Background
Methods
Study population
MR imaging
Left ventricular size and function
Infarct size and transmurality
Feature tracking analysis
Statistical analysis
Results
Left ventricular volumes and LVEF
Scar | Non-scar | p | |
---|---|---|---|
(n = 17) | (n = 13) | ||
Cine-MRI
| |||
View Forum
| |||
LVEDV, ml | 160 ± 42 (102 - 269) | 137 ± 16 (115 - 170) | 0.049 |
LVESV, ml | 99 ± 35 (51 - 188) | 55 ± 16 (25 - 90) | 0.0001 |
LVEF,% | 39 ± 9 (19 - 53) | 60 ± 8 (47 - 78) | <0.0001 |
Diogenes MRI
| |||
LVEF,% | 50 ± 8 (31-64) | 65 ± 4 (58-70) | <0.0001 |
LGE-MRI
| |||
Segment
| |||
LVEDV, ml | 157 ± 40 (113 - 264) | 128 ± 27 (81 - 166) | 0.027 |
LVmass, g | 190 ± 37 (151 - 266) | 154 ± 25 (110 - 180) | 0.004 |
LVscar,% | 16.6 ± 8.4 (1 - 35) | 0.2 ± 0.4 (0 - 1) | - |
Transmurality | number of segments | number of segments | |
<1% | 141 | 234 | |
1-25% | 36 | 0 | |
26-50% | 22 | 0 | |
51-75% | 29 | 0 | |
76-100% | 78 | 0 |
Segmental scar area
Functional measurements
Scar | Non-scar | |||||||
---|---|---|---|---|---|---|---|---|
LAD (n = 187) | Remote (n = 119) | LAD (n = 187) | Remote (n = 119) | |||||
Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | |
Displacement, mm
| ||||||||
Radial | 3.28* | (2.85-3.72) | 7.09§
| (6.51-7.68) | 7.15* | (6.76-7.53) | 8.19 | (7.65-8.73) |
Longitudinal | 2.87* | (2.51-3.23) | 4.10§
| (3.57-4.64) | 4.05* | (3.48-4.62) | 5.77 | (5.03-6.50) |
Velocity, cm/s
| ||||||||
Radial | 1.56* | (1.31-1.80) | 3.32§
| (3.06-3.57) | 3.37* | (3.17-3.57) | 3.74 | (3.49-3.99) |
Longitudinal | 1.71* | (1.50-1.92) | 2.62§
| (2.30-2.94) | 2.25* | (2.01-2.48) | 3.26 | (2.94-3.57) |
Strain, %
| ||||||||
Radial | 30.50* | (27.60-33.39) | 65.90§
| (60.80-70.99) | 70.80* | (66.24-75.37) | 80.49 | (72.20-88.78) |
Longitudinal | -10.3* | (-11.2 to -9.3) | -15.8§
| (-17.4 to -14.2) | -23.3* | (-24.5 to -22.1) | -19.9 | (-21.9 to -17.9) |
Composite | Radial strain | Radial displacement | Radial velocity | Longitudinal strain | Longitudinal velocity | Longitudinal displacement | |
---|---|---|---|---|---|---|---|
ROC area
| 0.905 | 0.892 | 0.879 | 0.855 | 0.764 | 0.588 | 0.535 |
95% conf. int. | 0.877-0.929 | 0.863-0.917 | 0.848-0.906 | 0.822-0.883 | 0.726-0.799 | 0.545-0.630 | 0.491-0.578 |
Cut off value*
| 2.52 | 38.8 | 3.97 | 1.82 | -18.5 | 2.49 | 4.99 |
Sens/Spec
| 78/93 | 80/86 | 85/78 | 86/75 | 47/95 | 44/75 | 34/80 |
Cut off value*
| >2.4 | >38.9 | >4.47 | >2.1 | <-9.6 | >1.1 | >1.29 |
Sens at Spec = 80%
| 90 | 86 | 80 | 78 | 48 | 31 | 19 |
Radial strain | Radial displacement | Radial velocity | Longitudinal strain | Longitudinal velocity | Longitudinal displacement | |
---|---|---|---|---|---|---|
Composite
| 0.160 (0.457) | 0.001 (0.072) | <0.001 (0.093) | <0.001 (<0.001) | <0.001 (<0.001) | <0.001 (<0.001) |
Radial strain
| - | 0.302 (0.567) | 0.015 (0.417) | <0.001 (<0.001) | <0.001 (<0.001) | <0.001 (<0.001) |
Radial displacement
| - | 0.011 (0.780) | <0.001 (0.004) | <0.001 (<0.001) | <0.001 (<0.001) | |
Radial velocity
| - | 0.001 (0.012) | <0.001 (<0.001) | <0.001 (<0.001) | ||
Longitudinal strain
| - | <0.001 (0.227) | <0.001 (0.021) | |||
Longitudinal velocity
| - | <0.001 (0.114) |
Intra- and interobserver variability
Intraobserver variability (one measurement) | Interobserver variability (mean of 3 measurements) | ||||||
---|---|---|---|---|---|---|---|
ICC | P | Median | Smethod (absolute) | Smethod (% of mean) | Smethod (absolute) | Smethod (% of mean) | |
Displacement, mm
| |||||||
Radial
| 0.93 | <0.001 | 7.1 |
0.75/0.74/0.75 |
11/16/8 |
0.62/0.61/0.64 |
9/13/7 |
Longitudinal
| 0.90 | <0.001 | 3.4 |
1.16/0.83/1.41 |
27/49/20 |
0.78/0.47/0.99 |
18/28/14 |
Velocity, cm/s
| |||||||
Radial
| 0.90 | <0.001 | 3.4 |
0.39/0.33/0.43 |
12/14/10 |
0.29/0.28/0.29 |
9/12/7 |
Longitudinal
| 0.79 | <0.001 | 2.3 |
0.71/0.46/0.90 |
28/33/24 |
0.47/0.27/0.61 |
19/19/17 |
Strain, %
| |||||||
Radial
| 0.74 | <0.001 | 55.4 |
10.9/9.0/12.5 |
21/26/18 |
7.4/6.5/8.2 |
14/18/12 |
Longitudinal
| 0.77 | <0.001 | -17.0 |
4.6/3.5/5.4 |
26/33/22 |
2.7/2.5/2.9 |
15/23/12 |