Erschienen in:
01.11.2006 | Poster Presentation
Functional analysis of normal and DCIS modified breast myoepithelial cells
verfasst von:
M Allen, K Mulligan, S Clark, I Hart, JF Marshall, JL Jones
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2006
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Excerpt
Normal breast myoepithelial cells have been shown to exhibit tumour-suppressor activity mediated, in part, by downregulation of MMP expression [
1]. DCIS myoepithelial cells have an altered phenotype as demonstrated by a different gene expression profile [
2]. We have identified upregulation of α(v)β
6 integrin on myoepithelial cells in a subset of DCIS; however, the role of α(v)β
6 in this context is not clear. α(v)β
6 is not expressed by normal epithelial cells, but is expressed in some cancers where it promotes tumour cell invasion and enhances MMP expression. …