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Erschienen in:
01.12.2012 | Correspondence
Genes regulating the B cell receptor pathway are recurrently mutated in primary central nervous system lymphoma
Erschienen in: Acta Neuropathologica | Ausgabe 6/2012
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B cell receptor (BCR) signals induce differentiation, proliferation, and apoptosis of B cells. Antigenic stimulation leads to crosslinking of the BCR complex, which consists of immunoglobulin heavy and light chains, one CD79A and one CD79B subunit. As consequence of BCR stimulation, a cascade of signals is induced, activating crucial pathways like the nuclear factor-κB pathway (Fig. 1). Recently, mutations altering CD79B were detected in nodal diffuse large B cell lymphomas (DLBCL) of the activated B cell subtype, which affected BCR signaling [1]. Since primary lymphomas of the central nervous system (PCNSL) also constitute an, albeit distinct, DLBCL entity [5], we investigated whether mutations leading to BCR pathway deregulation may be involved in their pathogenesis.
Fig. 1
Schematic drawing of the B cell receptor pathway. The B cell receptor (BCR) complex consists of the BCR, which recognizes the antigen, and the CD79A and CD79B subunits, both forwarding the receptor signal into the cell. This signaling also activates the NF-κB pathway via the BCM complex consisting of BCL10, CARD11, and MALT protein. The BCR signaling pathway includes several activating (yellow circle) and inhibitory (red circle) proteins. Genes encoding the respective proteins investigated in this study are marked in green
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