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Clinical Reviews in Allergy & Immunology
Erschienen in: Clinical Reviews in Allergy & Immunology 2/2011

01.10.2011

Genetics and Immunopathogenesis of IgA Nephropathy

verfasst von: Hsin-Hui Yu, Kuan-Hua Chu, Yao-Hsu Yang, Jyh-Hong Lee, Li-Chieh Wang, Yu-Tsan Lin, Bor-Luen Chiang

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2/2011

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Abstract

IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. The hallmark of IgAN is underglycosylation in the hinge region of IgA1. Increasing evidence supports the underglycosylated IgA-containing immune-complex including IgG antibodies against the glycans of the hinge region of IgA1 are key factors for mesangial deposition and then trigger inflammation and glomerular injury. The polymeric IgA is produced after aberrant mucosal IgA response. The displacement of mucosal B cells to systemic lymphoid organs and bone marrow may arise from abnormal trafficking of lymphocytes along the mucosa–bone marrow axis involving changes of chemokines and adhesion molecules. This review will summarize the works on the genetics, the mucosal and systemic IgA immune response, mechanism of underglycosylation of IgA1, and the pathological effect of mesangial IgA deposition in IgAN.
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Metadaten
Titel
Genetics and Immunopathogenesis of IgA Nephropathy
verfasst von
Hsin-Hui Yu
Kuan-Hua Chu
Yao-Hsu Yang
Jyh-Hong Lee
Li-Chieh Wang
Yu-Tsan Lin
Bor-Luen Chiang
Publikationsdatum
01.10.2011
Verlag
Humana Press Inc
Erschienen in
Clinical Reviews in Allergy & Immunology / Ausgabe 2/2011
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-010-8232-0

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