Introduction
Results
ChIP-Seq Analysis of EBV and human genomes
Sample | Solexa Illumina Pass Filtered sequence | Mapped to Human Genome | Mapped to EBV Genome | Unmapped |
---|---|---|---|---|
EBNA1 | 14268722 | 10783205(75.57%) | 123764(0.87%) | 3361753(23.56%) |
IgG | 11961444 | 8317994(69.54%) | 35991(0.30%) | 3607459(30.16%) |
Identification of cellular EBNA1 binding sites in chromosome 11 and MAP3K7IP2 promoter region
Validation of EBNA1 ChIP binding sites
Regulation of cellular gene expression by EBNA1
Histone modifications at EBNA1 binding sites
EBNA1 binding site close to the cMyc-IgG translocation break point in Raji Burkitt Lymphoma
Discussion
EBNA1 can interact with a large number of cellular binding sites
Identification of high affinity cellular binding sites
Novel EBNA1 binding sites
EBNA1 regulated cellular genes
Chr | Start | End | Motif | RefSeq gene hit | Dist. to hit | |
---|---|---|---|---|---|---|
chr1 | 52074635 | 52074636 | Motif 5 | NR_031580 | MIR761 | 500 |
chr1 | 91738595 | 91738596 | Motif 3 | NM_001134419 | CDC7 | 500 |
chr1 | 91739305 | 91739306 | Motif 5 | NM_001134420 | CDC7 | 500 |
chr1 | 154170655 | 154170656 | NM_014949 | KIAA0907 | 500 | |
chr10 | 61338790 | 61338791 | Motif 2 | NM_005436 | CCDC6 | 3000 |
chr11 | 6421695 | 6421696 | NM_000613 | HPX | 4000 | |
chr12 | 67007430 | 67007431 | NM_017440 | MDM1 | 5000 | |
chr12 | 108693660 | 108693661 | Motif 2 | NR_026661 | MGC14436 | 4000 |
chr13 | 35769560 | 35769561 | Motif 2 | NM_001144985 | C13orf38 | 500 |
chr13 | 35769000 | 35769001 | NM_001144985 | C13orf38 | 2000 | |
chr14 | 50358425 | 50358426 | Motif 5 | NM_016350 | NIN | 3000 |
chr14 | 23969975 | 23969976 | Motif 4.Motif 5 | NM_015299 | KHNYN | 2000 |
chr14 | 104287630 | 104287631 | Motif 5 | NM_021709 | SIVA1 | 4000 |
chr15 | 26999285 | 26999286 | NM_001130414 | APBA2 | 3000 | |
chr16 | 3222305 | 3222306 | NM_001145447 | ZNF200 | 4000 | |
chr16 | 3221595 | 3221596 | NM_001145447 | ZNF200 | 4000 | |
chr17 | 71770850 | 71770851 | Motif 2 | NM_182565 | FAM100B | 4000 |
chr17 | 1335740 | 1335741 | Motif 4 | NM_001080950 | MYO1C | 500 |
chr17 | 58917775 | 58917776 | Motif 2.Motif 5 | NM_152830 | ACE | 3000 |
chr17 | 64015725 | 64015726 | NM_212471 | PRKAR1A | 4000 | |
chr2 | 190751405 | 190751406 | Motif 5 | NM_001042519 | C2orf88 | 4000 |
chr20 | 49008975 | 49008976 | Motif 2 | NM_014484 | MOCS3 | 500 |
chr20 | 36872330 | 36872331 | Motif 2.Motif 5 | NM_015568 | PPP1R16B | 5000 |
chr22 | 26645510 | 26645511 | NR_026962 | LOC284900 | 500 | |
chr3 | 75761660 | 75761661 | NR_031714 | MIR1324 | 2000 | |
chr6 | 18376590 | 18376591 | NM_001134709 | DEK | 4000 | |
chr6 | 149683865 | 149683866 | Motif 5 | NM_015093 | MAP3K7IP2 | 4000 |
chr6 | 39190140 | 39190141 | NM_018322 | C6orf64 | 2000 | |
chrX | 41428495 | 41428496 | Motif 2 | NM_001097579 | GPR34 | 5000 |