Erschienen in:
Open Access
01.12.2012 | Poster presentation
GCIP, Id like HLH protein, negatively regulates cell proliferation of rheumatoid synovial cells via interaction with CBP
verfasst von:
Hidetoshi Fujita, Minako Nakazawa, Satoko Aratani, Kusuki Nishioka, Akiyoshi Fukamizu, Toshihiro Nakajima
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 1/2012
Einloggen, um Zugang zu erhalten
Excerpt
Rheumatoid arthritis (RA) is one of the most common articular diseases with a prevalence of 1% worldwide [
1,
2]. The clinical features of RA include chronic inflammation of systemic joints associated with synovial hyperplasia followed by impairment of quality of life [
3,
4]. Recently, we have shown that Synoviolin/Hrd1, an E3 ubiquitin ligase, is a novel causative factor for arthropathy [
5]. However, the mechanism that regulates synovial cell outgrowth is not fully understood. …