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Erschienen in: International Journal of Clinical Oncology 5/2011

01.10.2011 | Original Article

Ginsenoside Rg3 inhibits CXCR4 expression and related migrations in a breast cancer cell line

verfasst von: Xiao-ping Chen, Lin-lin Qian, Hong Jiang, Jiang-hua Chen

Erschienen in: International Journal of Clinical Oncology | Ausgabe 5/2011

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Abstract

Background

Ginsenoside Rg3 is an extract from the natural product ginseng. Previous studies have linked Rg3 with anti-metastasis of cancer in vivo and in vitro. CXC receptor 4 (CXCR4) is a vital molecule in migration and homing of cancer to the docking regions.

Methods

In this study, the effects of Rg3 on CXCR4 expression were investigated in a breast cancer cell line. Immunohistochemistry, chemotaxis and wound healing mobility assays were performed in cultured MDA-MB-231 cells.

Results

At a dosage without obvious cytotoxicity, Rg3 treatment elicits a weak CXCR4 stain color, decreases the number of migrated cells in CXCL12-elicited chemotaxis and reduces the width of the scar in wound healing.

Conclusion

This work suggests that Rg3 is a new CXCR4 inhibitor from a natural product.
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Metadaten
Titel
Ginsenoside Rg3 inhibits CXCR4 expression and related migrations in a breast cancer cell line
verfasst von
Xiao-ping Chen
Lin-lin Qian
Hong Jiang
Jiang-hua Chen
Publikationsdatum
01.10.2011
Verlag
Springer Japan
Erschienen in
International Journal of Clinical Oncology / Ausgabe 5/2011
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI
https://doi.org/10.1007/s10147-011-0222-6

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