The review aimed to investigate geographic and sociodemographic factors associated with receipt of systemic anticancer therapies (SACT) for women with secondary (metastatic) breast cancer (SBC).
Methods
Included studies reported geographic and sociodemographic factors associated with receipt of treatment with SACT for women > 18 years with an SBC diagnosis. Information sources searched were Ovid CINAHL, Ovid MEDLINE, Ovid Embase and Ovid PsychINFO. Assessment of methodological quality was undertaken using the Joanna Briggs Institute method. Findings were synthesised using a narrative synthesis approach.
Results
Nineteen studies published between 2009 and 2023 were included in the review. Overall methodological quality was assessed as low to moderate. Outcomes were reported for treatment receipt and time to treatment. Overall treatment receipt ranged from 4% for immunotherapy treatment in one study to 83% for systemic anticancer therapies (unspecified). Time to treatment ranged from median 54 days to 95 days with 81% of patients who received treatment < 60 days.
Younger women, women of White origin, and those women with a higher socioeconomic status had an increased likelihood of timely treatment receipt. Treatment receipt varied by geographical region, and place of care was associated with variation in timely receipt of treatment with women treated at teaching, research and private institutions being more likely to receive treatment in a timely manner.
Conclusions
Treatment receipt varied depending upon type of SACT. A number of factors were associated with treatment receipt. Barriers included older age, non-White race, lower socioeconomic status, significant comorbidities, hospital setting and geographical location. Findings should however be interpreted with caution given the limitations in overall methodological quality of included studies and significant heterogeneity in measures of exposure and outcome. Generalisability was limited due to included study populations.
Findings have practical implications for the development and piloting of targeted interventions to address specific barriers in a socioculturally sensitive manner. Addressing geographical variation and place of care may require intervention at a commissioning policy level. Further qualitative research is required to understand the experience and of women and clinicians.
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Abkürzungen
AJCC
American Joint Committee on Cancer
EoL
End of life
GRADE
Grading of Recommendations, Assessment, Development and Evaluations
HER2
Human epidermal growth factor receptor 2
HR
Hormone receptor status
JBI
Joanna Briggs Institute
MSH
Minority-serving hospital
NCI
National Cancer Institute
NICE
National Institute for Health and Care Excellence
OR
Odds ratio
PRISMA
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
PICO
Population, intervention, comparison and outcomes
RUCA
Rural-urban commuting area
SBC
Secondary (metastatic or advanced) breast cancer
SACT
Systemic anticancer therapies
SERMs
Selective estrogen receptor modulators
SES
Socioeconomic status
Introduction
Over half a million deaths from metastatic or secondary breast cancer (SBC) were estimated worldwide in 2015 with an estimated prevalent population of 57,215 patients with SBC in England in 2021 [1, 2]. Secondary breast cancer is treatable however remains incurable, and despite recent treatment advances, median survival rates have remained stable at 2–3 years over recent years with a 5-year survival rate of 25% [3]. Secondary breast cancer (SBC) has been defined as the development of new tumours in tissues and organs away from the primary tumour site. The most common sites of metastases are lungs, the liver, bones and the brain [4]. Treatment for SBC aims to improve overall survival, increase disease-free progression and improve quality of life whilst balancing toxicities associated with treatment [5]. The majority of patients with SBC receive SACT which may be chemotherapy, targeted therapy, immunotherapy and/or endocrine therapy. Treatment selection is most often guided by tumour biology, and clinical factors and clinical decisions regarding SACT are usually influenced by hormone expression and human epidermal growth factor receptor 2 (HER2) status combined with patient preference, prior therapy (and tolerability), comorbidities and organ function [6]. Receipt of appropriate treatment which is concordant with current, evidence-based clinical guidelines has been associated with improved clinical outcomes for patients with SBC [7, 8]. Treatment disparities related to geographical location have been reported which if left unaddressed may lead to unwarranted variation in outcomes and suggest that geographical access to cancer services remains a concern [9, 10]. The nature and extent of these geographical disparities for women with SBC remain poorly understood.
Addressing geographical disparity is synonymous with promoting equitable access to cancer treatment. At its most, fundamental access to health care has been described as entry into or use of the health care system characterised by those factors which influence entry or use. These include physician numbers and capacity, spatial and geographic relationships between providers of health and the ease with which people can use care, which included clinic hours, waiting time and length of waiting time for an appointment [11]. Contemporary theory of access has proposed a patient-centred framework which suggested that appropriate access to care and treatment occurs at the interface between individual, household and community factors and those of health care systems, institutions, organisations and providers. This was conceptualised in terms of dimensions of accessibility which included approachability, acceptability, availability and accommodation. Corresponding abilities of patients were identified which included a perceived need for health care, ability to seek and reach appropriate health care and the ability to pay combined with the ability to engage. It was proposed that these dimensions of access and abilities of persons interact to generate appropriate, equitable access [12]. The framework has been widely used and was selected as the theoretical framework to guide the review as it provided a contemporary approach to understanding and contextualising access which incorporates principles of patient-centred care of respectful, informed and appropriate care [13, 14]. The framework has been widely cited and was developed through a synthesis of the published literature [15]. The framework provided a useful conceptualisation for classifying individual factors and clinical characteristics and their interface with wider contextual factors to develop a greater understanding of geographic and sociodemographic access to SACT for the treatment of SBC.
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A comprehensive understanding of factors associated with equitable access to SACT for women with SBC is lacking, and to date, there has been no systematic review of the evidence. A systematic review was deemed an appropriate approach to identify gaps in the current evidence and answer the clinical question related to geographic and socioeconomic factors associated with receipt of SACT for the treatment of SBC. The review sought to identify the international evidence to confirm current practice, identify any variation in access to SACT for the treatment of SBC and to identify and inform areas for future research. The review aimed to identify and examine individual, clinical and contextual factors with the intent to measure association between sociodemographic, clinical and geographic factors and receipt of systemic anticancer therapy (SACT) for the treatment of secondary breast cancer (SBC) identifying factors which may act as barriers and enabling factors for receipt of guideline concordant SACT.
Objectives
To review the available evidence to investigate factors associated with receipt of SACT for the treatment of SBC
Identify barriers and enabling factors for treatment access and receipt of SACT.
Explore women and clinicians experience of access and treatment receipt for secondary breast cancer.
Methods
The published review protocol [16] was developed in accordance with the Joanna Briggs Institute guidance (JBI) for developing a mixed-methods systematic review protocol [17]. The protocol was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for systematic review protocols (PRISMA-P) extension statement [18].
No qualitative studies were identified for inclusion. On this basis, it was not possible to address the objective to explore women and clinicians experience of access and treatment receipt for SBC. This necessitated amendment to the published protocol for assessment of methodological quality and risk of bias and data analysis and synthesis. The method reported here is the amended version of the protocol which was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [19].
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Eligibility criteria
Study eligibility was predefined using a modified version of the population, intervention, comparison and outcomes (PICO) framework [20]. Population was women > 18 with an SBC diagnosis. Intervention/exposures were individual factors related to age, gender, sexual orientation, race/ethnicity, socioeconomic status, education, language and literacy and psychosocial characteristics. Clinical characteristics included clinical subtype of disease which included hormone receptor status, HER2 status and previous treatment response. Contextual factors included geographical location, distance, travel time and health care system factors. Comparators were those of standard of care, and the outcome was defined as receipt/nonreceipt of SACT. Studies were ineligible for inclusion where they reported on women with primary/early stage breast cancer only. Males with a secondary breast cancer diagnosis were ineligible as this was classified as a rare disease beyond the scope of the review. Studies which reported comparative treatment effect and efficacy were ineligible as the primary outcome of interest was access, receipt and utilisation of SACT (Additional file 1).
Information sources
Preliminary searches were undertaken in May 2020, updated 20 June 2022 and the final searches reported in the current paper were undertaken on 24 August 2023. Electronic databases searched were Ovid CINAHL, Ovid MEDLINE, Ovid Embase and Ovid PsychINFO accessed through the University of Manchester for original searches and The Christie NHS Foundation Trust library for final searches. NHS Evidence was searched for unpublished studies and grey literature, and the Joanna Briggs Institute Evidence-Based Practice database (JBI EBP) and the Cochrane Library were searched in the original searches. The Cochrane Library was searched in the final searches. Reference lists of included studies were searched. Searches were developed and undertaken with the support of a medical librarian/evidence specialist.
Search strategy
The updated search strategy was developed in accordance with guidance set out in the JBI Manual for Evidence Synthesis. This included the identification of key words in a preliminary (unpublished) nonsystematic review of the literature and analysis of text words contained in the titles and abstracts of papers and of the index terms used in a bibliographic database to describe relevant articles [21]. This informed the development of the search strategy which was conceptually structured using the modified population, intervention, comparison and outcomes (PICO) framework [20]. A validated filter was used for geographic and sociodemographic factors [22]. This filter was applied to updated searches. Searches were limited to English language and studies published from 2000 onwards to include contemporary studies which reflected current trends in access to SACT for SBC. Final updated searches are reported in accordance with the PRISMA-S extension to the PRISMA statement for reporting literature searches in systematic reviews [19, 23] (Additional files 2 and 3). Final updated searches were conducted on 24 August 2023 and were revised and updated to reflect peer reviewer comments.
Study selection
Study titles and abstracts were reviewed against the predefined inclusion and exclusion criteria by the lead author and second reviewer (S. P., J. D. O.). Any disagreements were resolved through discussion. Records were stored and managed in EndNote X9. Potentially eligible studies were retrieved and full text assessed by the two reviewers. Final study selection was approved by the supervisory panel (S. T., A. M., J. Y.). Studies which did not meet inclusion criteria were excluded with reasons for exclusion recorded.
Data collection
Data were extracted and recorded in MS Excel using an adaptation of a standardised data extraction tool which was piloted prior to use. Data extraction was undertaken by the author (S. P.) and second reviewer (J. D. O.). Data for author, year of publication, study design, setting, country, primary data source and study population were extracted. Baseline population demographics for age, race, ethnicity and socioeconomic status were extracted along with primary exposure variables and covariates. Clinical characteristics for diagnosis, clinical subtype and comorbidities were extracted, and contextual factors for place of care, geographical location and population density were extracted, where reported. Numbers for the proportion of women with a secondary breast cancer (SBC) diagnosis included in overall samples was also extracted. This was where the sample was not exclusively women with secondary disease. Data related to the outcome of relevance was extracted as a proportion of studies also reported other nonrelevant outcomes. This included the type of outcome measure, i.e. dichotomous (binary) or continuous, time to event data or a combination of these. Data were extracted from relevant statistical analysis including odds ratios (OR) and hazard ratios (HR) with corresponding confidence intervals (CI) and P-values where these were reported. Three study first authors were contacted to obtain additional data. One reply was received stating that the author no longer had access to additional study data.
Assessment of methodological quality and risk of bias
Methodological quality was assessed using the relevant JBI critical appraisal checklists for cohort and analytical cross-sectional study designs respectively. This included an appraisal of the study population selection method, measures of outcome and relevant exposures, identification and management of potential confounding variables, validity and reliability of outcome measurement and follow-up strategies [24, 25]. The assessment of methodological quality was undertaken independently by the author and second reviewer (S. P., J. D. O.), and any disagreements were resolved through discussion. An overall GRADE quality rating [26] was applied on an individual study level based on the assessment of methodological quality and reporting clarity, specifically the proportion of SBC patients for whom data was reported separately and could be extracted. A weighting was applied to each study based on the overall assessment of methodological quality and the GRADE rating. This was taken into consideration in the analysis and synthesis and reflected in the ‘Discussion’ and ‘Conclusion’. Studies were not excluded based upon low methodological quality.
Synthesis
Synthesis of study findings was undertaken using a narrative synthesis approach [27, 28]. Studies were descriptively summarised in terms of methodological quality, study characteristics and main finding relative to the review objectives. A systematic approach to the synthesis was taken to identify patterns of effects and similarities and differences between studies to provide a comprehensive account of included studies in narrative form. The narrative synthesis was structured around multi-level factors which have previously demonstrated association with access and timely receipt of treatment as the primary outcome measure for the review. This was determined a priori guided by the theoretical model of access adopted to guide the review [12]. Relationships within and between studies were analysed to explore similarities and differences based on different population groups, study settings, exposures, any variability in outcomes and study design. The published protocol specified that where possible, data would be pooled using statistical meta-analysis in accordance with guidance for meta-analysis of observational studies. Due to high levels of heterogeneity in measures of outcome and exposure within and between studies, meta-analysis was precluded.
Results
Study identification and selection
The final updated search undertaken on 24 August 2023 which updated previous searches from December 2020 to June 2022 identified 1693 titles and abstracts. Following removal of 195 duplicates, 1498 title and abstracts were screened against the inclusion and exclusion criteria. One-thousand three-hundred and eighty-five (1385) were excluded. One-hundred and thirteen (113) reports were sought for retrieval for full-text screening. Thirty-three reports were unavailable. Eighty (80) full-text articles were assessed for eligibility. Following full-text screening, 76 were excluded. Studies were excluded where it was not possible to identify secondary breast cancer patients in the analysis, where the primary outcome was not reported for women with SBC, where factors associated with access and receipt of treatment were not reported and where full-text or English language reports were not available. The remaining 4 studies were included in addition to the 15 studies identified from previous searches. A total of 19 studies (n = 19) were included in the review.
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Characteristics of included studies
Nineteen studies published between 2009 and June 2023 were included in the review. A combined overall sample size of 2,032,200 patients were included across all included studies. Included studies varied in the numbers of women with SBC for whom data could be extracted. Eight (n = 8) studies included women with secondary breast cancer exclusively [8, 29‐35]. The remaining eleven studies (n = 11) included subgroups and cohorts of women with a secondary diagnosis [36‐42, 42, 44‐46]. These ranged from 3 to 21% of the overall sample. In total, 276,311 women with secondary breast cancer were included in the analysis and narrative synthesis. Sixteen studies (n = 16) were retrospective cohort design, two cross-sectional study (n = 2) and one descriptive survey design (n = 1). Thirteen studies (n = 13) were conducted in the USA and the remainder across Argentina, Brazil and Turkey. Primary data source for the US studies was either population-based databases or cancer registries (Table 1).
Patients with a confirmed BC diagnosis and without treatment from January to December 2019
Receipt of no SACT treatment
Cancer Hospital Registers (CHR)
-
Age group, race education, marital status, smoking status, alcohol status, region, family history, referral source, tumour, stage at diagnosis
Lack of access to BC treatment
Multivariate regression for factors associated with lack of access to SACT. odds ratio (OR) values with a 95% confidence interval (CI 95%), and estimated p-values
Patients > 40 years with metastatic prostate, lung, colon and breast cancer, diagnosed from January 1, 2004, to December 31, 2015
Chemotherapy
NCDB
Minority serving hospital (top decile) (MSH)
Age, race, year of diagnosis, insurance status, education income, comorbidities
Receipt of specialist palliative care (SPC) which included non-curative systemic chemotherapy
Multilevel logistic regression model which estimated odds of palliative care, adjusted for year of diagnosis, sex, race/ethnicity, insurance, income, educational level and cancer type
Patients > 18 < 64 years at time of death, who died between 1 Jan 2007 and 31 Dec 2014, with metastatic lung, colorectal, breast, pancreatic or prostate cancer with a diagnosis code reflecting metastatic disease during the 12 months preceding death
Chemotherapy
HIRD
Not specified
Age, year of death, population density, geographical region
Receipt of end-of-life (EoL) care which included chemotherapy in the last 14 days of life
Modified Poisson regression models to estimate risk for each outcome, adjusted for age, sex, geographic region, rural/urban location, year of death and regional education and income measures
Women > 18 > 70 diagnosed with breast cancer between 1998 and 2012
Unspecified SACT
NCI HRC
Not specified
Referral route, stage, insurance status, family history, time between diagnosis and treatment, geographic region, marital status, education, race, age
Time between diagnosis and commencement of treatment < 60 days or > 60 days
Logistic regression of time between diagnosis and treatment adjusted for clinical and epidemiologic characteristics. Addition and removal of variables in the model with significance levels for the removal and addition of variables in the models were p ≤ 0.20 and p > 0.05, respectively
Time to receipt of treatment defined as follows: (i) patient delay time (PDT), (ii) system delay time (SDT), and (iii) total delay time = sum of PDT and SDT
Chi-square tests and one-way analysis of variance (ANOVA) for group differences, principal components analysis for variable reduction and multiple regression analysis to build predictive models of PDT, SDT and TDT
Patients ≥ 18 years old with diagnosis of non-small cell lung cancer (NSCLC) or breast cancer, stages I to IV treated with chemotherapy from January 1, 2016
Time elapsed between diagnosis and receipt of treatment with chemotherapy
Kaplan–Meier curves were used to estimate patterns in time to diagnosis and to initial treatment and compared by the log rank test. Cox proportional hazard to explore association between health system and individual and sociodemographic and clinical variables
Patients ≥ 18 years old, diagnosed with HR-positive, HER2-negative MBC between February 3, 2015 (first FDA approval of a CDK4/6i) and July 31, 2021
Cyclin-dependent kinase 4 and 6 (CDK4 and CDK6) inhibitors
Flatiron health database (FHD)
Race
Age at MBC diagnosis, insurance coverage, site of treatment, performance status, year of metastatic diagnosis, the presence or absence of baseline leukopenia
Receipt of cyclin-dependent kinase 4 and 6 (CDK4 and CDK6) inhibitors palbociclib, ribociclib or abemaciclib documented in the FHD at any time after a MBC diagnosis
Multivariable logistic regression models were developed to analyse the association between CDK4/6i use and sociodemographic, clinical characteristics
Patients ≥ 18 years old newly diagnosed with metastatic breast cancer, colorectal cancer and NHL, who received immunotherapy treatment between 1998 and 2004
Immunotherapy
NCDB
Not specified
Age, race, ethnicity, year of diagnosis, insurance status, income, education, facility type
Receipt of immunotherapy following cancer diagnosis
Logistic regressions to examine factors associated with immunotherapy use in each of the three cancers. Separate analysis for the elderly and non-elderly samples to avoid the issue of near collinearity between age and insurance variables
Patients 18 years or older diagnosed with stage IV (defined as metastatic to a distant site, M1 per American Joint Committee on Cancer TNM Staging Criteria), hormone receptor-positive (ER + and/or PR +) and HER2 + breast cancer who received treatment between 2010 and 2015
Not specified
NCDB
Not specified
Age, race/ethnicity, comorbidities, insurance status, income, facility type, distance to treatment, grade, sites of metastases and treatment
Treatment receipt for chemotherapy and hormone (endocrine) therapy
Multivariable logistic regression analyses were conducted to identify independent predictors of treatment receipt (chemotherapy vs. hormonal therapy)
Patients > 18 diagnosed with stage IV cancer of kidney, uterus, NSCLC, SCLC, rectum, colon, prostate, breast and cervix between 2000 and 2008 who did not receive any first‐course therapy
Unspecified SACT
NCDB
Not specified
Age, race, ethnicity, insurance status, education, income
Receipt of no first course anticancer therapy
Log‐binomial regression to estimate prevalence ratios (PRs) with 95% confidence limits (95% CL) relating the percentages of patients receiving no first‐course therapy versus any therapy for stage IV cancer among categories of various socioeconomic and demographic variables. Statistical significance was defined as p < .05
Women > 66 with a first invasive metastatic breast cancer diagnosed between October 1998 and December 2009 enrolled in Parts A/B Medicare
Immunotherapy
SEER-Medicare
Race (White/Black)
Age, marital status, income, education, year of diagnosis, location of residence (metro/nonmetro), geographical location (SEER region), comorbidity, grade, HR status
Time to trastuzumab initiation and utilisation of trastuzumab
Wilcoxon signed-rank tests and multivariable linear regression to examine utilisation adjusting for exposure variables stratified by HR status
Women aged > 65 years diagnosed with HER2-negative MBC during 2010–2013
Unspecified SACT
SEER-Medicare
Not specified
Predisposing characteristics comprised age at diagnosis, race/ethnicity, whilst enabling characteristics included marital status, household income and education
Need-related factors included HR status, grade of tumour, comorbidity scores, performance status and number of sites with cancer metastasis
External care environmental factors comprised the location of residence, SEER region and census level information on the number of hospitals offering oncology services
Receipt of guideline-concordant initial treatment within the first 6 months of a cancer diagnosis
Multivariable logistic regression to identify the significant predictors of guideline-concordant treatment and a non-linear decomposition method to examine disparities by
Women > 65 diagnosed with hormone receptor-positive breast cancer aged between 2006 and 2009 with Part-D claims up to December 2010
Hormone therapy
SEER-Medicare
Not specified
Age, race, marital status, comorbidity, SES, geographical location (SEER region), location of residence (urban/rural), year of diagnosis, stage, grade, lymph node involvement
Receipt of hormone therapy and overall use of hormone therapy 1 year post initiation (stratified by chemotherapy use)
Multivariate logistic regression assessed variation associated with the use of hormone therapy, SERM and AIs, respectively, adjusted for age, gender, race, marriage status, SEER registry area, year of diagnosis, tumour stage, tumour size, radiation therapy status, surgery status and comorbidity
Patients aged > 22 < 65 with newly diagnosed adult-onset breast, cervical colorectal, gastric, hepatobiliary, lung, oral, and pancreatic cancer between 1998 and 2008
Unspecified SACT
NCI LAC
Not specified
Age, race/ethnicity, SES, distance to nearest NCI CCC
Receipt of care which included including SACT at National Cancer Institute Comprehensive Cancer Centre (NCI CCC)
Logistic regression analysis for multivariate modelling of likelihood of receiving care at an NCICCC. Two-sided tests with p < 0.05 were considered statistically significant
All patients across all studies were aged > 18, and of those studies which included exclusively women with SBC, all were aged > 66. There was considerable variation across included studies in reported factors (exposures) associated with treatment receipt and time to treatment. These included demographic variables, i.e. age, race, socioeconomic status, income and education. Reported clinical characteristics included comorbidities, hormone receptor status and year of diagnosis. Contextual variables included geographical location, population density and place of care. Reported outcomes varied across studies, and whilst all studies reported treatment receipt or nonreceipt as either primary or secondary outcomes, measures of treatment receipt differed across studies. These included treatment receipt as a dichotomous outcome, i.e. received/not received, time to treatment as a continuous outcome and treatment received within the context of end-of-life (EoL) care and receipt of no first-line therapy. Characteristics of included studies are presented in Table 1 and Fig. 1.
Fig. 1
Completed PRISMA 2020 flow diagram for updated systematic reviews
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Assessment of methodological quality
Overall methodological quality was assessed as low to moderate. Levels of agreement between author and second reviewer were rated as moderate to high. Clear inclusion and exclusion criteria were specified (with the exception of two studies) which made it possible to determine study population and any differences within and across groups. There were considerable differences across studies in relation to assessment and measurement of exposures. Identification, assessment and management of confounding variables was assessed to determine how this was addressed in the statistical analysis. This was adequately addressed in the majority of studies; however, confounding variables included in analyses varied across studies which made for challenges in comparison across studies. Studies were assessed to determine validity and reliability of outcome measure, and all studies demonstrated this. Grading of Recommendations, Assessment, Development and Evaluations (GRADE) rating was assessed as low to moderate across studies [26]. Based on the assessment of methodological quality, GRADE rating and proportion of secondary breast cancer patients included in each study were attributed a weighting which was reflected in the analysis and synthesis (Table 2).
Table 2
Assessment of methodological quality including proportion of secondary breast cancer patients included, quality rating, GRADE rating and overall study weighting (n = 19)
aJoanna Briggs Institute assessment of methodological quality [24, 25]
bGRADE quality rating [26]. Low, true effect might be markedly different from the estimated effect. Moderate, true effect is probably close to the estimated effect
cOverall study weighting for contribution to narrative synthesis
1 = High
2 = Moderate
3 = Low
Narrative synthesis
The narrative synthesis reported key themes which were identified inductively from outcomes reported across included studies [47, 48]. Themes reflected review objectives to investigate factors associated with receipt of SACT for the treatment of SBC. The process used to conduct the thematic analysis reflected that proposed by Braun and Clarke [47] integrated with guidance on the conduct of narrative synthesis in systematic reviews presented by Popay et al. [28]. Included studies were reviewed, data extracted, and themes identified inductively based on reported outcomes across included studies. The narrative syntheses were structured around included studies which reported key themes for treatment receipt and utilisation, time to treatment and factors associated with time to treatment and treatment utilisation. This provided a framework for the overarching synthesis (Fig. 2).
Fig. 2
Narrative synthesis themes
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Themes were identified for the following:
Access to treatment as defined by receipt and/or treatment utilisation
Access to treatment defined as time to receipt of treatment/treatment utilisation
Factors associated with access to treatment (treatment receipt/utilisation and/or time to receipt of treatment/utilisation
Access to treatment defined as treatment receipt and utilisation
Fifteen studies reported treatment receipt. Treatment receipt was reported for different types of SACT which included chemotherapy, immunotherapy, targeted therapy which included cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i), unspecified SACT and endocrine therapy. Seven studies reported chemotherapy where overall receipt ranged from 22 to 60% [29, 30, 35, 37, 38, 41, 43]. Receipt of endocrine therapy was reported in one study which evaluated factors associated with treatment receipt among women with hormone receptor-positive disease where overall treatment receipt was reported as 70.8% [45]. Receipt of immunotherapy reported in two studies was 4% [34, 42]. Six studies reported treatment receipt with SACT which was unspecified. Two studies reported receipt of no-treatment women who did not receive a first course of treatment; this ranged from 11.1 to 25.5% with 12.8% of women with a breast cancer diagnosis who did not receive a first course of treatment [36, 44] (Table 3).
Table 3
Included studies which reported access to treatment defined as treatment receipt and utilisation (n = 15)
SACT at a National Cancer Institute Comprehensive Cancer Centre (NCI CCC)
Nonspecified SACT
**22–39 years
9.7%
40–65 years 90.3%
Time to treatment
Four studies reported time to treatment [34, 39‐41]. These included two studies which reported time to treatment with non-specified SACT chemotherapy and immunotherapy [39, 40]. Overall, time to treatment ranged from 54 days (median) IQR 32–124 (unadjusted) for White patients compared with 95 days IQR 39–167 for non-White (unadjusted) < 0.05 [34]. Patient delay time was reported as 4.8 weeks with a total delay time of 13.8 weeks [40]. Eighty-one percent of patients received treatment within 60 days [39], and treatment delay differences between public and private hospitals were reported as 76 days (64–86) < 0.0001 and 60 days (52–65) < 0.0001 respectively [41] (Table 4).
Table 4
Table of studies which reported time to treatment as a narrative theme
Factors associated with treatment receipt and time to treatment
Sociodemographic (individual) factors
Age was the most widely reported demographic across studies. For studies which reported adjusted odds ratio (OR), older age was associated with a reduced likelihood of treatment receipt and an increase in delay to treatment for chemotherapy, immunotherapy, unspecified SACT and hormone therapy [34, 39‐41]. For palliative chemotherapy, older women (> 81 years) had a lower likelihood of receipt than those aged < 50 years (reference group) (OR 0.79 0.77–0.82) [37]. Receipt of treatment with immunotherapy was less likely for those in the oldest age quartile compared with those in the youngest (reference group) (Q1 OR 0.28 0.19–0.42) [42]. Older women had a lower likelihood of receipt of CDK4/6i; in particular, women aged > 75 were almost half as likely as younger women for overall use and 20% lower likelihood of first-line use (OR 0.54 0.45–0.64 and OR 0.84 0.72–0.98) respectively [31].
For hormone therapy, likelihood of receipt reduced with increasing age (OR 0.49 0.33–0.71 for those aged 85–89 compared with OR 0.78 0.63–0.97 for those aged 75–79) [45]. Older age was associated with reduced likelihood of treatment receipt at an NCI CCC with older women less likely than younger women to receive treatment (OR 0.7 (0.6–0.8), P < 0.001) [46]. These findings suggested that older women were less likely to receive treatment than younger women. Older age was associated with increased likelihood of receipt of no first-course treatment (36.44), and older women were less likely than younger women to receive SACT as part of end-of-life (EoL) care [29].
Lower likelihood of treatment receipt associated with race was reported with non-White patients less likely to receive treatment and in a less timely manner compared to White counterparts [37, 42, 45, 46]. Asian patients were least likely to receive treatment with palliative chemotherapy compared with White, Black and Hispanic women (OR 0.93 (0.88–0.98)) [37]. These findings were consistent for receipt of hormone therapy, specifically for receipt of SERMs where non-White patients had a lower likelihood of receipt (OR 0.62 (0.43–0.89)) and Black and Hispanic women less likely than White women to receive treatment at NCI CCC (OR 0.5 and 0.7) respectively [45, 46]. Conversely, non-White women were more likely to receive treatment as part of EoL care than white women and were more likely to receive no first-course therapy [29, 37].
For time to treatment and duration of treatment race and ethnicity demonstrated statistically significant difference between 344 days with 61% completion of treatment course for White women compared with 191 days and 44% completion for non-White women, P < 0.005 [34]. Socioeconomic status (SES) was reported across four studies where lower SES was associated with reduced likelihood of treatment receipt [42, 45, 46]. For hormone therapy, those with lower SES were less likely to receive treatment (OR 0.80 0.64–0.98). However, this was for receipt of AIs only [45]. Women with a lower SES were less likely to receive treatment at NCI CCC than women with higher SES (OR 0.3 (0.3–0.4), P < 0.001) [46].
Clinical characteristics
Eighteen studies reported clinical characteristics. These included year of diagnosis, comorbidities, hormone receptor status, stage and grade. Year of diagnosis ranged from 1992 to 2015 and was reported across seven studies. In two studies, those diagnosed in later years were more likely to receive palliative chemotherapy and immunotherapies respectively [37, 42]. Twelve studies reported comorbidities. Two studies reported a statistically significant association between fewer comorbidities and increased likelihood of treatment receipt for chemotherapy and hormone therapy respectively [23, 32]. For chemotherapy, this was reported as a statistically significant difference in proportion of chemotherapy use between 32% for those with no comorbidities to 8% > 2 P < 0.0001. For hormone therapy (without prior chemotherapy), likelihood of treatment receipt decreased with increased comorbidities with OR 0.83 (0.75–0.92) and 0.74 (0.66–0.83) respectively where 0 was the reference category. The inverse was reported for aggressive EOL care with increased likelihood of treatment receipt for those with greater comorbidities (OR 1.20 (1.03–1.39) > 2, OR 2.00 (1.70–2.35)) where those with no comorbidities were the reference group [29]. Similarly, for receipt of palliative care which included non-curative systemic therapy for women with de novo metastatic disease, those with greater comorbidities had an increased likelihood of receipt of palliative care than women with no comorbidities (OR 1.27, 1.17–1.39) [30].
Hormone receptor status was reported across five moderate quality studies which reported data exclusively for patients with a secondary breast cancer diagnosis [8, 29, 30, 34, 35]. Two studies reported chemotherapy receipt and receipt of SACT respectively. Higher proportion of chemotherapy use was found in women with hormone receptor-negative disease, P < 0.001 [35]. The second reported a decreased likelihood of receipt of SACT for women with hormone receptor-negative disease (OR 0.25 (0.17–0.36)) [8].
Five studies reported tumour stage using the American Joint Committee on Cancer (AJCC) classification stages I–IV [35], three of which reported descriptive statistics only. One study reported almost 30% lower likelihood of treatment delay for stage IV diagnosis compared with stage I (OR 0.70 (0.65–0.75) < 0.001) however only included 7% SBC patients as a proportion of the overall sample [26]. The remaining study reported an almost threefold increase (OR 2.67 (1.52–4.67)) in treatment receipt with hormone therapy for those diagnosed with stage IV disease, however included only 4% SBC patients as part of the overall sample [45].
Contextual factors
Sixteen studies reported contextual factors which included geographical location of residence, population density and place of care. Health care system factors related to area chemotherapy rate, oncologist provision and hospitals offering oncology services were also reported. Geographical location was reported across nine studies. This was generally classified at US regional level based on Surveillance, Epidemiology and End Results (SEER) programme of cancer registries classification of geographical region. Statistically significant differences in treatment receipt were reported between different geographical regions both within and across studies. Studies reported geographical differences in treatment receipt, receipt of systemic and cancer therapies as part of EoL care and time to treatment. Statistically significant associations between geographical region and treatment receipt were reported for EOL care with lower likelihood for those residing in the West (OR 0.60 (0.50–0.71)) compared with the East as the reference category. Despite heterogeneity across studies, these findings may suggest regional variation in treatment receipt and time to treatment.
Population density was reported across seven studies. Classification was reported using urban/rural/metropolitan/nonmetropolitan classification. The greatest proportion of patients resided in urban areas > 80% with the only statistically significant finding reported for aggressive EOL care where rural hospital location was associated with a reduced likelihood of aggressive care (OR 0.75 (0.60–0.93)) [29]. Geographical location was associated with treatment receipt; however, this was not an explicit association with specific geographical regions, rather variation between regions, which suggested a degree of regional variation in treatment receipt and time to treatment, though lacked specificity.
Seven studies reported place of care [29, 31, 33, 37, 41, 42, 46]. Measures included rural/urban hospital location [29], minority-serving hospital/nonminority-serving hospital (MSH/non-MSH) defined as top decile of hospitals serving minority patients [24], public/private hospitals [41] teaching/research/community and cancer centre [42] and NCI/non-NCI designated centre [46]. Patients treated at MSH (where non-MSH was the reference group) were almost 40% less likely to receive palliative chemotherapy [37]. Similarly, patients treated at community hospitals and cancer centres had a lower likelihood of treatment receipt across all age groups compared with patients treated at teaching and research hospitals (OR 0.52 (0.38–0.72), 0.68 (0.54–0.86), 0.6 (0.50–0.73) and 0.76 (0.67–0.87)) respectively [42]. Women who received treatment at an academic centre had an increased likelihood of receipt of CDK4/6i compared with women who received treatment at a nonacademic centre (OR 2.18 1.32–3.59) [31].
For patients treated at an NCI versus non-NCI designated centre, there were statistically significant differences in baseline characteristics specifically for race where a greater proportion of White patients were treated at NCI centres 7% NCI compared with 14% non-NCI, P < 0.001 [46]. Patients treated at rural hospitals had a reduced likelihood of receipt of aggressive EOL care (OR 0.75 (0.60–0.93)) compared with urban locations [29], and for time to treatment, those treated at public hospitals had greater median time between diagnosis to treatment compared with those treated at private hospitals 76 days (64–86) compared with 60 days (52–65) [41]. Only the first three studies exclusively reported SBC patients; however, these consistent findings would suggest an association between place of care and treatment receipt [29, 41, 42].
Discussion
To our knowledge, our review was the first of its kind to identify and investigate geographic and sociodemographic factors associated with timely receipt of SACT for women with SBC. Receipt of SACT was found to be variable and ranged from 4% for immunotherapy treatment to 76% for the newer CDK4/6i to 78% for endocrine therapy and 80% for unspecified SACT (Shi, Sathe, Wang, Skinner). Twelve percent of women received no first-course therapy (Alves, small). In terms of timeliness of treatment, overall median time to treatment ranged from 54 to 96 days with differences attributed to health care system delays, treatment receipt at public or private hospital and race and ethnicity.
Anzeige
We found geographical differences for treatment receipt. These were reported between geographical regions though this was not an explicit association with specific geographical regions rather variation between regions. This suggested a degree of regional variation though lacked specificity. Importantly, place of care was found to be associated with treatment receipt. Patients treated at minority serving hospitals, community hospitals and cancer centres had a lower likelihood of treatment receipt. Our findings suggested an association between place of care and treatment receipt.
Our findings for geographical variation reflected those in the health geography literature for the relationship between access and receipt of care and treatment and geographical location. It has long been recognised that important variations in access to health care and health outcomes have been associated with geography. In particular, distance to health care has been identified as one of the most important geographic features that has affected health outcomes and the geographical distribution of health care facilities which has affected utilisation through differential opportunities for access to services.
Evidence of disparity and variation in relation to geography has previously been reported for early breast cancer for radiotherapy, surgical treatment and late stage diagnosis [49‐52]. A recent systematic review which examined differences in distance and travel time across multiple settings found evidence for an association between distance and poorer health outcomes which was preceded by a review of geographical variation in access to chemotherapy across multiple disease sites which found evidence for significant differences in chemotherapy utilisation related to cancer network geography with limited evidence for distance travelled [53, 54]. These reviews offered conflicting evidence for geographical disparity and neither explicitly reported on women with a secondary diagnosis. Further disparities within and between small area geographies have been reported though remained largely unexplained for women with a secondary diagnosis [10]. Our findings have provided new insights for women with a secondary diagnosis which require further exploration in terms of the complex interaction and potential effect modification between geographical location and health care systems factors.
Further factors associated with the timely receipt of SACT for women with SBC were found for sociodemographics for age, race, ethnicity and socioeconomic status. Older women, women of non-White race and women with a low SES were consistently reported to have a lower likelihood of timely treatment receipt. Clinical characteristics for comorbidities and clinical subtype of disease were associated with timely treatment receipt. Women with fewer comorbidities were more likely to receive treatment. A greater proportion of chemotherapy use was reported for women with hormone receptor-negative disease, and women with triple-negative disease were less likely to receive guideline concordant treatment.
Our findings were consistent with the wider breast cancer literature. Where it has been recognised, increasing age has been associated with a number of disparities. These have included lower screening rates, increased likelihood of advanced disease at diagnosis, reduced likelihood for treatment and opportunities for participation in clinical trials than younger women [55]. It has also been reported that older women are less likely to receive guideline concordant treatment, and the prevalence of ageist attitudes may impact the treatment that older women with breast cancer receive [56, 57]. Further systematic review evidence has suggested that older people are less likely to receive radical treatment disease [55].
Similarly for race and ethnicity, our review found that those of non-White origin were less likely to receive treatment in a less timely manner. This is consistent with the literature which has demonstrated previous disparities in relation to race and ethnicity [58]. This is both indirectly where race and ethnicity interact with other variables such as education, employment, housing and overall socioeconomic status and directly where these confounding variables have been subject to control and adjustment, through statistical analysis. This has been further reported in the literature for early breast cancer with the potentially confounding relationship between race and tumour and treatment heterogeneity [59].
Our findings provided new insights from the evidence for geographical disparities in the timely receipt of SACT for women with an SBC diagnosis which has previously remained unknown. We interpreted our findings within the context of a patient-centred framework for access [12]. This provided a useful interpretation of our review findings in terms of the impact of geographical location on dimensions of service accessibility related to availability and accommodation and the interface with women’s ability to seek and reach health care impacted by their sociodemographic and living environment. This offered a useful theoretical interpretation of our main findings.
Limitations
A number of limitations were acknowledged primarily related to the evidence included in the review. High levels of heterogeneity existed within and between studies in terms of factors reported which were associated with treatment receipt and time to treatment. Outcomes for time to treatment were not defined and measured consistently, and there were differences in the definition and measurement of outcomes for treatment receipt. This presented a particular challenge in the synthesis of these studies. Differences in reported outcomes and how these were measured at an individual study level also presented challenges in synthesis and precluded statistical meta-analysis.
There was significant variation in individual studies in terms of the number and proportion of women included with an advanced secondary breast cancer diagnosis. This presented challenges in terms of consistent data extraction despite the use of a uniform approach as part of the review methodology. This also presented challenges for the synthesis of studies in particular the weighting applied to the narrative. Study quality was assessed as low to moderate which may have had an impact on the overall findings from a methodological perspective. Furthermore, included studies were drawn from international populations which may have affected generalisability given the context-specific nature of geographic access to health care.
The published review protocol was developed and reported to conduct a mixed-method review. However, no qualitative studies were identified for inclusion. On this basis, it was also not possible to address the objective to explore women and clinicians experience of access and treatment receipt for secondary breast cancer. This also necessitated amendment to the published protocol for assessment of methodological quality and risk of bias and data analysis and synthesis.
Implications for practice, policy and future research
Our findings have a number of practical implications. Acknowledging the existence and understanding the complex nature of variation are fundamental to the development of appropriate strategies to address this in practice. Addressing unwarranted variation which has arisen from geographical disparity and place of care would require intervention at a strategic level from service commissioners and providers. This would need to consider the potential interaction and confounding relationship with wider social issues. A key consideration at all levels would be improvement in the availability and quality of routinely collected ‘real-world’ data to evidence the extent of variation. This could then be used in a more targeted way to support the development of initiatives aimed at reducing unwarranted variation. To address sociodemographic variation, a range of approaches may be required. These could include the development and piloting of targeted interventions to improve cultural competency for those groups most affected [60]. Clinical variation may require a range of strategies aimed at better engaging clinicians in the implementation of evidence-based treatment recommendations, guideline concordance and shared decision-making for preference sensitive care [61].
The review identified an overall lack of qualitative research into the experience of women and clinicians in terms of treatment access and receipt. This requires addressing with future research required in this area. Geographical variation requires further careful investigation which needs to address the interaction between geographical location and place of care. This is particularly important given recent policy initiatives for the greater centralisation of specialist cancer services and the recent parliamentary calls for a National Secondary Breast Cancer audit which will begin to identify and address some of the issues identified in the review [62].
The review also demonstrated a requirement for further epidemiological research using consistent, valid and reliable measures of exposure and outcome. This is required to provide a clear focus on the needs of women with a secondary diagnosis in relation to treatment receipt and will offer a more valid and reliable insight into specific issues for this group of women whose treatment needs have become increasingly complex. In particular, work to examine the role of clinical subtype of disease and treatment receipt as guideline concordance is guided by clinical subtype, and this is of particular importance in the era of personalised medicine.
Conclusion
Our review was the first of its kind to identify and investigate the broad range of factors associated with timely receipt of SACT for women with SBC. We identified variation associated with geographical location and place of care. This was identified as a potential interaction effect which adds to the existing literature in this area and requires further exploration in future research and at a strategic and policy level. Findings should however be interpreted with a degree of caution due to the limitations identified. Further research is required to address these limitations.
Acknowledgements
Mr. Daniel Livesey (updated searches), Libraries Manager, The Christie NHS Foundation Trust and Mr. Timothy Jacobs, Librarian, The Christie NHS Foundation Trust.
Declarations
Ethics approval and consent to participate
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Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
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