Background
Methods
Marginal linear mixed model
SSU test
Multivariate linear mixed model
USAT and pUSAT
Phenotypic and genotypic data
Results
Simulation study
Type I error | Correlation ρ | |||
---|---|---|---|---|
0 | 0.25 | 0.5 | 0.75 | |
pUSAT | 0.027 | 0.032 | 0.036 | 0.038 |
Real data analysis
Men(N = 407) | Women(N = 414) | Total(N = 821) | ||
---|---|---|---|---|
Log of TGa | 4.86 (0.59) | 4.70 (0.56) | 4.78 (0.58) | |
Log of HDL-Ca | 3.69 (0.23) | 3.92 (0.26) | 3.80 (0.27) | |
Agea | 48.29 (15.93) | 48.38 (15.84) | 48.34 (15.87) | |
Field centerb | Minnesota | 206 (50.6%) | 205 (49.5%) | 411 (50%) |
Utah | 201 (49.4%) | 209 (50.5%) | 410 (50%) | |
Smoking statusb | Never Smoker | 268 (65.8%) | 298 (72.0%) | 566 (68.9%) |
Past Smoker | 106 (26.0%) | 82 (19.8%) | 188 (22.9%) | |
Current Smoker | 33 (8.1%) | 34 (8.2%) | 67 (8.2%) |
SNP | Chr:Pos | Univariate analysis (LMM) | Joint analysis | ||||
---|---|---|---|---|---|---|---|
TG | HDL-C | SSU | mvLMM | USAT | pUSAT | ||
rs90513 | 1:3189344 | 3.33E-02 |
1.20E-06
| 1.30E-05 | 7.18E-06 | 2.36E-05 | 9.88E-06 |
rs11940232 | 4:138953336 | 6.32E-05 | 1.98E-05 |
1.47E-06
| 8.56E-06 |
2.65E-06
|
2.58E-06
|
rs17058802 | 4:173880215 |
5.66E-07
| 4.56E-03 |
2.23E-06
|
3.39E-06
|
4.13E-06
|
2.60E-06
|
rs708010 | 6:37071350 | 1.86E-04 |
4.69E-06
|
1.01E-06
| 5.48E-06 |
2.19E-06
|
2.12E-06
|
rs17619780 | 6:40472303 |
7.58E-08
| 2.22E-01 |
4.95E-06
|
1.59E-07
| 9.60E-06 |
3.01E-07
|
rs12533593 | 7:147451966 | 6.69E-03 |
2.28E-06
| 7.72E-06 | 1.22E-05 | 1.48E-05 | 1.01E-05 |
rs7300117 | 12:130266575 | 2.24E-05 | 8.66E-01 | 5.60E-04 |
3.92E-06
| 9.99E-04 | 8.58E-06 |
rs2880301 | 13:18998534 | 9.66E-01 | 7.29E-02 | 1.95E-01 | 1.19E-01 |
1.69E-13
| 2.22E-01 |
rs17464499 | 22:26221715 | 3.20E-02 |
4.48E-06
| 3.02E-05 | 2.67E-05 | 6.30E-05 | 3.29E-05 |