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Tumor Biology
Erschienen in: Tumor Biology 7/2015

01.07.2015 | Review

Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL

verfasst von: Yang Chen, Zuojun Shen

Erschienen in: Tumor Biology | Ausgabe 7/2015

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Abstract

The antifolate drug methotrexate (MTX) is widely used in the treatment of various neoplastic diseases, including acute lymphoblastic leukemia (ALL). MTX significantly increases cure rates and improves patients’ prognosis. Despite that it achieved remarkable clinical success, a large number of patients still suffer from treatment toxicities or side effects. Even to this date, chemotherapeutic regiments have not been personalized because of interindividual differences that affect MTX response, especially polymorphisms in key genes. The pharmacological pathway of MTX in cells is useful to identify gene polymorphisms that influence the process of treatment. The aim of this review was to discuss the gene polymorphisms of drug-metabolizing enzymes in the MTX pathway and their toxicities on ALL treatment.
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Metadaten
Titel
Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL
verfasst von
Yang Chen
Zuojun Shen
Publikationsdatum
01.07.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 7/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3602-0

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