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Documenta Ophthalmologica

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01.11.2007 | Original Research Article

Functional study in NSE-Hu-Bcl-2 transgenic mice: a model for retinal diseases starting in Müller cells

verfasst von: Cécile Péant, André Dosso, Lorenza Eder-Colli, Florence Chiodini

Erschienen in: Documenta Ophthalmologica | Ausgabe 3/2007

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Abstract

In NSE-Hu-Bcl-2 transgenic mice, line 71, retina undergoes early postnatal degeneration linked to the prior death of Müller cells. The purpose of this study was to complete the characterization of this retinal dysfunction by using electroretinographic (ERG) recordings in both scotopic and photopic conditions. Here, we showed that both rod and cone systems were profoundly affected in NSE-Hu-Bcl-2 transgenic mice as soon as 15 postnatal days in accordance with histological study performed previously.

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Titel: Functional study in NSE-Hu-Bcl-2 transgenic mice: a model for retinal diseases starting in Müller cells
verfasst von: Cécile Péant
André Dosso
Lorenza Eder-Colli
Florence Chiodini
Publikationsdatum: 01.11.2007
Verlag: Springer-Verlag
Erschienen in: Documenta Ophthalmologica / Ausgabe 3/2007
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-007-9077-6

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Functional study in NSE-Hu-Bcl-2 transgenic mice: a model for retinal diseases starting in Müller cells

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