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Knee Surgery, Sports Traumatology, Arthroscopy

Erschienen in:

16.04.2016 | Sports Medicine

Genetic biomarkers in non-contact muscle injuries in elite soccer players

verfasst von: Ricard Pruna, Rosa Artells, Matilda Lundblad, Nicola Maffulli

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 10/2017

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Abstract

Purpose

Damage to skeletal muscle necessitates regeneration to maintain proper muscle form and function. Interindividual differences in injury severity, recovery time, and injury rate could be explained by the presence of single nucleotide polymorphisms (SNPs) in genes involved in the reparation and regeneration of connective tissue . We wished to identify new genetic biomarkers that could help to prevent or minimize the risk of non-contact muscle injuries and are associated with a predisposition to developing muscle injuries.

Methods

Using allelic discrimination techniques, we analysed 12 SNPs in selected genes from the genomic DNA of 74 elite soccer players.

Results

SNPs in the hepatocyte growth factor (HGF) gene showed evidence of a statistically significant association with injury incidence, severity, and recovery time. SNPs in the SOX15 gene showed evidence of a statistically significant association with injury incidence. SNPs in the GEFT and LIF genes showed evidence of a statistically significant association with recovery time.

Conclusions

Genetic profile could explain why some elite soccer players are predisposed to suffer more injuries than others and why they need more time to recover from a particular injury. SNPs in HGF genes have an important role as biomarkers of biological processes fragility within muscle injuries related to injury rate, severity, and long recovery time.

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Titel: Genetic biomarkers in non-contact muscle injuries in elite soccer players
verfasst von: Ricard Pruna
Rosa Artells
Matilda Lundblad
Nicola Maffulli
Publikationsdatum: 16.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 10/2017
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-016-4081-6

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