Gastrointestinal Mantle Cell Lymphoma with Varied Findings

Excerpt

Mantle cell lymphoma (MCL) is a relatively rare B cell lymphoma characterized by overexpression of cyclin D1 associated with t(11;14) (q13;q32) translocation. It is diagnosed by the appearance of lymphocytes histopathologically positive for CD5, CD20, and cyclin D1 and detection of the t(11:14) translocation by genetic analysis. Gastrointestinal tract involvement is found in approximately 20 to 30% of MCL cases [1‐6], and gastrointestinal symptoms and endoscopy may be the starting point for detecting MCL. Most MCLs are often found at advanced Ann Arbor classification stages of III/IV [7] and have a particularly poor prognosis among the B cell lymphomas. Early detection of gastrointestinal MCL is important for the initiation of early therapeutic intervention, but it is not easy to diagnose gastrointestinal MCL endoscopically because the macroscopic findings are diverse. Because it is essential for gastroenterologists to correctly understand the endoscopic image of gastrointestinal MCL, we describe our patient with MCL and review the relevant literature. …