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24.04.2020 | Original article

Glial fibrillary acidic protein (GFAP)-antibody in children with focal seizures of undetermined cause

verfasst von: Merve Savaş, John Tzartos, Cem İsmail Küçükali, Erdinç Dursun, Katerina Karagiorgou, Duygu Gezen-Ak, Dilşad Türkdoğan, Aliki Papaconstantinou, Sezin Başoğlu, Nilüfer Hacıhafızoğlu, Büşra Kutlubay, Socrates Tzartos, Erdem Tüzün

Erschienen in: Acta Neurologica Belgica | Ausgabe 5/2021

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Abstract

Anti-neuronal antibodies that are related with autoimmune encephalitis syndromes may also be found in children with new onset seizures or chronic epilepsy. To unravel the significance of autoimmune astrocytopathy in epilepsy, we investigated serum antibody to glial fibrillary acidic protein (GFAP), another autoantigen described in autoimmune encephalitis with seizures, in 38 children with focal seizures of undetermined cause. GFAP antibody was screened with cell based assay and indirect immunohistochemistry and was found in two boys with normal brain MRI and unrevealing medical history prior to seizures. The 2-year-old boy had chronic treatment-resistant frontal lobe epilepsy. The 2.5-year-old boy had a single episode of focal seizures and remained seizure free thereafter in a follow-up period of 4 years. Nevertheless, he showed severe cognitive and language impairment. These results suggest that autoimmune astrocytopathy may be present in some epilepsy patients. Whether this immune response is a bystander effect generated by seizure-induced astrocytosis or directly involved in epileptogenesis needs to be further studied.

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Titel: Glial fibrillary acidic protein (GFAP)-antibody in children with focal seizures of undetermined cause
verfasst von: Merve Savaş
John Tzartos
Cem İsmail Küçükali
Erdinç Dursun
Katerina Karagiorgou
Duygu Gezen-Ak
Dilşad Türkdoğan
Aliki Papaconstantinou
Sezin Başoğlu
Nilüfer Hacıhafızoğlu
Büşra Kutlubay
Socrates Tzartos
Erdem Tüzün
Publikationsdatum: 24.04.2020
Verlag: Springer International Publishing
Erschienen in: Acta Neurologica Belgica / Ausgabe 5/2021
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-020-01361-y

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