Alcohol Research & Health, 25(3), 192–198.

Kodituwakku, P. W., Segall, J. M., & Beatty, G. K. (2011). Cognitive and behavioral effects of prenatal alcohol expsoure. Future Neurology, 6(2), 237–259.CrossRef

Kohl, P., Crampin, E. J., Quinn, T. A., & Noble, D. (2010). Systems biology: an approach. Clinical and Pharmacological Therapeutics, 88(1), 25–33.CrossRef

Kopera-Frye, K., Dehaene, S., & Streissguth, A. P. (1996). Impairments of number processing induced by prenatal alcohol exposure. Neuropsychologia, 34(12), 1187–1196.PubMedCrossRef

Krahe, T. E., Wang, W., & Medina, A. E. (2009). Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disorders. PLoS ONE, 4(8), e6643.PubMedCrossRef

Lebel, C., Roussotte, F. F., & Sowell, E. R. (2011). Imaging the impact of prenatal alcohol exposure on the structure of the developing human brain. Neuropsychology Review, 21(2), in press.

Lee, M. H., & Rabe, A. (1999). Infantile handling eliminates reversal learning deficit in rats prenatally exposed to alcohol. Alcohol, 18(1), 49–53.PubMedCrossRef

Lee, J. H., Tajuddin, N. F., & Druse, M. J. (2009). Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons. Brain Research, 1249, 54–60.PubMedCrossRef

Lemoine, P., Harousseau, H., Borteyru, J. P., & Menuet, J. C. (1968). Les enfants des parents alcoholiques: anomailes observees a propos de 127 cas. Quest Medical, 25, 476–487.

Levine, S. (1956). A further study of infantile handling and adult avoidance learning. Journal of Personality, 25(1), 70–80.PubMedCrossRef

Lippert-Gruener, M., Maegele, M., Garbe, J., & Angelov, D. N. (2007). Late effects of enriched environment (EE) plus multimodal early onset stimulation (MEOS) after traumatic brain injury in rats: Ongoing improvement of neuromotor function despite sustained volume of the CNS lesion. Experimental Neurology, 203(1), 82–94.PubMedCrossRef

Loomes, C., Rasmussen, C., Pei, J., Manji, S., & Andrew, G. (2008). The effect of rehearsal training on working memory span of children with fetal alcohol spectrum disorder. Research in Developmental Disabilities, 29(2), 113–124.PubMedCrossRef

Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews. Neuroscience, 10(6), 434–445.PubMedCrossRef

Lupton, C., Burd, L., & Harwood, R. (2004). Cost of fetal alcohol spectrum disorders. American Journal of Medical Genetics. Part C: Seminars in Medical Genetics, 127C(1), 42–50.

Marcri, S., Spinelli, S., Adriani, W., Higley, J. D., & Laviola, G. (2007). Early adversity ad alcohol availability persistently modify serotonin ad hypothalamic-pituitary-adrenal-axis metabolism and related behavior: what experimental research on rodents and primates can tell us. Neuroscience and Biobehavioral Reviews, 31(2), 172–180.CrossRef

Mattson, S. N., Gramling, L., Delis, D. C., Jones, K. L., & Riley, E. P. (1996). Global-local processing in children prenatally exposed to alcohol. Child Neuropsychology, 2, 165–175.CrossRef

Mattson, S. N., Riley, E. P., Gramling, L., Delis, D. C., & Jones, K. L. (1997). Heavy prenatal alcohol exposure with or without physical features of fetal alcohol syndrome leads to IQ deficits. Pediatrics, 131(5), 718–721.

Mattson, S. N., Goodman, A. M., Caine, C., Delis, D. C., & Riley, E. P. (1999). Executive functioning in children with heavy prenatal alcohol exposure. Alcoholism, Clinical and Experimental Research, 23(11), 1808–1815.PubMedCrossRef

Mattson, S. N., Roesch, S. C., Fagerlund, A., Autti-Ramo, I., Jones, K. L., May, P. A., et al. (2010). Toward a neurobehavioral profile of fetal alcohol spectrum disorders. Alcoholism, Clinical and Experimental Research, 34(9), 1640–1650.PubMedCrossRef

McGee, C. L., Fryer, S. L., Bjorkquist, O. A., Mattson, S. N., & Riley, E. P. (2008). Deficits in social problem solving in adolescents with prenatal exposure to alcohol. The American Journal of Drug and Alcohol Abuse, 34(4), 423–431.PubMedCrossRef

Meaney, M. J., Viau, V., Aitken, D. H., & Bhatnagar, S. (1988). Stress-induced occupancy and translocation of hippocampal glucocorticoid receptors. Brain Research, 445(1), 198–203.PubMedCrossRef

Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., et al. (1996). Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Developmental Neuroscience, 18(1–2), 49–72.PubMedCrossRef

Medina, A. E., & Krahe, T. E. (2008). Neocortical plasticity deficits in fetal alcohol spectrum disorders: lessons from barrel and visual cortex. Journal of Neuroscience Research, 86(2), 256–263.PubMedCrossRef

Medina, A. E., Krahe, T. E., & Ramoa, A. S. (2006). Restoration of neuronal plasticity by a phosphodiesterase type 1 inhibitor in a model of fetal alcohol exposure. The Journal of Neuroscience, 26(3), 1057–1060.PubMedCrossRef

Meintjes, E. M., Jacobson, J. L., Molteno, C. D., Gatenby, J. C., Warton, C., Cannistraci, C. J., et al. (2010). An FMRI study of number processing in children with fetal alcohol syndrome. Alcoholism, Clinical and Experimental Research, 34(8), 1450–1464.PubMed

Mitchell, J. J., Paiva, M., & Heaton, M. B. (1999). Vitamin E and beta-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome. Neuroscience Letters, 263(2–3), 189–192.PubMedCrossRef

Molina, B. S., Hinshaw, S. P., Swanson, J. M., Arnold, L. E., Vitiello, B., Jensen, P. S., et al. (2009). The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study. Journal of the American Academy of Child and Adolescent Psychiatry, 48(5), 484–500.PubMedCrossRef

Mothes, H. K., Opitz, B., Werner, R., & Clausing, P. (1996). Effects of prenatal ethanol exposure and early experience on home-cage and open-field activity in mice. Neurotoxicology and Teratology, 18(1), 59–65.PubMedCrossRef

Muraven, M., & Baumeister, R. F. (2000). Self-regulation and depletion of limited resources: does self-control resemble a muscle? Psychological Bulletin, 126(2), 247–259.PubMedCrossRef

Nathan, P., & Gorman, J. M. (Eds.). (2002). Guide to treatments that work. New York: Oxford University Press.

Noble, D. (2008). Mind over molecules: activating biological demons. Annals of the New York Academy of Sciences, 1123, XI–XIX.PubMedCrossRef

O’Connor, M. J., & Paley, B. (2006). The relationship of prenatal alcohol exposure and the postnatal environment to child depressive symptoms. Journal of Pediatric Psychology, 31(1), 50–64.PubMed

O’Connor, M. J., Sigman, M., & Brill, N. (1987). Disorganization of attachment in relation to maternal alcohol consumption. Journal of Consulting and Clinical Psychology, 55(6), 831–836.PubMedCrossRef

O’Connor, M. J., Shah, B., Whaley, S., Cronin, P., Gunderson, B., & Graham, J. (2002). Psychiatric illness in a clinical sample of children with prenatal alcohol exposure. The American Journal of Drug and Alcohol Abuse, 28(4), 743–754.PubMedCrossRef

O’Connor, M. J., Frankel, F., Paley, B., Schonfeld, A. M., Carpenter, E., Laugeson, E. A., et al. (2006). A controlled social skills training for children with fetal alcohol spectrum disorders. Journal of Consulting and Clinical Psychology, 74(4), 639–648.PubMedCrossRef

O’Leary-Moore, S., Parnell, S. E., Lipinski, R. J., & Sulik, K. K. (2011). Magnetic-resonance based imaging in animal models of fetal alcohol spectrum disorders. Neuropsychology Review, 21(2), in press.

O’Malley, K. D., & Nanson, J. (2002). Clinical implications of a link between fetal alcohol spectrum disorder and attention-deficit hyperactivity disorder. Canadian Journal of Psychiatry, 47(4), 349–354.

O’Malley, K. D., Koplin, B., & Dohner, V. A. (2000). Psychostimulant clinical response in fetal alcohol syndrome. Canadian Journal of Psychiatry, 45(1), 90–91.

Oesterheld, J. R., Kofoed, L., Tervo, R., Fogas, B., Wilson, A., & Fiechtner, H. (1998). Effectiveness of methylphenidate in Native American children with fetal alcohol syndrome and attention deficit/hyperactivity disorder: a controlled pilot study. Journal of Child and Adolescent Psychopharmacology, 8(1), 39–48.PubMedCrossRef

Paley, B., & O’Connor, M. J. (2009). Intervention for individuals with fetal alcohol spectrum disorders: treatment approaches and case management. Developmental Disabilities Research Reviews, 15(3), 258–267.PubMedCrossRef

Parnell, S. E., Chen, S. Y., Charness, M. E., Hodge, C. W., Dehart, D. B., & Sulik, K. K. (2007). Concurrent dietary administration of D-SAL and ethanol diminishes ethanol’s teratogenesis. Alcoholism, Clinical and Experimental Research, 31(12), 2059–2064.PubMedCrossRef

Parnell, S. E., Sulik, K. K., Dehart, D. B., & Chen, S. Y. (2010). Reduction of ethanol-induced ocular abnormalities in mice through dietary administration of N-acetylcysteine. Alcohol, 44(7–8), 699–705.PubMedCrossRef

Patterson, G. R., McNeal, N., Hawkins, N., & Phelps, R. (1967). Reprogramming the social environment. Journal of Child Psychology and Psychiatry, 8, 181–195.CrossRef

Peadon, E., Rhys-Jones, B., Bower, C., & Elliott, E. J. (2009). Systematic review of interventions for children with Fetal Alcohol Spectrum Disorders. BMC Pediatrics, 9, 35.PubMedCrossRef

Premji, S., Benzies, K., Serrett, K., & Hayden, K. A. (2007). Research-based interventions for children and youth with a Fetal Alcohol Spectrum Disorder: revealing the gap. Child: Care, Health and Development, 33(4), 389–397. discussion 398–400.CrossRef

Rasmussen, C., & Bisanz, J. (2008). Executive functioning in children with fetal alcohol spectrum disorders: profiles and age-related differences. Child Neuropsychology, 1–15.

Renner, M. J., & Rosenzweig, M. R. (1987). Enriched and impoverished environments: Effects on brain and behavior. New York: Springer.

Riley, E. P., Mattson, S. N., Li, T. K., Jacobson, S. W., Coles, C. D., Kodituwakku, P. W., et al. (2003). Neurobehavioral consequences of prenatal alcohol exposure: an international perspective. Alcoholism, Clinical and Experimental Research, 27(2), 362–373.PubMedCrossRef

Robertson, I. H. (2002). Cognitive neuroscience and brain rehabilitation: a promise kept. Journal of Neurology, Neurosurgery and Psychiatry, 73(4), 357.CrossRef

Rueda, M. R., Rothbart, M. K., McCandliss, B. D., Saccomanno, L., & Posner, M. I. (2005). Training, maturation, and genetic influences on the development of executive attention. The Proceedings of the Natlonal Academy of Science of the United States of America, 102(41), 14931–14936.CrossRef

Ryan, S. H., Williams, J. K., & Thomas, J. D. (2008). Choline supplementation attenuates learning deficits associated with neonatal alcohol exposure in the rat: effects of varying the timing of choline administration. Brain Research, 1237, 91–100.PubMedCrossRef

Santostefano, S. (1978). A bio-developmental approach to clinical child psychology: cognitive control therapy. New York: Wiley.

Santostefano, S. (1985). Cognitive control therapy for children and adolescents. New York: Pergamon.

Sari, Y., Powrozek, T., & Zhou, F. C. (2001). Alcohol deters the outgrowth of serotonergic neurons at midgestation. Journal of Biomedical Science, 8(1), 119–125.PubMedCrossRef

Savage, D. D., Rosenberg, M. J., Wolff, C. R., Akers, K. G., El-Emawy, A., Staples, M. C., et al. (2010). Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits. Alcoholism, Clinical and Experimental Research, 34(10), 1793–1802.PubMedCrossRef

Seligman, M. E. (1995). The effectiveness of psychotherapy. The Consumer Reports Study. The American Psychologist, 50(12), 965–974.PubMedCrossRef

Shonkoff, J. P., & Phillips, D. A. (Eds.). (2000). From neurons to neighborhoods. Washington: National Academy Press.

Sirois, S., Spratling, M., Thomas, M. S., Westermann, G., Mareschal, D., & Johnson, M. H. (2008). Precis of neuroconstructivism: how the brain constructs cognition. The Behavioral and Brain Sciences, 31(3), 321–331. discussion 331–356.PubMed

Snyder, J., Nanson, J., Snyder, R. E., & Block, G. W. (1997). Stimulant efficacy in children with FAS. In A. Streissguth & J. Kanter (Eds.), The challenge of fetal alcohol syndrome: overcoming secondary disabilities (pp. 64–77). Seattle: University of Washington Press.

Spong, C. Y., Abebe, D. T., Gozes, I., Brenneman, D. E., & Hill, J. M. (2001). Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. The Journal of Pharmacology and Experimental Therapeutics, 297(2), 774–779.PubMed

Stratton, K., Howe, C., & Battaglia, F. (Eds.). (1996). Fetal alcohol syndrome: Diagnosis, epidemiology, prevention, and teatment. Washington: National Academy Press.

Streissguth, A. P., Barr, H. M., Olson, H. C., Sampson, P. D., Bookstein, F. L., & Burgess, D. M. (1994). Drinking during pregnancy decreases word attack and arithmetic scores on standardized tests: adolescent data from a population-based prospective study. Alcoholism, Clinical and Experimental Research, 18(2), 248–254.PubMedCrossRef

Streissguth, A. P., Bookstein, F. L., Barr, H. M., Press, S., & Sampson, P. D. (1998). A fetal alcohol behavior scale. Alcoholism, Clinical and Experimental Research, 22(2), 325–333.PubMedCrossRef

Streissguth, A. P., Bookstein, F. L., Barr, H. M., Sampson, P. D., O’Malley, K., & Young, J. K. (2004). Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects. Journal of Developmental and Behavioral Pediatrics, 25(4), 228–238.PubMedCrossRef

Tajuddin, N. F., & Druse, M. J. (1999). In utero ethanol exposure decreased the density of serotonin neurons. Maternal ipsapirone treatment exerted a protective effect. Brain Research. Developmental Brain Research, 117(1), 91–97.PubMedCrossRef

The MTA Cooperative Group. (1999). A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Archives of General Psychiatry, 56(12), 1073–1086.CrossRef

Thelen, E., & Esther, L. B. (1994). A dynamic systems approach to the development of cognition and action. Cambridge: MIT.

Thomas, S. E., Kelly, S. J., Mattson, S. N., & Riley, E. P. (1998). Comparison of social abilities of children with fetal alcohol syndrome to those of children with similar IQ scores and normal controls. Alcoholism, Clinical and Experimental Research, 22(2), 528–533.PubMedCrossRef

Thomas, J. D., La Fiette, M. H., Quinn, V. R., & Riley, E. P. (2000). Neonatal choline supplementation ameliorates the effects of prenatal alcohol exposure on a discrimination learning task in rats. Neurotoxicology and Teratology, 22(5), 703–711.PubMedCrossRef

Thomas, J. D., Garrison, M., & O’Neill, T. M. (2004). Perinatal choline supplementation attenuates behavioral alterations associated with neonatal alcohol exposure in rats. Neurotoxicology and Teratology, 26(1), 35–45.PubMedCrossRef

Thomas, J. D., O’Neill, T. M., & Dominguez, H. D. (2004). Perinatal choline supplementation does not mitigate motor coordination deficits associated with neonatal alcohol exposure in rats. Neurotoxicology and Teratology, 26(2), 223–229.PubMedCrossRef

Thomas, J. D., Biane, J. S., O’Bryan, K. A., O’Neill, T. M., & Dominguez, H. D. (2007). Choline supplementation following third-trimester-equivalent alcohol exposure attenuates behavioral alterations in rats. Behavioral Neuroscience, 121(1), 120–130.PubMedCrossRef

Thomas, J. D., Abou, E. J., & Dominguez, H. D. (2009). Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats. Neurotoxicology and Teratology, 31(5), 303–311.PubMedCrossRef

Thomas, J. D., Idrus, N. M., Monk, B. R., & Dominguez, H. D. (2010). Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. Birth Defects Research. Part A, Clinical and Molecular Teratololgy, 88(10), 827–837.CrossRef

Tran, T. D., Jackson, H. D., Horn, K. H., & Goodlett, C. R. (2005). Vitamin E does not protect against neonatal ethanol-induced cerebellar damage or deficits in eyeblink classical conditioning in rats. Alcoholism, Clinical and Experimental Research, 29(1), 117–129.PubMedCrossRef

Uecker, A., & Nadel, L. (1996). Spatial locations gone awry: object and spatial memory deficits in children with fetal alcohol syndrome. Neuropsychologia, 34(3), 209–223.PubMedCrossRef

Vaglenova, J., & Vesselinov Petkov, V. (2001). Can nootropic drugs be effective against the impact of ethanol teratogenicity on cognitive performance? European Journal of Neuropsychopharmacology, 11(1), 33–40.CrossRef

Vaglenova, J., Pandiella, N., Wijayawardhane, N., Vaithianathan, T., Birru, S., Breese, C., et al. (2008). Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. Neuropsychopharmacology, 33(5), 1071–1083.PubMedCrossRef

Varaschin, R. K., Akers, K. G., Rosenberg, M. J., Hamilton, D. A., & Savage, D. D. (2010). Effects of the cognition-enhancing agent ABT-239 on fetal ethanol-induced deficits in dentate gyrus synaptic plasticity. The Journal of Pharmacology and Experimental Therapeutics, 334(1), 191–198.PubMedCrossRef

Vink, J., Auth, J., Abebe, D. T., Brenneman, D. E., & Spong, C. Y. (2005). Novel peptides prevent alcohol-induced spatial learning deficits and proinflammatory cytokine release in a mouse model of fetal alcohol syndrome. American Journal of Obstetrics and Gynecology, 193(3 Pt 1), 825–829.PubMedCrossRef

Vygotsky, L. S. (1962). Thought and language. Cambridge: MIT.CrossRef

Wagner, A. F., & Hunt, P. S. (2006). Impaired trace fear conditioning following neonatal ethanol: reversal by choline. Behavioral Neuroscience, 120(2), 482–487.PubMedCrossRef

Wainwright, P. E., Levesque, S., Krempulec, L., Bulman-Fleming, B., & McCutcheon, D. (1993). Effects of environmental enrichment on cortical depth and Morris-maze performance in B6D2F2 mice exposed prenatally to ethanol. Neurotoxicology and Teratology, 15(1), 11–20.PubMedCrossRef

Weinberg, J., Kim, C. K., & Yu, W. (1995). Early handling can attenuate adverse effects of fetal ethanol exposure. Alcohol, 12(4), 317–327.PubMedCrossRef

Westermann, G., Mareschal, D., Johnson, M. H., Sirois, S., Spratling, M. W., & Thomas, M. S. (2007). Neuroconstructivism. Developmental Science, 10(1), 75–83.PubMedCrossRef

Whaley, S. E., O’Connor, M., & Gunderson, B. (2001). Comparison of the adaptive functioning of children prenatally exposed to alcohol to a nonexposed clinical sample. Alcoholism, Clinical and Experimental Research, 25(7), 1018–1024.PubMedCrossRef

Whitaker-Azmitia, P. M., Druse, M., Walker, P., & Lauder, J. M. (1996). Serotonin as a developmental signal. Behavioral Brain Research, 73(1–2), 19–29.

Wijayawardhane, N., Shonesy, B. C., Vaithianathan, T., Pandiella, N., Vaglenova, J., Breese, C. R., et al. (2008). Ameliorating effects of preadolescent aniracetam treatment on prenatal ethanol-induced impairment in AMPA receptor activity. Neurobiology of Disease, 29(1), 81–91.PubMedCrossRef

Wilkemeyer, M. F., Chen, S. Y., Menkari, C. E., Sulik, K. K., & Charness, M. E. (2004). Ethanol antagonist peptides: structural specificity without stereospecificity. The Journal of Pharmacology and Experimental Therapeutics, 309(3), 1183–1189.PubMedCrossRef

Williams, M. S., & Shellenberger, S. (1996). How does the engine run? A leader’s guide to the alert program. Albuquerque: Therapyworks Inc.

Wozniak, J., & Muetzel, R. (2011). What does duffuse tensor imaging reveal about the brain and cognition in fetal alcohol spectrum disorders? Neuropsychology Review, 21(2), in press.

Zeisel, S. H. (2006). Choline: critical role during fetal development and dietary requirements in adults. Annual Review of Nutrition, 26, 229–250.PubMedCrossRef

Zhou, F. C., Sari, Y., Zhang, J. K., Goodlett, C. R., & Li, T. (2001). Prenatal alcohol exposure retards the migration and development of serotonin neurons in fetal C57BL mice. Brain Research. Developmental Brain Research, 126(2), 147–155.PubMedCrossRef

Zhou, F. C., Sari, Y., Powrozek, T. A., & Spong, C. Y. (2004). A neuroprotective peptide antagonizes fetal alcohol exposure-compromised brain growth. Journal of Molecular Neuroscience, 24(2), 189–199.PubMedCrossRef

Zhou, F. C., Sari, Y., & Powrozek, T. A. (2005). Fetal alcohol exposure reduces serotonin innervation and compromises development of the forebrain along the serotonergic pathway. Alcoholism, Clinical and Experimental Research, 29(1), 141–149.PubMedCrossRef

Zhou, F. C., Fang, Y., & Goodlett, C. (2008). Peptidergic agonists of activity-dependent neurotrophic factor protect against prenatal alcohol-induced neural tube defects and serotonin neuron loss. Alcoholism, Clinical and Experimental Research, 32(8), 1361–1371.PubMedCrossRef

Titel: From Research to Practice: An Integrative Framework for the Development of Interventions for Children with Fetal Alcohol Spectrum Disorders
verfasst von: Piyadasa W. Kodituwakku
E. Louise Kodituwakku
Publikationsdatum: 01.06.2011
Verlag: Springer US
Erschienen in: Neuropsychology Review / Ausgabe 2/2011
Print ISSN: 1040-7308
Elektronische ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-011-9170-1

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2011

The Effects of Prenatal Alcohol Exposure on Behavior: Rodent and Primate Studies

Fetal Alcohol Spectrum Disorders: An Overview

Functional Neuroimaging in the Examination of Effects of Prenatal Alcohol Exposure

Imaging the Impact of Prenatal Alcohol Exposure on the Structure of the Developing Human Brain

Magnetic Resonance-Based Imaging in Animal Models of Fetal Alcohol Spectrum Disorder