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Tumor Biology
Erschienen in: Tumor Biology 5/2016

27.01.2016 | Review

Gankyrin regulates cell signaling network

verfasst von: Xinxin Wang, Bin Jiang, Yanjie Zhang

Erschienen in: Tumor Biology | Ausgabe 5/2016

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Abstract

Gankyrin is an oncoprotein that facilitates the degradation of two key tumor suppressors, namely, Rb and p53. Although Gankyrin overexpression was identified in different carcinomas eventually and associated with poor prognosis, its function and mechanism remain not well understood. Recently, the signal transduction mechanisms of Gankyrin have been explored, which may provide new drug targets in tumors overexpressing Gankyrin. In this review, we summarize the significant signal transduction pathways regulated by Gankyrin.
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Metadaten
Titel
Gankyrin regulates cell signaling network
verfasst von
Xinxin Wang
Bin Jiang
Yanjie Zhang
Publikationsdatum
27.01.2016
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 5/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-4854-z

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