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Erschienen in: Breast Cancer Research 2/2006

01.11.2006 | Poster Presentation

Functional analysis of normal and DCIS modified breast myoepithelial cells

verfasst von: M Allen, K Mulligan, S Clark, I Hart, JF Marshall, JL Jones

Erschienen in: Breast Cancer Research | Sonderheft 2/2006

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Excerpt

Normal breast myoepithelial cells have been shown to exhibit tumour-suppressor activity mediated, in part, by downregulation of MMP expression [1]. DCIS myoepithelial cells have an altered phenotype as demonstrated by a different gene expression profile [2]. We have identified upregulation of α(v)β6 integrin on myoepithelial cells in a subset of DCIS; however, the role of α(v)β6 in this context is not clear. α(v)β6 is not expressed by normal epithelial cells, but is expressed in some cancers where it promotes tumour cell invasion and enhances MMP expression. …
Literatur
1.
Zurück zum Zitat Jones J, Shaw J, Pringle J, Wlaker R: Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells. J Pathol. 2003, 201: 562-572. 10.1002/path.1483.CrossRefPubMed Jones J, Shaw J, Pringle J, Wlaker R: Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells. J Pathol. 2003, 201: 562-572. 10.1002/path.1483.CrossRefPubMed
2.
Zurück zum Zitat Allinen M, Beroukhim R, Cai L, et al: Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell. 2004, 6: 17-32. 10.1016/j.ccr.2004.06.010.CrossRefPubMed Allinen M, Beroukhim R, Cai L, et al: Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell. 2004, 6: 17-32. 10.1016/j.ccr.2004.06.010.CrossRefPubMed
Metadaten
Titel
Functional analysis of normal and DCIS modified breast myoepithelial cells
verfasst von
M Allen
K Mulligan
S Clark
I Hart
JF Marshall
JL Jones
Publikationsdatum
01.11.2006
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 2/2006
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1569

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