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16.07.2016 | Original Article

Genetic characteristics of highly pathogenic H5N8 avian influenza viruses isolated from migratory wild birds in South Korea during 2014-2015

verfasst von: Young-Jae Si, Won Suk Choi, Young-Il Kim, In-Won Lee, Hyeok-Il Kwon, Su-Jin Park, Eun-Ha Kim, Se mi Kim, Jin-Jung Kwon, Min-Suk Song, Chul-Joong Kim, Young-Ki Choi

Erschienen in: Archives of Virology | Ausgabe 10/2016

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Abstract

The continuous worldwide spread of highly pathogenic avian influenza (HPAI) H5N8 viruses among wild birds and poultry is a potential threat to public health. In the present study, we investigated the genetic characteristics of recent H5N8 viruses continuously isolated from migratory birds over two winters (2013-2014 and 2014-2015) in South Korea. Genetic and phylogenetic analysis demonstrated that the 2014-2015 HPAI H5N8 viruses are closely related to the 2013-2014 viruses, including virulence markers; however, all eight gene segments of 2014-2015 H5N8 viruses clustered in different phylogenetic branches from 2013-2014 H5N8 viruses, except the A/Em/Korea/W492/2015 virus. The H5N8 viruses of Europe and North America belong to sublineages of the 2013-2014 Korean H5N8 viruses but differ from the 2014-2015 Korean H5N8 viruses. Further hemagglutination inhibition (HI) assay results showed that there were 2-to-4 fold differences in HI titer between 2013-2014 and 2014-2015 H5N8 viruses. Taken together, our results suggested that the 2014-2015 Korean H5N8 viruses were genetically and serologically different from those of 2013-2014 winter season H5N8 viruses, including those from Europe and North America.

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Titel: Genetic characteristics of highly pathogenic H5N8 avian influenza viruses isolated from migratory wild birds in South Korea during 2014-2015
verfasst von: Young-Jae Si
Won Suk Choi
Young-Il Kim
In-Won Lee
Hyeok-Il Kwon
Su-Jin Park
Eun-Ha Kim
Se mi Kim
Jin-Jung Kwon
Min-Suk Song
Chul-Joong Kim
Young-Ki Choi
Publikationsdatum: 16.07.2016
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 10/2016
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-016-2979-4

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Genetic characteristics of highly pathogenic H5N8 avian influenza viruses isolated from migratory wild birds in South Korea during 2014-2015

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